Details of Drug

Drug General Information (ID: D0228)
Drug Name	Cabergoline
Drug Type	Small molecule
Drug Synonymous	Cabaser; Cabaseril; Cabergolina; Cabergolinum; Dostinex; Galastop; Sogilen; Cabergolina [Spanish]; Cabergolinum [Latin]; CG-101; Cabaser (TN); Dostinex (TN); FCE-21336; Cabergoline [USAN:BAN:INN]; Cabergoline (JAN/USAN/INN); (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide; (8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide; (8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide; (8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-prop-2-en-1-ylergoline-8-carboxamide; 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea; 1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea; 1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate; 1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea Click to Show/Hide
Disease Class	5A60-5A61: Pituitary gland disorder
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C26H37N5O2
InChI	1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
InChIKey	KORNTPPJEAJQIU-KJXAQDMKSA-N
Canonical SMILES	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
External Link
	Pubchem ID	54746
	CAS Number	81409-90-7
	CHEBI ID	3286
	TTD ID	D04EGX
	INTEDE ID	DR0253
	VARIDT ID	DR00069

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM040 Additive dopaminergic effects BM042 Additive hypotensive effects BM046 Additive serotonergic effects BM093 Antagonize the effect of dopaminergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Cabergoline
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1825		Ioflupane I-123	C18H23FINO2	3086674	Moderate		Inter Info	[51], [26], [52]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7], [8], [5], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7], [8], [5], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[7], [8], [5], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[7], [8], [5], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [21]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[5], [57]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[22], [23], [24]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[28], [29]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[48]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[4], [49]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[50]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[53], [54], [55]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[56]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[59]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
	Additive dopaminergic effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[58]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[5], [60]
	Additive hypotensive effects					Drug Num: 77
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[30], [31], [32]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[30], [31], [32]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[30], [31], [32]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[30], [31], [32]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[30], [31], [32]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[30], [31], [32]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[30], [31], [32]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[30], [31], [32]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[30], [31], [32]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[30], [31], [32]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[30], [31], [32]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[30], [31], [32]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[30], [31], [32]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[30], [31], [32]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[30], [31], [32]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[30], [31], [32]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[30], [31], [32]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[30], [31], [32]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[30], [31], [32]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[30], [31], [32]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[30], [31], [32]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[30], [31], [32]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[30], [31], [32]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[30], [31], [32]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[30], [31], [32]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[30], [31], [32]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[30], [31], [32]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[30], [31], [32]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[30], [31], [32]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[30], [31], [32]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[30], [31], [32]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[30], [31], [32]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[30], [31], [32]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[30], [31], [32]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[30], [31], [32]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[30], [31], [32]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[30], [31], [32]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[30], [31], [32]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[30], [31], [32]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[30], [31], [32]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[30], [31], [32]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[30], [31], [32]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[30], [31], [32]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[30], [31], [32]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[30], [31], [32]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[30], [31], [32]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[30], [31], [32]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[30], [31], [32]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[30], [31], [32]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[30], [31], [32]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[30], [31], [32]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[30], [31], [32]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[30], [31], [32]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[30], [31], [32]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[30], [31], [32]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[30], [31], [32]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[30], [31], [32]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[30], [31], [32]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[30], [31], [32]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[30], [31], [32]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[30], [31], [32]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[30], [31], [32]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[30], [31], [32]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[30], [31], [32]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[30], [31], [32]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[30], [31], [32]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[30], [31], [32]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[30], [31], [32]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[30], [31], [32]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[30], [31], [32]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[30], [31], [32]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[30], [31], [32]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[30], [31], [32]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[30], [31], [32]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[30], [31], [32]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[30], [31], [32]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[30], [31], [32]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[1], [2], [3]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[1], [2], [3]
D0952		Lorcaserin	C11H14ClN	11658860	Major		Inter Info	[25], [26], [27]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[1], [2], [3]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[1], [2], [3]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[1], [2], [3]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[1], [2], [3]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Antagonize the effect of dopaminergic agents					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[4], [5], [6]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[33], [34], [35]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [43], [44], [45], [46], [35], [47]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[36], [37], [38], [39], [33], [2], [40], [41], [34], [42], [43], [44], [45], [46], [35], [47]

References
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