Details of Drug

Drug General Information (ID: D0204)
Drug Name	Brigatinib
Drug Type	Small molecule
Drug Synonymous	1197953-54-0; UNII-HYW8DB273J; Brigatinib [USAN]; ALUNBRIG; HYW8DB273J; Brigatinib (USAN); Brigatiib; Alunbrig (TN); Brigatinib [USAN:INN]; Brigatinib (AP26113); SCHEMBL11916361; KS-00000TSQ; EX-A775; MolPort-044-561-640; BDBM50185140; ZINC148723177; AKOS030257612; CS-4278; DB12267; HY-12857; AC-29958 Click to Show/Hide
Disease Class	2C25: Lung cancer; 2A90: Mature T-cell lymphoma
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C29H39ClN7O2P
InChI	1S/C29H39ClN7O2P/c1-35-15-17-37(18-16-35)21-11-13-36(14-12-21)22-9-10-24(26(19-22)39-2)33-29-31-20-23(30)28(34-29)32-25-7-5-6-8-27(25)40(3,4)38/h5-10,19-21H,11-18H2,1-4H3,(H2,31,32,33,34)
InChIKey	AILRADAXUVEEIR-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC
External Link
	Pubchem ID	68165256
	CAS Number	1197953-54-0
	TTD ID	D08PIE
	INTEDE ID	DR0228
	VARIDT ID	DR00368

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM051 Increased risk of bradycardia BM055 Increased risk of hepatotoxicity BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Brigatinib
Affected cellular transport
	Transporter inhibition					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[43], [9], [44], [45]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[9], [7], [37]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[9], [7], [37]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[9], [7], [37]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[9], [7], [37]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[9], [56]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[64]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[9], [7], [37]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[9], [7], [37]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[112]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[9], [7], [37]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[9], [7], [37]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[114], [115], [116]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[9], [7], [37]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[9], [7], [37]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[9], [7], [37]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[9], [7], [37]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[9], [7], [37]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[9], [7], [37]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[9], [7], [37]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[9], [7], [37]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[114], [126], [115], [116]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[9], [7], [37]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[9], [7], [37]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[9], [7], [37]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[9], [7], [37]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[9], [7], [37]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[9], [7], [37]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[9], [7], [37]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[9], [7], [37]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[9], [7], [37]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[9], [7], [37]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[9], [7], [37]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[9], [7], [37]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[9], [7], [37]
D1591		Tipiracil	C9H11ClN4O2	6323266	Moderate		Inter Info	[9], [7], [37]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[153]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[9], [7], [37]
D1617		Trametinib	C26H23FIN5O4	11707110	Moderate		Inter Info	[9], [7], [37]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[9], [7], [37]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[8], [9], [162]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[164]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[165]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[8], [9], [7]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[8], [9], [7]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[8], [9], [7]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[8], [9], [7]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[8], [9], [7]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[8], [9], [7]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[7]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[8], [9], [7]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[8], [9], [7]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[8], [9], [7]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[8], [9], [7]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[8], [9], [7]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[8], [9], [7]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[8], [9], [7]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[7]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[8], [9], [7]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[8], [9], [7]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[7]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[8], [9], [7]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[8], [9], [7]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[8], [9], [7]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[8], [9], [7]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[30]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[8], [9], [7]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[8], [9], [7]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[8], [9], [7]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[8], [9], [7]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[8], [9], [7]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[8], [9], [7]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[8], [9], [7]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[8], [9], [7]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[8], [9], [7]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[8], [9], [7]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[8], [9], [7]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[8], [9], [7]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[8], [9], [7]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[8], [9], [7]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[8], [9], [7]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[8], [9], [7]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[8], [9], [7]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[8], [9], [7]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[8], [9], [7]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[8], [9], [7]
D0715		Gemfibrozil	C15H22O3	3463	Minor		Inter Info	[7]
	CYP450 enzyme induction					Drug Num: 195
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[7]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[8], [9], [7]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[8], [9], [7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[8], [9], [7]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[8], [9], [7]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[8], [9], [7]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[8], [9], [7]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[22], [7]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[7]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[8], [9], [7]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[7]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[22], [7]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[7]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[8], [9], [7], [23]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[7]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[8], [9], [7]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[8], [9], [7]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[27]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[22], [7]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[7]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[8], [9], [7]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[8], [9], [7]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[22], [7]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[22], [7]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[7]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[7]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[7]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[7]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[8], [9], [7]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[8], [9], [7]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[7]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[7]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Major		Inter Info	[8], [9], [7]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[31]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[32]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[7]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[39], [40], [41], [42]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[7]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[8], [9], [7]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[7]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[8], [9], [7]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[51]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[8], [9], [7]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[52], [7], [53]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[7]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[9], [54], [55]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[7]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[9], [60]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[61], [62], [63]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[68]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[69]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[71], [72]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[8], [73]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[74]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[8], [9], [7]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[8], [9], [75]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[76]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[77]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[78], [61], [79], [8], [9], [80], [81], [82], [62], [83], [84], [85], [86], [87], [88], [89], [90], [91], [63]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[9], [92]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[8], [100]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[9], [101]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[8], [9], [7]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[8], [9], [7]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[102]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[7]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[103], [104], [105]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[7]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[8], [9], [7]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[8], [9], [7]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[78], [61], [79], [8], [9], [80], [81], [82], [62], [83], [84], [85], [86], [87], [88], [89], [90], [91], [63]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[106], [107]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[111]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[7]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[7]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[7]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[52], [7], [53]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[7]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[8], [9], [113]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[8], [9], [7]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[7]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[52], [7], [53]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[8], [9], [118]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[7]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[7]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[7]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[9], [119], [120], [121]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[119], [120], [121]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[7]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[7]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[8], [9], [7]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[8], [9], [7]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[123]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[124]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[7]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[8], [9], [118]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[8], [9], [118]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[7]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[7]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[7]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[7]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[52], [7], [53]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[7]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[7]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[7]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[7]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[8], [9], [7]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[78], [61], [79], [8], [9], [80], [81], [82], [62], [83], [84], [85], [86], [87], [88], [89], [90], [91], [63]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[7]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[7]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[125]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[7]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[8], [9], [7]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[7]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[7]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[7]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[78], [61], [79], [8], [9], [80], [81], [82], [62], [83], [84], [85], [86], [87], [88], [89], [90], [91], [63]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[7]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[7]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[7]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[8], [127]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[8], [9], [7]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[7]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[52], [7], [53]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[7]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[7]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[7]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[52], [7], [53]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[78], [61], [79], [8], [9], [80], [81], [82], [62], [83], [84], [85], [86], [87], [88], [89], [90], [91], [63]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[8], [9], [118]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[8], [9], [7]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[8], [9], [118]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[8], [9], [7]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[7]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[7]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[8], [9], [7]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[9], [131]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[8], [9], [7]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[7]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[132], [133], [134], [135]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[132], [133], [134]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[8], [9], [7]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[136]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[7]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[137], [8], [138], [139]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[7]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[7]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[7]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[7]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[7]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[8], [140], [9], [141]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[142]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[7]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[8], [9], [7]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[8], [9], [7]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[144]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[7]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[7]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[8], [9], [145], [146]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[7]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[8], [9], [7]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[8], [9], [7]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[147]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[7]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[8], [9], [7]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[8], [9], [148]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[8], [9], [145], [146]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[7]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[7]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[8], [9], [149]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[7]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[7]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[7]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[43], [9], [150], [151], [152]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[7]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[7]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[7]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[154], [8], [9], [155], [156]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[7]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[7]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[8], [9], [7]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[7]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[7]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[8], [9], [7]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[7]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[7]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[52], [7], [53]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[7]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[7]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[7]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[7]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[9], [158], [159], [160], [161]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[163]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[8], [9], [13]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [15]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[8], [16]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[20]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[9], [21]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[24]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[25], [26]
D1111		Natalizumab	NA	NA	Major		Inter Info	[28]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[25], [26]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[29]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[17], [36], [37]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[38]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[46], [47], [48]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[8], [9]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[70]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[70]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[46], [47], [48]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[117]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[70]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[122]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[129]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[130]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[46], [47], [48]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[9], [143]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[157]
	Increased risk of bradycardia					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[7]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[7]
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[7]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[7]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[7]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[7]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[7]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[7]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[7]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[7]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[7]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[7]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[7]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[7]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[7]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[7]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[7]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[7]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[7]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[7]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[7]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[7]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[7]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[7]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[7]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[7]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[7]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[7]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[7]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[7]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[7]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[7]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[7]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[7]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[7]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[7]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[7]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[7]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[7]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[7]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[7]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[7]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[7]
D1088		Moricizine	C22H25N3O4S	34633	Moderate		Inter Info	[7]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[7]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[7]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[7]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[7]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[7]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[7]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[7]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[7]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[7]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[7]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[7]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Moderate		Inter Info	[7]
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[7]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[7]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[7]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[7]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[7]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[7]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[7]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[7]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[7]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[7]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[7]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[7]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[7]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[7]
	Increased risk of hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[57], [58], [59]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[9], [14]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[33], [34], [35]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[33], [34], [35]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[33], [34], [35]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[33], [34], [35]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[33], [34], [35]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[33], [34], [35]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[33], [34], [35]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[33], [34], [35]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[33], [34], [35]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[33], [34], [35]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[33], [34], [35]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[33], [34], [35]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[33], [34], [35]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[33], [34], [35]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[33], [34], [35]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[33], [34], [35]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[33], [34], [35]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[33], [34], [35]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[33], [34], [35]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[33], [34], [35]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[33], [34], [35]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[33], [34], [35]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[33], [34], [35]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[33], [34], [35]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[33], [34], [35]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[33], [34], [35]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[33], [34], [35]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[33], [34], [35]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[33], [34], [35]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[33], [34], [35]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[33], [34], [35]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[33], [34], [35]
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[10], [11], [12]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[17], [8], [18]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[19]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[10], [11], [12]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[10], [11], [12]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[10], [11], [12]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[10], [11], [12]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[10], [11], [12]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[10], [11], [12]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[17], [49], [50]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[17], [49], [50]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[17], [49], [50]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[17], [49], [50]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[93], [17], [8], [94], [95], [96], [49], [97], [98], [99], [50]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[17], [49], [50]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[17], [49], [50]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[17], [49], [50]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[17], [49], [50]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[17], [49], [50]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[17], [49], [50]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[128]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[17], [49], [50]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[65], [66], [67]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[65], [66], [67]
	Diminish the response to diagnostic skin test antigens					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[108], [109], [110]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[108], [109], [110]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[108], [109], [110]

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117	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
118	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
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123	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
124	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
125	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
126	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
127	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
128	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
129	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
130	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
131	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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134	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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