Details of Drug

Drug General Information (ID: D0296)
Drug Name	Ceftriaxone
Drug Type	Small molecule
Drug Synonymous	Biotrakson; CTRX; Cefatriaxone; Ceftriaxon; Ceftriaxona; Ceftriaxonum; Ceftriazone; Longacef; Longaceph; Rocefin; Rocephin; Rocephine; CEFTRIAXONE SODIUM; Ceftriaxone intravenous; Ro 139904; Ceftriaxona [INN-Spanish]; Ceftriaxone (INN); Ceftriaxone (TN); Ceftriaxone [USAN:JAN]; Ceftriaxone, Disodium Salt; Ceftriaxonum [INN-Latin]; DRG-0071; Ro13-9904; Rocephin (TN); Ceftriaxone, Disodium Salt, Hemiheptahydrate; Ro-13-9904; (6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-(O-methyloxime), sesquaterhydrate; (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C18H18N8O7S3
InChI	1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1
InChIKey	VAAUVRVFOQPIGI-SPQHTLEESA-N
Canonical SMILES	CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O
External Link
	Pubchem ID	5479530
	CAS Number	73384-59-5
	CHEBI ID	29007
	TTD ID	D07ACT
	INTEDE ID	DR2655
	VARIDT ID	DR00553

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM031 Increased renal excretion (Unspecific) BM050 Increased risk of bleeding BM072 Increased risk of nephrotoxicity BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Ceftriaxone
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[72], [73]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[72], [73]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[74]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[77]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[61]
Affected excretion pathways
	Increased renal excretion (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[53], [54], [57]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[53], [54], [57]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[50], [51], [52]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[50], [51], [52]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[50], [51], [52]
D0753		Heparin	C26H42N2O37S5	772	Minor		Inter Info	[75], [76]
	Increased risk of nephrotoxicity					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[20], [28], [49]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[71]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0237		Calcium chloride	CaCl2H4O2	24844	Major		Inter Info	[1], [2], [3]
D0240		Calcium glucoheptonate	C14H26CaO16	62859	Major		Inter Info	[1], [2], [3]
D0241		Calcium gluconate	C12H22CaO14	9290	Major		Inter Info	[1], [2], [3]
D0549		Edetate calcium disodium anhydrous	C10H12CaN2Na2O8	6093170	Major		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[7], [8], [9]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[10]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1832		Levoleucovorin	C20H23N7O7	135398559	Major		Inter Info	[1], [4], [5]
D1864		Pentetic acid	C14H23N3O10	3053	Major		Inter Info	[1], [6], [2]
D1830		Leucovorin	C20H23N7O7	135403648	Major		Inter Info	[1], [6], [2]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[62], [63], [64]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[65], [66], [67]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[68], [69], [70]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[62], [63], [64]

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