Details of Drug

Drug General Information (ID: D0245)
Drug Name	Canagliflozin
Drug Type	Small molecule
Drug Synonymous	842133-18-0; Invokana; Canagliflozin anhydrous; canagliflozin hemihydrate; UNII-6S49DGR869; JNJ-28431754; JNJ 24831754ZAE; Canagliflozin hydrate; TA-7284; 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene; CHEBI:73274; 6S49DGR869; (2S,3R,4R,5S,6R)-2-(3-((5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHYL)-4-METHYLPHENYL)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; TA 7284; (1S)-1,5-anhydro-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol; 928672-86-0 Click to Show/Hide
Disease Class	5A11: Type 2 diabetes mellitus; GB61: Chronic kidney disease; 5A10: Diabetes mellitus
Therapeutic Class	Antidiabetic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C24H25FO5S
InChI	1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1
InChIKey	XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
Canonical SMILES	CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F
External Link
	Pubchem ID	24812758
	CAS Number	842133-18-0
	CHEBI ID	73274
	TTD ID	D08DFX
	INTEDE ID	DR0262
	VARIDT ID	DR00279

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM023 UGT induction BM042 Additive hypotensive effects BM064 Increased risk of hypoglycemia BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Canagliflozin
Affected cellular transport
	Transporter inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[4], [25]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[4], [5], [10]
Affected intra/extra-hepatic metabolism
	UGT induction					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[4], [5], [10]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[4], [5], [10]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[4], [5], [10]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [5], [10]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[4], [5], [10]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [5], [10]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[4], [5], [10]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[4], [5], [10]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [5], [10]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[4], [5], [10]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[4], [5], [10]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[4], [5], [10]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[4], [5], [10]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 112
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[4], [5], [6]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[4], [5], [6]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[4], [5], [6]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[4], [5], [6]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[4], [5], [6]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[4], [5], [6]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[4], [5], [6]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[4], [5], [6]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[4], [5], [6]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[4], [5], [6]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[4], [5], [6]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[12], [10], [11]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[12], [10], [11]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4], [5], [6]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[4], [5], [6]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[4], [5], [6]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[4], [5], [6]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[5], [10], [6]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[4], [5], [6]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[4], [5], [6]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[4], [5], [6]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[4], [5], [6]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[4], [5], [6]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[4], [5], [6]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[4], [5], [6]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[4], [5], [6]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[4], [5], [6]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[12], [10], [11]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[12], [10], [11]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[4], [5], [6]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[4], [5], [6]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[4], [5], [6]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[4], [5], [6]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[4], [5], [6]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[4], [5], [6]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[4], [5], [6]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[4], [5], [6]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[4], [5], [6]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[4], [5], [6]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[4], [5], [6]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[5], [10], [6]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4], [5], [6]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[4], [5], [6]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[4], [5], [6]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[5], [10], [6]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[4], [5], [6]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[4], [5], [6]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[4], [5], [6]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[4], [5], [6]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[12], [10], [11]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[12], [10], [11]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[4], [5], [6]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[12], [10], [11]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[4], [5], [6]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[4], [5], [6]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[4], [5], [6]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4], [5], [6]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[4], [5], [6]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[4], [5], [6]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[4], [5], [6]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[4], [5], [6]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[4], [5], [6]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[4], [5], [6]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[4], [5], [6]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[12], [10], [11]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[4], [5], [6]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[4], [5], [6]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[4], [5], [6]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[4], [5], [6]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[4], [5], [6]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[4], [5], [6]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[4], [5], [6]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[4], [5], [6]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [5], [6]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[4], [5], [6]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[4], [5], [6]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[4], [5], [6]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[4], [5], [6]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[4], [5], [6]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[4], [5], [6]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[4], [5], [6]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[4], [5], [6]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[4], [5], [6]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[4], [5], [6]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[4], [5], [6]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[12], [10], [11]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[4], [5], [6]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [5], [6]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[4], [5], [6]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[4], [5], [6]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[4], [5], [6]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[4], [5], [6]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[4], [5], [6]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[4], [5], [6]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[4], [5], [6]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[4], [5], [6]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[4], [5], [6]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[4], [5], [6]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[4], [5], [6]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[4], [5], [6]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[4], [5], [6]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[4], [5], [6]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[5], [10], [6]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[4], [5], [6]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[4], [5], [6]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[4], [5], [6]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[12], [10], [11]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[4], [5], [6]
D1668		Urea	CH4N2O	1176	Moderate		Inter Info	[4], [5], [6]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[4], [5], [6]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[4], [5], [6]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [5], [6]
	Increased risk of hypoglycemia					Drug Num: 51
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[10], [6], [11]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[13], [14], [15]
D1736		Aloe Vera Leaf	C15H10O5	10207	Moderate		Inter Info	[16], [17], [18]
D1759		Chromic chloride	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[22], [23], [24]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[10], [6], [11]
D1661		Turmeric	C21H20O6	969516	Moderate		Inter Info	[26], [27], [28]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[22], [23], [24]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[22], [23], [24]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[13], [14], [15]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[13], [14], [15]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[22], [23], [24]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[13], [14], [15]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[22], [23], [24]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[29], [30], [31]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[10], [6], [11]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[10], [6], [11]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[10], [6], [11]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[22], [23], [24]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[10], [6], [11]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[10], [6], [11]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[10], [6], [11]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[10], [6], [11]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [6], [11]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [6], [11]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [6], [11]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [6], [11]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [6], [11]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [6], [11]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[10], [6], [11]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[10], [6], [11]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[22], [23], [24]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[22], [23], [24]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[13], [14], [15]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[13], [14], [15]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[13], [14], [15]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[22], [23], [24]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[22], [23], [24]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[10], [6], [11]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[22], [23], [24]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[22], [23], [24]
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[13], [14], [15]
D1862		Pegvisomant	NA	NA	Moderate		Inter Info	[35], [36], [37]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[13], [14], [15]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[13], [14], [15]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[10], [6], [11]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[13], [14], [15]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[22], [23], [24]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[10], [6], [11]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[10], [6], [11]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[22], [23], [24]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 132
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[1], [2], [3]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[7], [8], [9]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[7], [8], [9]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[7], [8], [9]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[7], [8], [9]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[7], [8], [9]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[7], [8], [9]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[7], [8], [9]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[7], [8], [9]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[7], [8], [9]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[7], [8], [9]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[7], [8], [9]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[7], [8], [9]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[7], [8], [9]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[7], [8], [9]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[7], [8], [9]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[7], [8], [9]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[7], [8], [9]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[7], [8], [9]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[7], [8], [9]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[7], [8], [9]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[7], [8], [9]
D1531		Tagraxofusp	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[7], [8], [9]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[7], [8], [9]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[7], [8], [9]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[7], [8], [9]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[7], [8], [9]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[7], [8], [9]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[7], [8], [9]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[7], [8], [9]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[7], [8], [9]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[7], [8], [9]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[7], [8], [9]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[7], [8], [9]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[7], [8], [9]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[7], [8], [9]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[7], [8], [9]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[7], [8], [9]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[7], [8], [9]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[7], [8], [9]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[7], [8], [9]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[7], [8], [9]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[7], [8], [9]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[7], [8], [9]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[7], [8], [9]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[7], [8], [9]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[7], [8], [9]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[7], [8], [9]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[7], [8], [9]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[7], [8], [9]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[7], [8], [9]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[7], [8], [9]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[7], [8], [9]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[7], [8], [9]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[7], [8], [9]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[7], [8], [9]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[7], [8], [9]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[7], [8], [9]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[7], [8], [9]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[7], [8], [9]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[32], [33], [34]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[7], [8], [9]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[7], [8], [9]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[7], [8], [9]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[7], [8], [9]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[7], [8], [9]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[7], [8], [9]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[7], [8], [9]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[7], [8], [9]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[7], [8], [9]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[7], [8], [9]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[7], [8], [9]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[7], [8], [9]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[7], [8], [9]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[7], [8], [9]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[7], [8], [9]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[7], [8], [9]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[7], [8], [9]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[7], [8], [9]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[7], [8], [9]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[7], [8], [9]
D1132		Nicotinamide	C6H6N2O	936	Moderate		Inter Info	[7], [8], [9]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[7], [8], [9]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[7], [8], [9]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[32], [33], [34]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[7], [8], [9]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[7], [8], [9]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[7], [8], [9]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[7], [8], [9]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[32], [33], [34]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[7], [8], [9]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[7], [8], [9]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[7], [8], [9]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[7], [8], [9]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[7], [8], [9]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[7], [8], [9]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[7], [8], [9]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[7], [8], [9]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[7], [8], [9]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[7], [8], [9]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[7], [8], [9]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[7], [8], [9]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[7], [8], [9]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[7], [8], [9]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[7], [8], [9]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[7], [8], [9]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[7], [8], [9]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[7], [8], [9]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[7], [8], [9]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[7], [8], [9]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[7], [8], [9]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[7], [8], [9]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[7], [8], [9]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[7], [8], [9]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[7], [8], [9]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[7], [8], [9]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[7], [8], [9]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[7], [8], [9]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[7], [8], [9]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[7], [8], [9]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[7], [8], [9]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[7], [8], [9]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[7], [8], [9]
D1707		Vorinostat	C14H20N2O3	5311	Moderate		Inter Info	[7], [8], [9]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[7], [8], [9]
D1762		Clobetasol (topical)	C22H28ClFO4	5311051	Minor		Inter Info	[38], [39], [40]
D0685		Fluticasone (topical)	C22H27F3O4S	5311101	Minor		Inter Info	[38], [39], [40]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Minor		Inter Info	[5], [35], [36]
	Antagonize the effect of antihypertensive agents					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1888		Sermorelin	C149H246N44O42S	16132413	Moderate		Inter Info	[7], [8], [9]
D1900		Teprotumumab	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1902		Tesamorelin	C221H366N72O67S	16137828	Moderate		Inter Info	[7], [8], [9]
D1908		Thyrotropin alfa	C16H22N6O4	32281	Moderate		Inter Info	[7], [8], [9]
D1735		Alclometasone (topical)	C22H29ClO5	5311000	Minor		Inter Info	[38], [39], [40]
D1737		Amcinonide	C28H35FO7	443958	Minor		Inter Info	[38], [39], [40]
D1748		Betamethasone (topical)	C22H29FO5	9782	Minor		Inter Info	[38], [39], [40]
D1763		Clocortolone (topical)	C22H28ClFO4	5311052	Minor		Inter Info	[38], [39], [40]
D1770		Desonide (topical)	C24H32O6	5311066	Minor		Inter Info	[38], [39], [40]
D1771		Desoximetasone (topical)	C22H29FO4	5311067	Minor		Inter Info	[38], [39], [40]
D1772		Dexamethasone (topical)	C22H29FO5	5743	Minor		Inter Info	[38], [39], [40]
D1773		Diflorasone (topical)	C22H28F2O5	71415	Minor		Inter Info	[38], [39], [40]
D1786		Fluocinonide (topical)	C26H32F2O7	9642	Minor		Inter Info	[38], [39], [40]
D1788		Flurandrenolide (topical)	C24H33FO6	15209	Minor		Inter Info	[38], [39], [40]
D1804		Halcinonide (topical)	C24H32ClFO5	443943	Minor		Inter Info	[38], [39], [40]
D1813		Hydrocortisone (topical)	C21H30O5	5754	Minor		Inter Info	[38], [39], [40]
D1844		Methylprednisolone (topical)	C22H30O5	6741	Minor		Inter Info	[38], [39], [40]
D1869		Prednicarbate (topical)	C27H36O8	6714002	Minor		Inter Info	[38], [39], [40]
D1911		Triamcinolone (topical)	C21H27FO6	31307	Minor		Inter Info	[38], [39], [40]
D1916		Ulobetasol (topical)	C22H27ClF2O4	5311167	Minor		Inter Info	[38], [39], [40]

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