Details of Drug

Drug General Information (ID: D0207)
Drug Name	Brinzolamide (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Azopt; Birnzolamide; Alcon brand of brinzolamide; Allphar brand of brinzolamide; Brinzolamide [USAN]; AL 4862; AL04862; BZ1; AL-4862; Azopt (TN); Brinzolamide (BRZ); Brinzolamide (JAN/USP/INN); (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide; 2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R Click to Show/Hide
Disease Class	9C61: Glaucoma
Therapeutic Class	Ophthalmic Glaucoma Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H21N3O5S3
InChI	1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
InChIKey	HCRKCZRJWPKOAR-JTQLQIEISA-N
Canonical SMILES	CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
External Link
	Pubchem ID	68844
	CAS Number	138890-62-7
	CHEBI ID	3176
	TTD ID	D01MUR
	INTEDE ID	DR0229

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects BM013 Competitive binding of plasma proteins BM070 Increased risk of metabolic acidosis
Relation Graph

Full list of drugs interacting with Brinzolamide (ophthalmic)
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1], [2], [3]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Major		Inter Info	[1], [2], [3]
D0331		Choline salicylate	C12H19NO4	54686350	Major		Inter Info	[1], [2], [3]
D1272		Phenyl salicylate	C13H10O3	8361	Major		Inter Info	[1], [2], [3]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[1], [2], [3]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2], [3]
D1439		Salicylic acid (sodium)	C7H6O3	338	Major		Inter Info	[1], [2], [3]
Pharmacodynamic additive effects

References
1	Cowan RA, Hartnell GG, Lowdell CP, Baird IM, Leak AM "Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function." Br Med J (Clin Res Ed) 289 (1984): 347-8. [PMID: 6432091]
2	Sweeney KR, Chapron DJ, Brandt JL, Gomolin IH, Feig PU, Kramer PA "Toxic interaction between acetazolamide and salicylate: case reports and a pharmacokinetic explanation." Clin Pharmacol Ther 40 (1986): 518-24. [PMID: 3769383]
3	Sweeney KR, Chapron DJ, Kramer PA "Effect of salicylate on serum protein binding and red blood cell uptake of acetazolamide in vitro." J Pharm Sci 77 (1988): 751-6. [PMID: 3225768]