Details of Drug

Drug General Information (ID: D0215)
Drug Name	Budesonide
Drug Type	Small molecule
Drug Synonymous	Bidien; Budenofalk; Budeson; Budesonido; Budesonidum; Budiair; Cortivent; Entocort; Horacort; Inflammide; Micronyl; Miflonide; Preferid; Pulmaxan; Respules; Rhinocort; Spirocort; UDB; Budecort Inhaler; Budesonide Easyhaler; Budesonide MMX; Entocort EC; GionaEasyhaler; Pulmaxan turbohaler; Pulmicort Flexhaler; Pulmicort Nebuamp; Pulmicort Respules; Pulmicort Topinasal; Pulmicort turbuhaler; Rhinocort Aqua; Rhinocort Turbuhaler; Rhinocort alpha; Unit dosebudesonide; B 7777; S 1320; Budesonido [INN-Spanish]; Budesonidum [INN-Latin]; Entocort (TN); Entocort EC (TN); MAP-0010; Noex (TN); Pulmicort (TN); Rhinocort (TN); S-1320; Budesonide (JAN/USAN/INN); Budesonide [USAN:INN:BAN:JAN]; Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide; Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-,and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione; (11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione; (11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione; (4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; (R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde; (RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione; (RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde; (S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione; 11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione; 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione; 16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione; 16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione; 16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione; 16alpha-,17alpha-butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione Click to Show/Hide
Disease Class	CA23: Asthma
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C25H34O6
InChI	1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
InChIKey	VOVIALXJUBGFJZ-KWVAZRHASA-N
Canonical SMILES	CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C
External Link
	Pubchem ID	5281004
	CAS Number	51333-22-3
	CHEBI ID	3207
	TTD ID	D0Y7IU
	INTEDE ID	DR0239
	VARIDT ID	DR00323

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM009 Altered absorption (Unspecific) BM014 Interference of cell/tissue uptake BM015 Increase globulin concentration BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM026 Increased metabolism (Unspecific) BM043 Additive immunosuppressive effects BM054 Increased risk of GI mucosal injury/bleeding risk BM056 Increased risk of hyperammonemia BM057 Increased risk of hyperglycemia BM065 Increased risk of hypokalemia BM067 Increased risk of hyponatremia BM080 Increased risk of tendinitis/tendon rupture BM083 Potentiated the pharmacological effects (Unspecific) BM089 Antagonize the effect of antihypertensive agents BM091 Antagonize the effect of cholinergic agents BM092 Antagonize the effect of corticosteroids BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific) BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Budesonide
Affected gastrointestinal absorption
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[99], [100], [101], [102], [103]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[99], [100], [101], [102], [103]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[99], [100], [101], [102], [103]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[142], [143], [144]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0708		Gallium chloride Ga-67	Cl3Ga	73415785	Moderate		Inter Info	[112]
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[115]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[116], [47], [117]
	Increase globulin concentration					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[108], [109], [110]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[108], [109], [110]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[108], [109], [110]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[108], [109], [110]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[108], [109], [110]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[108], [109], [110]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[108], [109], [110]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[108], [109], [110]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[108], [109], [110]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[108], [109], [110]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[108], [109], [110]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[108], [109], [110]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[108], [109], [110]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[108], [109], [110]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 71
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[76]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[7], [8], [9]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[7], [8], [9]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[111]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[118]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[7], [8], [9]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[123]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[8], [9], [152], [153]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[138], [139]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[138], [139]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[138], [139]
	Increased metabolism (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[133], [134], [135]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[133], [134], [135]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[133], [134], [135]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[23], [24], [25]
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[9]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[9]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[28]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [29]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[8], [30]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[35], [36]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[23], [24], [25]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[37]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[9], [38]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[35], [36]
D1111		Natalizumab	NA	NA	Major		Inter Info	[45]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[31], [54], [55]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[56]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[60], [61], [62]
D0118		Atezolizumab	NA	NA	Moderate		Inter Info	[82], [83], [84], [8], [85], [9], [86], [87], [88], [89]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[60], [61], [62]
D0299		Cemiplimab	NA	NA	Moderate		Inter Info	[82], [83], [84], [8], [85], [9], [86], [87], [88], [89]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[106]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[107]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[107]
D0541		Durvalumab	NA	NA	Moderate		Inter Info	[82], [83], [84], [8], [85], [9], [86], [87], [88], [89]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[82], [83], [84], [8], [85], [9], [86], [87], [88], [89]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[107]
D1150		Nivolumab	NA	NA	Moderate		Inter Info	[82], [83], [84], [8], [85], [9], [86], [87], [88], [89]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[121]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[122]
D1240		Pembrolizumab	NA	NA	Moderate		Inter Info	[82], [83], [84], [8], [85], [9], [86], [87], [88], [89]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[60], [61], [62]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[9], [131]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[140]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[141]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[149], [150], [151]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[50], [51], [52]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[104], [105], [50], [51], [52]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[50], [51], [52]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[9]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[104], [105], [50], [51], [52]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[70], [73], [75]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[50], [51], [52]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[66], [67], [68], [69], [70], [52], [71], [72], [73], [74], [75]
	Increased risk of hyperammonemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[8], [113], [114]
D1275		Phenylbutyric acid	C10H12O2	4775	Moderate		Inter Info	[8], [113], [114]
	Increased risk of hyperglycemia					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[63], [64], [65]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[63], [64], [65]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[63], [64], [65]
	Increased risk of hypokalemia					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[77], [78], [79]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[77], [78], [79]
D0103		Arformoterol	C19H24N2O4	3083544	Minor		Inter Info	[82], [8], [9], [154]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[82], [8], [9], [154]
D0924		Levosalbutamol	C13H21NO3	123600	Minor		Inter Info	[8], [9], [154]
D1298		Pirbuterol	C12H20N2O3	4845	Minor		Inter Info	[82], [8], [9], [154]
D1374		Racepinephrine	C9H13NO3	838	Minor		Inter Info	[82], [8], [9], [154]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Minor		Inter Info	[8], [9], [154]
D0691		Formoterol	C19H24N2O4	3410	Minor		Inter Info	[82], [8], [9], [154]
D0854		Isoetharine	C13H21NO3	3762	Minor		Inter Info	[82], [8], [9], [154]
D0859		Isoprenaline	C11H17NO3	3779	Minor		Inter Info	[8], [9], [154]
D1185		Orciprenaline	C11H17NO3	4086	Minor		Inter Info	[8], [9], [154]
D1414		Ritodrine	C17H21NO3	33572	Minor		Inter Info	[82], [8], [9], [154]
D1438		Salbutamol	C13H21NO3	2083	Minor		Inter Info	[8], [9], [154]
D1440		Salmeterol	C25H37NO4	5152	Minor		Inter Info	[82], [8], [9], [154]
D1554		Terbutaline	C12H19NO3	5403	Minor		Inter Info	[82], [8], [9], [154]
	Increased risk of hyponatremia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Major		Inter Info	[39], [9], [40], [41], [42], [8]
	Increased risk of tendinitis/tendon rupture					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0155		Bempedoic acid	C19H36O5	10472693	Major		Inter Info	[26], [27]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1042		Methyltestosterone	C20H30O2	6010	Moderate		Inter Info	[119], [120]
D1207		Oxymetholone	C21H32O3	5281034	Moderate		Inter Info	[119], [120]
D1503		Stanozolol	C21H32N2O	25249	Moderate		Inter Info	[119], [120]
D0677		Fluoxymesterone	C20H29FO3	6446	Moderate		Inter Info	[119], [120]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[119], [120]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[119], [120]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[119], [120]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1694		Vigabatrin	C6H11NO2	5665	Major		Inter Info	[46], [47], [48]
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[132]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[136], [137]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[145], [146], [147]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[136], [137]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 58
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[9], [49]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[9], [49]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[9], [49]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[9], [49]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[9], [49]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[9], [49]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[9], [49]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[9], [49]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[9], [49]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[9], [49]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[9], [49]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[9], [49]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[9], [49]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[9], [49]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[9], [49]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[9], [49]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[9], [49]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[9], [49]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[9], [49]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[9], [49]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[9], [49]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[9], [49]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[9], [49]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[9], [49]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[9], [49]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[9], [49]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[9], [49]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[9], [49]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[9], [49]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[9], [49]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[9], [49]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[9], [49]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[9], [49]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[9], [49]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[9], [49]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[9], [49]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[9], [49]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[9], [49]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[9], [49]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[9], [49]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[9], [49]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[9], [49]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[9], [49]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[9], [49]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[9], [49]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[9], [49]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[9], [49]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[9], [49]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[9], [49]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[9], [49]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[9], [49]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[9], [49]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[9], [49]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[9], [49]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[9], [49]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[9], [49]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[9], [49]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[9], [49]
	Antagonize the effect of cholinergic agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[57], [58], [59]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[57], [58], [59]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[57], [58], [59]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[57], [58], [59]
	Antagonize the effect of corticosteroids					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[43], [44]
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[31], [32], [33]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[34]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[31], [80], [81]
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Moderate		Inter Info	[90], [91], [92]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [80], [81]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[31], [80], [81]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[31], [80], [81]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[31], [80], [81]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[31], [80], [81]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [80], [81]
D1839		Measles virus vaccine live attenuated	NA	NA	Moderate		Inter Info	[90], [91], [92]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[31], [80], [81]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Moderate		Inter Info	[90], [91], [92]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[124], [31], [8], [125], [126], [127], [80], [128], [129], [130], [81]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [80], [81]
D1881		Rotavirus vaccine	NA	NA	Moderate		Inter Info	[90], [91], [92]
D1882		Rubella virus vaccine	NA	NA	Moderate		Inter Info	[90], [91], [92]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[31], [80], [81]
D1914		Typhoid vaccine (live)	NA	NA	Moderate		Inter Info	[90], [91], [92]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[90], [91], [92]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[31], [80], [81]
D1922		Yellow Fever Vaccine	NA	NA	Moderate		Inter Info	[90], [91], [92]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[148]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[93], [94], [95]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[93], [94], [95]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[96], [97], [98]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[96], [97], [98]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[96], [97], [98]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[96], [97], [98]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[53]
D1812		Hyaluronidase	C17H24BrNO2	91820602	Minor		Inter Info	[158], [159], [160]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[155], [156], [157]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[155], [156], [157]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[155], [156], [157]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[155], [156], [157]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[155], [156], [157]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[155], [156], [157]

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Enbrel (etanercept). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Product Information. Humira (adalimumab). Abbott Pharmaceutical, Abbott Park, IL.
4	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
5	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
6	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
7	Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN "Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole." Ann Pharmacother 38 (2004): 46-9. [PMID: 14742792]
8	Cerner Multum, Inc. "Australian Product Information.".
9	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
10	Daveluy A, Raignoux C, Miremont-Salame G, et al. "Drug interactions between inhaled corticosteroids and enzymatic inhibitors." Eur J Clin Pharmacol (2009):. [PMID: 19399485]
11	De Wachter E, Malfroot A, De Schutter I, Vanbesien J, De Schepper J "Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450." J Calif Dent Assoc 2 (2003): 72-5. [PMID: 15463853]
12	De Wachter E, Vanbesien J, De Schutter I, Malfroot A, De Schepper J "Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide." Eur J Pediatr (2003):. [PMID: 12719971]
13	Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
14	Jonsson G, Astrom A, Andersson P "Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver." Drug Metab Dispos 23 (1995): 137-42. [PMID: 7720517]
15	Kedem E, Shahar E, Hassoun G, Pollack S "Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient." J Asthma 47 (2010): 830-1. [PMID: 20653496]
16	Main KM, Skov M, Sillesen IB, et al. "Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient." Acta Paediatr 91 (2002): 1008-11. [PMID: 12412882]
17	Molimard M, Girodet PO, Pollet C, et al. "Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation." Drug Saf 31 (2008): 769-74. [PMID: 18707191]
18	Product Information. Entocort (budesonide). AstraZeneca Pharma Inc, Mississauga, ON.
19	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
20	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
21	Raaska K, Niemi M, Neuvonen M, Neuvonen PJ, Kivisto KT "Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole." Clin Pharmacol Ther 72 (2002): 362-369. [PMID: 12386638]
22	Skov M, Main KM, Sillesen IB, Muller J, Koch C, Lanng S "Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide." Eur Respir J 20 (2002): 127-33. [PMID: 12166560]
23	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
24	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
25	Strate LL, Liu YL, Huang ES, Giovannucci EL, Chan AT "Use of Aspirin or Nonsteroidal Anti-inflammatory Drugs Increases Risk for Diverticulitis and Diverticular Bleeding." Gastroenterology 140 (2011): 1427-33.[PMID: 21320500]
26	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
27	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
28	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
29	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
30	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
31	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
32	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
33	CDC. Centers for Disease Control and Prevention "Clinical guidance for smallpox vaccine use in a postevent vaccination program.".
34	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
35	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
36	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
37	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
38	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
39	Product Information. Stimate (desmopressin). Forest Pharmaceuticals, St. Louis, MO.
40	Product Information. Nocdurna (desmopressin). Ferring Inc, North York, ON.
41	Product Information. Noctiva (desmopressin). Avadel Pharmaceuticals, Chesterfield, MO.
42	Product Information. DDAVP (desmopressin). Rhone-Poulenc Rorer, Collegeville, PA.
43	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
44	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
45	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
46	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
47	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
48	Product Information. Sabril (vigabatrin). Lundbeck Inc, Deerfield, IL.
49	Multum Information Services, Inc. Expert Review Panel.
50	Hansen RA, Tu W, Wang J, Ambuehl R, McDonald CJ, Murray MD "Risk of adverse gastrointestinal events from inhaled corticosteroids." Pharmacotherapy 28 (2008): 1325-34. [PMID: 18956992]
51	Koren G, Roifman C, Gelfand E, Lavi S, Suria D, Stein L "Corticosteroids-salicylate interaction in a case of juvenile rheumatoid arthritis." Ther Drug Monit 9 (1987): 177-9. [PMID: 3617157]
52	Piper JM, Ray WA, Daugherty JR, Griffin MR "Corticosteroid use and peptic ulcer disease: role of nonsteroidal ani-inflammatory drugs." Ann Intern Med 114 (1991): 735-40. [PMID: 2012355]
53	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
54	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
55	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
56	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
57	Brunner NG, Namba T, Grob D "Corticosteroids in management of severe, generalized myasthenia gravis." Neurology 22 (1972): 603-10
58	Namba T "Corticotropin therapy in patients with myasthenia gravis." Arch Neurol 26 (1972): 144-50
59	Patten BM, Oliver KL, Engel WK "Adverse interaction between steroid hormones and anticholinesterase drugs." Neurology 24 (1974): 442-9
60	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
61	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
62	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
63	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
64	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
65	Kawedia JD, Liu C, Pei D, Cheng C, Fernandez CA, Howard SC, Campana D, Panetta JC, Bowman WP, Evans WE, Pui CH, Relling MV. Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia. Blood. 2012 Feb 16;119(7):1658-64.
66	Buchman AL, Schwartz MR "Colonic ulceration associated with the systemic use of nonsteroidal antiinflammatory medication." J Clin Gastroenterol 22 (1996): 224-6. [PMID: 8724264]
67	Cantu TG, Lipani JA "Gastrointestinal ulceration with NSAIDs." Am J Med 99 (1995): 440-1. [PMID: 7573106]
68	Kaufman DW, Kelly JP, Sheehan JE, Laszlo A, Wiholm BE, Alfredsson L, Koff RS, Shapiro S "Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding." Clin Pharmacol Ther 53 (1993): 485-94. [PMID: 8477566]
69	Levy M, Miller DR, Kaufman DW, Siskind V, Schwingl P, Rosenberg L, Strom B, Shapiro S "Major upper gastrointestinal tract bleeding. Relation to the use of aspirin and other nonnarcotic analgesics." Arch Intern Med 148 (1988): 281-5. [PMID: 3257680]
70	Messer J, Reitman D, Sacks HS, et al "Association of adrenocorticosteroid therapy and peptic-ulcer disease." N Engl J Med 309 (1983): 21-4. [PMID: 6343871]
71	ReMine SG, McIlrath DC "Bowel perforation in steroid-treated patients." Ann Surg 192 (1980): 581-6. [PMID: 7425698]
72	Sacanella E, Munoz F, Cardellach F, Estruch R, Miro O, Urbanomarquez A "Massive haemorrhage due to colitis secondary to nonsteroidal anti-inflammatory drugs." Postgrad Med J 72 (1996): 57-8. [PMID: 8746289]
73	Stewart JT, Pennington CR, Pringle R "Anti-inflammatory drugs and bowel perforations and haemorrhage." Br Med J 290 (1985): 787-8. [PMID: 3918755]
74	Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5. [PMID: 6698408]
75	Wilcox CM, Shalek KA, Cotsonis G "Striking prevalence of over-the-counter nonsteroidal anti- inflammatory drug use in patients with upper gastrointestinal hemorrhage." Arch Intern Med 154 (1994): 42-6. [PMID: 8267488]
76	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
77	Leavengood DC, Bunker-Soler AL, Nelson HS "The effect of corticosteroids on theophylline metabolism." Ann Allergy 50 (1983): 249-51
78	Fergusson RJ, Scott CM, Rafferty P, Gaddie J "Effect of prednisolone on theophylline pharmacokinetics in patients with chronic airflow obstruction." Thorax 42 (1987): 195-8
79	Buchanan N, Hurwitz S, Butler P "Asthma - a possible interaction between hydrocortisone and theophylline." S Afr Med J 56 (1979): 1147-8
80	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
81	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
82	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
83	Arbour KC, Mezquita L, Long N, et al. "Impact of Baseline Steroids on Efficacy of Programmed Cell Death-1 and Programmed Death-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer." J Clin Oncol 36 (2018): 2872-2878. [PMID: 30125216]
84	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
85	Cerner Multum, Inc. "Canadian Product Information.".
86	Jove M, Vilarino N, Nadal E "Impact of baseline steroids on efficacy of programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) blockade in patients with advanced non-small cell lung cancer." Transl Lung Cancer Res 8 (2019): S364-8. [PMID: 32038916]
87	Scott SC, Pennell NA "Early use of systemic corticosteroids in patients with advanced NSCLC treated with nivolumab." J Thorac Oncol 13 (2018): 1771-5. [PMID: 29935305]
88	Fuca G, Galli G, Poggi M, et.al "Modulation of peripheral blood immune cells by early use of steroids and its association with clinical outcomes in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors." ESMO Open 4 (2019): e000457. [PMID: 30964126]
89	Horvat TZ, Adel NG, Dand TO, et.al "Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center." J Clin Oncol 33 (2015): 3193-8. [PMID: 26282644]
90	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
91	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
92	Product Information. Orimune (poliovirus vaccine, live, oral, trivalent). Lederle Laboratories, Philadelphia, PA.
93	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
94	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
95	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
96	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
97	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
98	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
99	Johansson C, Adamsson U, Stierner U, Lindsten T "Interaction by cholestyramine on the uptake of hydrocortisone in the gastrointestinal tract." Acta Med Scand 204 (1978): 509-12. [PMID: 735882]
100	Nekl KE, Aron DC "Hydrocortisone-colestipol interaction." Ann Pharmacother 27 (1993): 980-1. [PMID: 8364291]
101	Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.
102	Product Information. Questran (cholestyramine). Par Pharmaceutical Inc, Chestnut Ridge, NY.
103	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
104	Baer PA, Shore A, Ikeman RL "Transient fall in serum salicylate levels following intraarticular injection of steroid in patients with rheumatoid arthritis." Arthritis Rheum 30 (1987): 345-7. [PMID: 3566826]
105	Edelman J, Potter JM, Hackett LP "The effect of intra-articular steroids on plasma salicylate concentrations." Br J Clin Pharmacol 21 (1986): 301-7. [PMID: 3485989]
106	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
107	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
108	Legler UF, Benet LZ "Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives." Clin Pharmacol Ther 39 (1986): 425-9
109	Meffin PJ, Wing LM, Sallustio BC, Brooks PM "Alterations in prednisolone as a result of oral contraceptive use and dose." Br J Clin Pharmacol 17 (1984): 655-64
110	Frey BM, Schaad HJ, Frey FJ "Pharmacokinetic interaction of contraceptive steroids with prednisone and prednisolone." Eur J Clin Pharmacol 26 (1984): 505-11
111	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
112	Product Information. Gallium Citrate Ga-67 (gallium citrate 67 Ga (gallium citrate 67Ga)). Bristol-Myers Squibb, Princeton, NJ.
113	Product Information. Buphenyl (sodium phenylbutyrate). Horizon Pharma USA Inc, Northbrook, IL.
114	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
115	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
116	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
117	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
118	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
119	Product Information. AndroGel (testosterone). Unimed Pharmaceuticals, Buffalo Grove, IL.
120	Product Information. Oxandrin (oxandrolone). Bio-Tech, Levittown, PA.
121	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
122	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
123	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
124	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
125	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
126	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
127	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
128	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
129	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
130	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
131	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
132	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.
133	Product Information. Norditropin Cartridge (somatropin). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
134	Product Information. Nutropin (somatropin). Genentech, South San Francisco, CA.
135	Product Information. Protropin (somatrem). Genentech, South San Francisco, CA.
136	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
137	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
138	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
139	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
140	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
141	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
142	Black DM, Filak AT "Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection." J Fam Pract 28 (1989): 462-3. [PMID: 2703816]
143	Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4. [PMID: 3444801]
144	Product Information. EXUBERA (insulin inhalation, rapid acting). Pfizer U.S. Pharmaceuticals Group, New York, NY.
145	Ledford D, Apter A, Brenner AM, Rubin K, Prestwood K, Frieri M, Lukert B "Osteoporosis in the corticosteroid-treated patient with asthma." J Allergy Clin Immunol 102 (1998): 353-62
146	Anderton JM, Helm R "Multiple joint osteonecrosis following short-term steroid therapy. Case report." J Bone Joint Surg Am 64 (1982): 139-41
147	Taylor LJ "Multifocal avascular necrosis after short-term high-dose steroid therapy. A report of three cases." J Bone Joint Surg Br 66 (1984): 431-3
148	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
149	Lafforgue P, Monjanel-Mouterde S, Durand A, Catalin J, Acquaviva PC "Is there an interaction between low doses of corticosteroids and methotrexate in patients with rheumatoid arthritis? A pharmacokinetic study in 33 patients." J Rheumatol 20 (1993): 263-7. [PMID: 8474062]
150	Roenigk HH, Fowler-Bergfeld W, Curtis GH "Methotrexate for psoriasis in weekly oral doses." Arch Dermatol 99 (1969): 86-93. [PMID: 5761810]
151	Wolff JE, Hauch H, Kuhl J, Egeler RM, Jurgens H "Dexamethasone increases hepatotoxicity of MTX in children with brain tumors." Anticancer Res 18 (1998): 2895-900. [PMID: 9713483]
152	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
153	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
154	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
155	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
156	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
157	Pepping J "Echinacea." Am J Health Syst Pharm 56 (1999): 121-2
158	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
159	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
160	Product Information. Vitrase (hyaluronidase). Bausch and Lomb, Rochester, NY.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence