Details of Drug

Drug General Information (ID: D0194)
Drug Name	Bosentan
Drug Type	Small molecule
Drug Synonymous	Actelion; Bosentanum; Tracleer; Bosentan (INN); KS-5062; Ro 47-0203; Tracleer (TN); Bosentan [USAN:INN:BAN]; Ro 47-0203/039; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039; P-tert-Butyl-N-[6-(2-hydroxyethoxy); P-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide; 4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide Click to Show/Hide
Disease Class	BB01: Pulmonary hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C27H29N5O6S
InChI	1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
InChIKey	GJPICJJJRGTNOD-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
External Link
	Pubchem ID	104865
	CAS Number	147536-97-8
	CHEBI ID	51450
	TTD ID	D0U4CE
	INTEDE ID	DR0222
	VARIDT ID	DR00288

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM042 Additive hypotensive effects BM055 Increased risk of hepatotoxicity BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Bosentan
Affected cellular transport
	Transporter inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [18], [19]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [18], [19]
D0155		Bempedoic acid	C19H36O5	10472693	Moderate		Inter Info	[121], [122]
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[159], [160], [161]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[163], [12], [10], [164], [165]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[10], [167]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[220]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[48]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[19]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[91]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[10], [1], [99], [100], [18], [101], [102], [103], [104], [105], [106]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[10], [1], [99], [100], [18], [101], [102], [103], [104], [105], [106]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[19]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[125], [19], [126]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[19]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[19]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[19]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[19]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[19]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[19]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[142], [143]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[19]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[19]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[10], [1], [217]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[19]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[10], [1], [99], [100], [18], [101], [102], [103], [104], [105], [106]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[19]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[19]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[19]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[19]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[19]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[19]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[19]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[10], [1], [246]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[19]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[10], [1], [19]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[261], [262]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[19]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[19]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[19]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[19]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[10], [1], [99], [100], [18], [101], [102], [103], [104], [105], [106]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[125], [19], [126]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[19]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[10], [1], [19]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[19]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[19]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[19]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[10], [1], [19]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[19]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[19]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[19]
	CYP450 enzyme induction					Drug Num: 288
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [2]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[3], [4]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1], [5]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[6], [7], [8]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[9]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[10], [1], [11]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[12], [10], [1], [13], [14], [15], [6], [7], [8], [16]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[17]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[10], [1], [20]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[1], [21]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[1]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[22], [19], [23]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[1], [24], [25]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[26], [19]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[27]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[28]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[29]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[22], [19], [23]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [30]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[12], [10], [1], [13], [14], [15], [6], [7], [8], [16]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[31]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[34], [35], [36]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[1], [37], [38]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[12], [10], [1], [13], [14], [15], [6], [7], [8], [16]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[39]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[42], [43]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[45]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[46]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[47]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[22], [19], [23]
D1011		Mestranol	C21H26O2	6291	Major		Inter Info	[22], [19], [23]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[10], [50]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[22], [19], [23]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[22], [19], [23]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[26], [19]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[10], [1], [51]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[12], [10], [1], [13], [14], [15], [6], [7], [8], [16]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[1], [52]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[54]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[55]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1], [57]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[58]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [59]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[60]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[61]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[1], [63], [53]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[64]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[65]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[66]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[26], [19]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[12], [10], [1], [13], [14], [15], [6], [7], [8], [16]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[79]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[19]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[19]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[19]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[19]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[19]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[92]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[93]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[94], [95], [96], [97]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[98]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[107], [19]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[1], [108]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[109]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[113]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[114], [115]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[116]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[117], [118]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[10], [1], [119]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[19]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[19]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[120]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[19]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[1], [123], [124]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[19]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[128]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[19]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[129]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[10], [1]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[132]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[19]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[19]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[19]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[19]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[134], [135], [19]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[134], [135], [19]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[136]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[137], [1], [138]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [139]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[140]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[10], [1], [141]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[144], [145]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[19]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[19]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[146], [10], [1]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[147], [148], [149], [150], [151]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[19]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [152], [153], [154]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[152], [153], [154]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[155]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[10], [156]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[157]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[158]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[162]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[10], [1], [166]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[168]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[10], [1], [169]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[10], [1], [169]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[19]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [26], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [23], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [26], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [23], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[174], [184], [207]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [26], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [23], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[174], [184], [207]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[19]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[19]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[10], [1], [215]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[216]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[218]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[219]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[19]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[19]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[10], [1]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[221]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[222]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[19]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[19]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[19]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[19]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[19]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[19]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[19]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[225], [226], [231]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[1], [239]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[19]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[240]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[241]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[10], [1], [242]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[10], [1], [243]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[244]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[245]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[19]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[19]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[250]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[19]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[10], [1], [253]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[254]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[255], [256]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[10], [257]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[19]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[19]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[19]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[259], [260]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[117], [118]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[263]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[19]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[19]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[19]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[19]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[19]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[268]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[269]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[270]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[19]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[271], [272], [273], [274]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[275]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[1], [135]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[281]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[19]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[19]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[282]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[283], [10], [284], [285]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[19]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[19]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[19]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[10], [286], [287], [288], [289]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [26], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [23], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[19]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[290]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[294], [295], [296]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[10], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[297], [298]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[10], [137], [1], [299]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[300]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[10], [301]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[302]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[1], [303]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [304]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[305]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[306]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[19]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[10], [1], [307]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[19]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[10], [1], [308], [309]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[310]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[10], [1], [311]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[10], [1], [312], [311]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[10], [1], [313]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[314]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[10], [1], [308], [309]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[1], [315], [316]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[317], [318], [319], [320]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[321], [322]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [323]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[10], [1], [324]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[19]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[134], [135], [19]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[19]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[12], [1], [325], [326], [327]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[10], [328]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[19]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[19]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1], [329]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[19]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[19]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[19]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[331]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[332]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1], [333]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[19]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[334]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[19]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[335]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[19]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[336]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[107], [19]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[19]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[19]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[19]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[337], [338], [339]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[340]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[19]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[146], [10], [137], [1], [341], [342], [343]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [26], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [23], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[19]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[19]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[344]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[345], [107], [19]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[10], [1], [169]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[178], [346], [347], [157], [23]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[19]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[19]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[349], [350]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[19]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[351]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[349], [352]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[19]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[10], [1], [99], [100], [18], [101], [102], [103], [104], [105], [106]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[19]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[19]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[19]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[19]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[174], [184], [207]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[10], [1], [169]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[10], [1], [169]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[355], [356], [357], [358]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[359]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[10], [1], [99], [100], [18], [101], [102], [103], [104], [105], [106]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[10], [1], [19]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[19]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[10], [1]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[19]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [26], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [23], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[174], [184], [207]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[360], [361], [8], [362], [363], [364]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[365], [19]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[10], [1], [311]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[366]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[19]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[19]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[369], [10], [1], [318], [370]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[19]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[19]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[134], [135], [19]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[19]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[19]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[1], [373], [374], [375]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[320]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[1], [376], [377], [378], [379]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[380]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[381]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[382]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[383]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[384], [385], [161]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[386], [387], [388], [389]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[390], [391]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[56]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[62]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[110], [111], [112]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[10], [1], [130]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[10], [1], [130]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[10], [1], [130]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[1], [251], [252]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[265], [266], [267]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[280]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[110], [111], [112]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[110], [111], [112]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[353], [354]
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0730		Glyburide	C23H28ClN3O5S	3488	Major		Inter Info	[19], [32], [33]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[12], [40], [41]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[44]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[49]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[53]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[12], [40], [41]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[80], [81], [82], [10], [1], [83], [84], [85], [86], [87], [88], [89], [90]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[80], [81], [82], [10], [1], [83], [84], [85], [86], [87], [88], [89], [90]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[127]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[80], [81], [82], [10], [1], [83], [84], [85], [86], [87], [88], [89], [90]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1], [131]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[133]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[223]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[1], [258]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[264]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[276], [277], [278], [279]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[10], [1], [291], [292], [293]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [330]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[10], [1], [348]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[276], [277], [278], [279]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[276], [277], [278], [279]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[80], [81], [82], [10], [1], [83], [84], [85], [86], [87], [88], [89], [90]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[367], [368]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[247], [248], [249]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[371], [372]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
3	Pithavala YK, Tortorici M, Toh M, et al "Effect of rifampin on the pharmacokinetics of axitinib (AG-013736) in Japanese and Caucasian healthy volunteers." Cancer Chemother Pharmacol 65 (2010): 563-70. [PMID: 19603168]
4	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
5	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
6	Product Information. Mycobutin (rifabutin). Pharmacia and Upjohn, Kalamazoo, MI.
7	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
8	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
9	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
10	Cerner Multum, Inc. "Australian Product Information.".
11	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
12	Canadian Pharmacists Association.
13	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
14	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
15	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
16	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
17	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
18	Product Information. Evotaz (atazanavir-cobicistat). Bristol-Myers Squibb, Princeton, NJ.
19	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
20	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
21	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
22	Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
23	Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8. [PMID: 9385296]
24	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
25	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
26	Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
27	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
28	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
29	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
30	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
31	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
32	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
33	Van Giersbergen PL, Treiber A, Clozel M, Bodin F, Dingemanse J "In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide." Clin Pharmacol Ther 71 (2002): 253-62.[PMID: 11956508]
34	Mir F, Pearce RE, Baig-Ansari N, et al. Serum amoxicillin levels in young infants (0-59 days) with sepsis treated with oral amoxicillin.?Arch Dis Child. 2020;105(12):1208-1214. [PMID: 32404437]
35	Neu HC "Antimicrobial activity and human pharmacology of amoxicillin." J Infect Dis 129 (1974): s123-31. [PMID: 4601187]
36	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
37	Kiechel JR, Lavene D, Guerret M, Comoy E, Godin M, Fillastre JP "Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure." Eur J Clin Pharmacol 25 (1983): 463-6. [PMID: 6360692]
38	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
39	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
40	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
41	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
42	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
43	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
44	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
45	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
46	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
47	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
48	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
49	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
50	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
51	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
52	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
53	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
54	Product Information. Pretomanid (pretomanid). The Global Alliance for TB Drug Development, New York, NY.
55	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
56	Product Information. Trodelvy (sacituzumab govitecan). Immunomedics, Morris Plains, NJ.
57	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
58	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
59	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
60	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
61	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
62	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
63	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
64	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
65	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
66	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
67	Altice FL, Friedland GH, Cooney EL "Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone." AIDS 13 (1999): 957-62. [PMID: 10371177]
68	Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
69	Bending MR, Skacel PO "Rifampicin and methadone withdrawal." Lancet 1 (1977): 1211. [PMID: 68314]
70	Finelli PF "Phenytoin and methadone tolerance." N Engl J Med 294 (1976): 227. [PMID: 1244546]
71	Holmes VF "Rifampin-induced methadone withdrawal in AIDS." J Clin Psychopharmacol 10 (1991): 443-4. [PMID: 2286719]
72	Kreek MJ, Garfield JW, Gutjahr CL, Giusti LM "Rifampin-induced methadone withdrawal." N Engl J Med 294 (1976): 1104-6. [PMID: 1256526]
73	Liu S-J, Wang RI "Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome." Am J Psychiatry 141 (1984): 1287-8. [PMID: 6486271]
74	Otero MJ, Fuertes A, Sanchez R, Luna G "Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert." AIDS 13 (1999): 1004-5. [PMID: 10371190]
75	Pinzani V, Faucherre V, Peyriere H, Blayac JP "Methadone withdrawal symptoms with nevirapine and efavirenz." Ann Pharmacother 34 (2000): 405-7. [PMID: 10917395]
76	Product Information. Diskets (methadone). Cebert Pharmaceuticals Inc, Birmingham, AL.
77	Raistrick D, Hay A, Wolff K "Methadone maintenance and tuberculosis treatment." BMJ 313 (1996): 925-6. [PMID: 8876100]
78	Tong TG, Pond SM, Kreek MJ, et al "Phenytoin-induced methadone withdrawal." Ann Intern Med 94 (1981): 349-51. [PMID: 7224382]
79	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
80	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
81	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
82	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
83	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
84	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
85	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
86	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
87	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
88	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
89	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
90	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
91	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
92	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
93	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
94	Kharasch ED, Thummel KE "Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?" Anesth Analg 76 (1993): 1033-9. [PMID: 8484504]
95	Koehntop DE, Noormohamed SE, Fletcher CV "Effects of long-term drugs on alfentanil clearance in patients undergoing renal transplantation." Pharmacotherapy 14 (1994): 592-9. [PMID: 7997393]
96	Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED "Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism." Drug Metab Dispos 23 (1995): 490-6. [PMID: 7600917]
97	Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle A, Cox K "The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions." Anesthesiology 87 (1997): 36-50. [PMID: 9232132]
98	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
99	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
100	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
101	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
102	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
103	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
104	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
105	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
106	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
107	Murphey LM, Hood EH "Bosentan and warfarin interaction." Ann Pharmacother 37 (2003): 1028-31. [PMID: 12841813]
108	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
109	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
110	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
111	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
112	Walters TR "Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: a review of safety, efficacy, dose response, and dosing studies." Surv Ophthalmol 41 ( Suppl (1996): s19-26
113	Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
114	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
115	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
116	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
117	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
118	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
119	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
120	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
121	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
122	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
123	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
124	Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
125	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
126	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
127	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
128	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
129	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
130	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
131	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
132	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
133	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
134	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
135	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
136	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
137	Cerner Multum, Inc. "Canadian Product Information.".
138	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
139	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
140	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
141	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
142	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
143	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
144	Borin MT, Chambers JH, Carel BJ, Gagnon S, Freimuth WW "Pharmacokinetic study of the interaction between rifampin and delavirdine mesylate." Clin Pharmacol Ther 61 (1997): 544-53. [PMID: 9164416]
145	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
146	Caraco Y, Sheller J, Wood AJ "Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects." J Pharmacol Exp Ther 281 (1997): 330-6. [PMID: 9103514]
147	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
148	Baker SD "Drug interactions with the taxanes." Pharmacotherapy 17(5 Pt 2) (1997): s126-32. [PMID: 9322879]
149	Komoroski BJ, Parise RA, Egorin MJ, Strom SC, Venkataramanan R "Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures." Clin Cancer Res 11(19 Pt 1) (2005): 6972-9. [PMID: 16203790]
150	McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110. [PMID: 3063497]
151	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
152	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
153	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
154	Kaytser V, Zhang P. Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.?Front Neurol. 2021;12:632830. [PMID: 33679591]
155	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
156	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
157	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
158	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
159	Product Information. Cozaar (losartan). Merck &amp Co, Inc, West Point, PA.
160	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
161	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
162	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
163	Allred AJ, Bowen CJ, Park JW, et al. "Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers." Br J Clin Pharmacol 72 (2011): 321-9. [PMID: 21434975]
164	Kalliokoski A, Niemi M "Impact of OATP transporters on pharmacokinetics." Br J Pharmacol 158 (2009): 693-705. [PMID: 19785645]
165	Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC.
166	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
167	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
168	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
169	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
170	Baciewicz AM "Oral contraceptive drug interactions." Ther Drug Monit 7 (1985): 26-35. [PMID: 2859674]
171	Baciewicz AM, Self TH "Rifampin drug interactions." Arch Intern Med 144 (1984): 1667-71. [PMID: 6380442]
172	Back DJ, Bates M, Bowden A, et al "The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy." Contraception 22 (1980): 495-503. [PMID: 7471739]
173	Back DJ, Breckenridge AM, Crawford FE, et al. "The effect of rifampicin on the pharmacokinetics of ethynylestradiol in women." Contraception 21 (1980): 135-43. [PMID: 7189454]
174	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
175	Back DJ, Orme ML "Pharmacokinetic drug interactions with oral contraceptives." Clin Pharmacokinet 18 (1990): 472-84. [PMID: 2191822]
176	Barditch-Crovo P, Trapnell CB, Ette E, et al "The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive." Clin Pharmacol Ther 65 (1999): 428-38. [PMID: 10223781]
177	Bolt HM, Bolt M, Kappus H "Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinyloestradiol in man." Acta Endocrinol (Copenh) 85 (1977): 189-97. [PMID: 577076]
178	Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6. [PMID: 1558427]
179	Cote J "Interaction of griseofulvin and oral contraceptives." J Am Acad Dermatol 22 (1990): 124-5. [PMID: 2298948]
180	Coulam CB, Annegers JF "Do anticonvulsants reduce the efficacy of oral contraceptives?" Epilepsia 20 (1979): 519-26. [PMID: 477641]
181	Crawford P, Chadwick DJ, Martin C, et al "The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids." Br J Clin Pharmacol 30 (1990): 892-6. [PMID: 2126946]
182	Curran MA "Drug interactions with the pill." Med J Aust 144 (1986): 670-1. [PMID: 3086681]
183	D'Arcy PF "Drug interactions with oral contraceptives." Drug Intell Clin Pharm 20 (1986): 353-62. [PMID: 3519141]
184	Dickinson BD, Altman RD, Nielsen NH, Sterling ML "Drug interactions between oral contraceptives and antibiotics." Obstet Gynecol 98(5 Pt 1) (2001): 853-60. [PMID: 11704183]
185	D'Arcy PF. Drug interactions with oral contraceptives. Drug Intell Clin Pharm. 1986;20(5):353-362. [PMID: 3519141]
186	Durr D, Stieger B, KullakUblick GA, Rentsch KM, Steinert HC, Meier PJ, Fattinger K "St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4." Clin Pharmacol Ther 68 (2000): 598-604. [PMID: 11180019]
187	Furlan AJ, Rothner AD "Anti-epileptic drugs and failure of oral contraceptives." Lancet 1 (1974): 1113. [PMID: 4135275]
188	Gorski JC, Hamman MA, Wang Z, Vasvada N, Huang S, Hall SD "The effect of St. John's wort on the efficacy of oral contraception." Clin Pharmacol Ther 71 (2002): P25. [PMID: 14663455]
189	Hall SD, Wang Z, Huang SM, et al. "The interaction between St John's wort and an oral contraceptive." Clin Pharmacol Ther 74 (2003): 525-35. [PMID: 14663455]
190	Halpenny O, Bye A, Cranny A, Feely J, Daly PA "Influence of aminoglutethimide on plasma levels of medroxyprogesterone acetate." Med Oncol Tumor Pharmacother 7 (1990): 241-7. [PMID: 2149401]
191	Janz D, Schmidt D "Letter: Anti-epileptic drugs and failure of oral contraceptives." Lancet 1 (1974): 1113. [PMID: 4135275]
192	Klosterskov Jensen P, Saano V, Haring P, Svenstrup B, Menge GP "Possible interaction between oxcarbazepine and an oral contraceptive." Epilepsia 33 (1992): 1149-52. [PMID: 1464278]
193	Laengner H, Detering K "Letter: Anti-epileptic drugs and failure of oral contraceptives." Lancet 2 (1974): 600. [PMID: 4140317]
194	LeBel M, Masson E, Guilbert E, Colborn D, Paquet F, Allard S, Vallee F, Narang PK "Effects of rifabutin and rifampicin on the pharmacokinetics of ethinylestradiol and norethindrone." J Clin Pharmacol 38 (1998): 1042-50. [PMID: 9824786]
195	Mattson RH, Cramer JA, Darney PD, Naftolin F "Use of oral contraceptives by women with epilepsy." JAMA 256 (1986): 238-40. [PMID: 3723710]
196	McDaniel PA, Caldroney RD "Oral contraceptives and griseofulvin interaction." Drug Intell Clin Pharm 20 (1986): 384. [PMID: 3709350]
197	Michalets EL "Update: clinically significant cytochrome P-450 drug interactions." Pharmacotherapy 18 (1998): 84-112. [PMID: 9469685]
198	Mumford JP "Letter: Drugs affecting oral contraceptives." Br Med J 2 (1974): 333-4. [PMID: 4827122]
199	Nocke-finck L "Effects of rifampicin on menstral cycle and on estrogen excretion in patients taking oral contraceptives." JAMA 226 (1973): 378. [PMID: 4580141]
200	Notelovitz M, Tjapkes J, Ware M "Interaction between estrogen and dilantin in a menopausal woman." N Engl J Med 304 (1981): 788-9. [PMID: 6258075]
201	Pfrunder A, Schiesser M, Gerber S, Haschke M, Bitzer J, Drewe J "Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial." Br J Clin Pharmacol 56 (2003): 683-90. [PMID: 14616430]
202	Product Information. Premarin (conjugated estrogens). Wyeth-Ayerst Laboratories, Philadelphia, PA.
203	Murphy PA. St. John's wort and oral contraceptives: reasons for concern?.?J Midwifery Womens Health. 2002;47(6):447-450. doi:10.1016/s1526-9523(02)00321-5. [PMID: 12484666]
204	Skolnick JL, Stoler BS, Katz DB, Anderson WH "Rifampin, oral contraceptives, and pregnancy." JAMA 236 (1976): 1382. [PMID: 989097]
205	Szoka PR, Edgren RA "Drug interactions with oral contraceptives: compilation and analysis of an adverse experience report database." Fertil Steril 49 (1988): s31-8. [PMID: 3282933]
206	Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception. Br J Clin Pharmacol 55 (2003): 112-113. [PMID: 12534648]
207	van Dijke CP, Weber JC "Interaction between oral contraceptives and griseofulvin." Br Med J (Clin Res Ed) 288 (1984): 1125-6. [PMID: 2143563]
208	Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65. [PMID: 1559307]
209	Weaver K, Glasier A "Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill: a literature review." Contraception 59 (1999): 71-8. [PMID: 10361620]
210	Weber JC "Interaction between oral contraceptives and griseofulvin." Br Med J 288 (1984): 1125-6. [PMID: 6424759]
211	Weisberg E "Interactions between oral contraceptives and antifungals antibacterials - Is contraceptive failure the result?." Clin Pharmacokinet 36 (1999): 309-13. [PMID: 10384856]
212	Wilbur K, Ensom MHH "Pharmacokinetic drug interactions between oral contraceptives and second-generation anticonvulsants." Clin Pharmacokinet 38 (2000): 355-65. [PMID: 10803456]
213	Zachariassen RD "Loss of oral contraceptive efficacy by concurrent antibiotic administration." Women Health 22 (1994): 17-26. [PMID: 7900401]
214	Lundgren S, Lonning PE, Aakvaag A, Kvinnsland S, Lnning PE "Influence of aminoglutethimide on the metabolism of medroxyprogesterone acetate and megestrol acetate in postmenopausal patients with advanced breast cancer." Cancer Chemother Pharmacol 27 (1990): 101-5. [PMID: 2249324]
215	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
216	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
217	Product Information. Antara (fenofibrate). Lupin Pharmaceuticals Inc, Baltimore, MD.
218	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
219	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
220	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
221	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
222	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
223	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
224	Crews KR, Stewart CF, Jones-Wallace D, et al "Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy." Clin Cancer Res 8 (2002): 2202-9. [PMID: 12114421]
225	Di YM, Li CG, Xue CC, Zhou SF "Clinical drugs that interact with St. John's wort and implication in drug development." Curr Pharm Des 14 (2008): 1723-42. [PMID: 18673195]
226	Friedman HS, Petros WP, Friedman AH, et al "Irinotecan therapy in adults with recurrent or progressive malignant glioma." J Clin Oncol 17 (1999): 1516-25. [PMID: 10334539]
227	Innocenti F, Undevia SD, Ramirez J, et al. "A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital." Clin Pharmacol Ther 76 (2004): 490-502. [PMID: 15536463]
228	Kuhn JG "Influence of anticonvulsants on the metabolism and elimination of irinotecan. A North American Brain Tumor Consortium preliminary report." Oncology (Williston Park 16(8 Suppl 7) (2002): 33-40. [PMID: 12199631]
229	Hu ZP, Yang XX, Chen X, et al. A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.?Curr Drug Metab. 2007;8(2):157-171. [PMID: 17305494]
230	Mathijssen RH, Verweij J, De Bruijn P, Loos WJ, Sparreboom A "Effects of St. John's Wort on Irinotecan Metabolism." J Natl Cancer Inst 94 (2002): 1247-9. [PMID: 12189228]
231	Minami H, Lad TE, Nicholas MK, Vokes EE, Ratain MJ "Pharmacokinetics and pharmacodynamics of 9-aminocamptothecin infused over 72 hours in phase II studies." Clin Cancer Res 5 (1999): 1325-30. [PMID: 10389915]
232	Murry DJ, Cherrick I, Salama V, et al. "Influence of phenytoin on the disposition of irinotecan: a case report." J Pediatr Hematol Oncol 24 (2002): 130-3. [PMID: 11990699]
233	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
234	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
235	Hofland KF, Hansen S, Sorensen M, et al. Neoadjuvant bevacizumab and irinotecan versus bevacizumab and temozolomide followed by concomitant chemoradiotherapy in newly diagnosed glioblastoma multiforme: A randomized phase II study.?Acta Oncol. 2014;53(7):939-944. [PMID: 24456504]
236	Santos A, Zanetta S, Cresteil T, et al "Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans." Clin Cancer Res 6 (2000): 2012-20. [PMID: 10815927]
237	Yonemori K, Takeda Y, Toyota E, Kobayashi N, Kudo K "Potential interactions between irinotecan and rifampin in a patient with small-cell lung cancer." Int J Clin Oncol 9 (2004): 206-9. [PMID: 15221608]
238	Zamboni WC, Gajjar AJ, Heideman RL, et al "Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma." Clin Cancer Res 4 (1998): 783-9. [PMID: 9533548]
239	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
240	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
241	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
242	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
243	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
244	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
245	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
246	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
247	Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age." Lancet 2 (1987): 821-4. [PMID: 2889032]
248	Cumming AM "Metabolic effects of licorice." Br Med J 1 (1977): 906
249	Epstein MT, Espiner EA, Donald RA, Hughes H "Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects." Br Med J 1 (1977): 488-90
250	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
251	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
252	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
253	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
254	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
255	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
256	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
257	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
258	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
259	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
260	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
261	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
262	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
263	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
264	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
265	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
266	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
267	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
268	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
269	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
270	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
271	Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
272	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
273	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
274	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
275	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
276	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
277	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
278	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
279	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
280	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
281	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
282	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
283	Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
284	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
285	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
286	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
287	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
288	Quetiapine for schizophrenia. Med Lett Drugs Ther 39 (1997): 117-8. [PMID: 9422044]
289	Wong YWJ, Yeh C, Thyrum PT "The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine." J Clin Psychopharmacol 21 (2001): 89-93. [PMID: 11199955]
290	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
291	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
292	Gilead Sciences, Inc "About Remdesivir.".
293	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
294	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
295	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT "Rifampin decreases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 68 (2000): 495-500. [PMID: 11103752]
296	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
297	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
298	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
299	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
300	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
301	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
302	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
303	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
304	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
305	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
306	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
307	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
308	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
309	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
310	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
311	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
312	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
313	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
314	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
315	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
316	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
317	Biochem Pharmacol "Variable contribution of cytochromes P450 2D6, 2C9, and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes." Biochem Pharmacol 53 (1997): 171-8. [PMID: 9037249]
318	Kivisto KT, Villikka K, Nyman L, Anttila M, Neuvonen PJ "Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin." Clin Pharmacol Ther 64 (1998): 648-54. [PMID: 9871429]
319	Lien EA, Anker G, Lonning PE, et al "Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide." Cancer Res 50 (1990): 5851-7. [PMID: 2393854]
320	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
321	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
322	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
323	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
324	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
325	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
326	Teng R, Mitchell P, Butler K "Effect of rifampicin on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy subjects." Eur J Clin Pharmacol 69 (2013): 877-83. [PMID: 23093043]
327	Weeks P, Sieg A, Vahdat K, Raissi F, Nathan S "Improved ticagrelor antiplatelet effect on discontinuation of phenytoin." Ann Pharmacother 48 (2014): 644-7. [PMID: 24477376]
328	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
329	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
330	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
331	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
332	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
333	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
334	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
335	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
336	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
337	Kivisto KT, Lamberg TS, Neuvonen PJ "Interactions of buspirone with itraconazole and rifampicin: Effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone." Pharmacol Toxicol 84 (1999): 94-7. [PMID: 10068153]
338	Lamberg TS, Kivisto KT, Neuvonen PJ "Concentrations and effects of buspirone are considerably reduced by rifampicin." Br J Clin Pharmacol 45 (1998): 381-5. [PMID: 9578186]
339	Product Information. Buspar (buspirone). Bristol-Myers Squibb, Princeton, NJ.
340	Product Information. Cancidas (caspofungin) Merck & Co, Inc, West Point, PA.
341	Product Information. Acetaminophen-Codeine Phosphate (acetaminophen-codeine). Qualitest Pharmaceuticals Inc, Huntsville, ON.
342	Product Information. Codeine Sulfate (codeine). Lannett Company Inc, Philadelphia, PA.
343	Product Information. Tuzistra XR (chlorpheniramine-codeine). Vernalis Pharmaceuticals Inc, Morristown, NJ.
344	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
345	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
346	Lledo P, Abrams SM, Johnston A, Patel M, Pearson RM, Turner P. Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine. Eur J Clin Pharmacol. 1993;44(1):63-67. [PMID: 8436157]
347	Product Information. Cardizem (diltiazem). Hoechst Marion-Roussel Inc, Kansas City, MO.
348	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
349	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
350	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
351	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
352	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
353	Leenen FH, Smith DL, Unger WP "Topical minoxidil: cardiac effects in bald men." Br J Clin Pharmacol 26 (1988): 481-5. [PMID: 3191000]
354	Product Information. Rogaine (minoxidil topical). Johnson and Johnson/McNeil Consumer, Fort Washington, PA.
355	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
356	Sitsen JM, Maris FA, Timmer CJ "Drug-drug interaction studies with mirtazapine and carbamazepine in healthy male subjects." Eur J Drug Metab Pharmacokinet 26 (2001): 109-21. [PMID: 11554425]
357	Spaans E, Van Den Heuvel MW, Schnabel PG, et al. "Concomitant use of mirtazapine and phenytoin: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 58 (2002): 423-9. [PMID: 12242602]
358	Timmer CJ, Sitsen JMA, Delbressine LP "Clinical pharmacokinetics of mirtazapine." Clin Pharmacokinet 38 (2000): 461-74. [PMID: 10885584]
359	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
360	Fabre C, Criddle J, Nolder D, Klein JL "Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin." Trans R Soc Trop Med Hyg 99 (2005): 871-3. [PMID: 16099004]
361	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
362	Pukrittayakamee S, Prakongpan S, Wanwimolruk S, Clemens R, Looareesuwan S, White NJ "Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria." Antimicrob Agents Chemother 47 (2003): 1509-1513. [PMID: 12709315]
363	Twum-Barima Y, Carruthers SG "Quinidine-rifampin interaction." N Engl J Med 304 (1981): 1466-9. [PMID: 7231477]
364	Wanwimolruk S, Kang W, Coville PF, Viriyayudhakorn S, Thitiarchakul S "Marked enhancement by rifampicin and lack of effect of isoniazid on the elimination of quinine in man." Br J Clin Pharmacol 40 (1995): 87-91. [PMID: 8527275]
365	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
366	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
367	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
368	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
369	Berthou F, Dreano Y, Belloc C, Kangas L, Gautier JC, Beaune P "Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes." Biochem Pharmacol 47 (1994): 1883-95. [PMID: 8204106]
370	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
371	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
372	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
373	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
374	Villikka K, Kivisto KT, Luurila H, Neuvonen PJ "Rifampin reduces plasma concentrations and effects of zolpidem." Clin Pharmacol Ther 62 (1997): 629-34. [PMID: 9433391]
375	Vlase L, Popa A, Neag M, Muntean D, Baldea I, Leucuta SE "Pharmacokinetic Interaction Between Zolpidem and Carbamazepine in Healthy Volunteers." J Clin Pharmacol (2010):. [PMID: 21098143]
376	Hellmann A, Rule S, Walewski J, et al. "Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or Non-Hodgkin's lymphoma." Clin Pharmacokinet 50 (2011): 781-91. [PMID: 22087865]
377	Pekol T, Daniels JS, Labutti J, et al "Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites." Drug Metab Dispos 33 (2005): 771-7. [PMID: 15764713]
378	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
379	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
380	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
381	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
382	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
383	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
384	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
385	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
386	Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95. [PMID: 5428253]
387	Perucca E, Richens A "Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients." Br J Clin Pharmacol 8 (1979): 21-31. [PMID: 552293]
388	Perucca E, Ruprah M, Richens A, Park BK, Betteridge DJ, Hedges AM "Effect of low-dose phenobarbitone on five indirect indices of hepatic microsomal enzyme induction and plasma lipoproteins in normal subjects." Br J Clin Pharmacol 12 (1981): 592-6. [PMID: 6117310]
389	Reichel C, Skodra T, Nacke A, Spengler U, Sauerbruch T "The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans." Br J Clin Pharmacol 46 (1998): 535-9. [PMID: 9862241]
390	Miceli JJ, Anziano RJ, Robarge L, Hansen RA, Laurent A "The effect of carbamazepine on the steady-state pharmacokinetics of ziprasidone in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s65-70. [PMID: 10771457]
391	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence