Details of Drug

Drug General Information (ID: D0182)
Drug Name	Binimetinib
Drug Type	Small molecule
Drug Synonymous	606143-89-9; Binimetinib; MEK162; MEK-162; ARRY-438162; 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; ARRY 162; UNII-181R97MR71; Binimetinib (MEK162, ARRY-162, ARRY-438162); 181R97MR71; MEK162 (ARRY-162, ARRY-438162); 6-(4-bromo-2-fluorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide; Binimetinib [USAN:INN]; MEK 162; ARRY 438162; MEK162(Binimetinib); Binimetinib (JAN/USAN); D0C4LF; NVP-ME Click to Show/Hide
Disease Class	2C30: Melanoma
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C17H15BrF2N4O3
InChI	1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey	ACWZRVQXLIRSDF-UHFFFAOYSA-N
Canonical SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
External Link
	Pubchem ID	10288191
	CAS Number	606143-89-9
	CHEBI ID	145371
	TTD ID	D0C4LF
	INTEDE ID	DR0214
	VARIDT ID	DR01336

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM019 UGT inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM047 Additive thrombogenic effects BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity
Relation Graph

Full list of drugs interacting with Binimetinib
Affected cellular transport
	Transporter inhibition					Drug Num: 91
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[21], [2], [46]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[21], [2], [46]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[21], [2], [46]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[21], [2], [46]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[21], [2], [46]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[21], [2], [46]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[21], [2], [46]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[21], [2], [46]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[21], [2], [46]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[21], [2], [46]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[21], [2], [46]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[21], [2], [46]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[21], [2], [46]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[21], [2], [46]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[21], [2], [46]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[21], [2], [46]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[21], [2], [46]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[21], [2], [46]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[21], [2], [46]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[21], [2], [46]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[21], [2], [46]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[21], [2], [46]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[21], [2], [46]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[21], [2], [46]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[21], [2], [46]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[21], [2], [46]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[21], [2], [46]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[21], [2], [46]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[21], [2], [46]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[21], [2], [46]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[21], [2], [46]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[21], [2], [46]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[21], [2], [46]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[21], [2], [46]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[21], [2], [46]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[21], [2], [46]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[21], [2], [46]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[21], [2], [46]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[21], [2], [46]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[21], [2], [46]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[21], [2], [46]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[21], [2], [46]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[21], [2], [46]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[21], [2], [46]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[21], [2], [46]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[21], [2], [46]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[21], [2], [46]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[21], [2], [46]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[21], [2], [46]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[21], [2], [46]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[21], [2], [46]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[21], [2], [46]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[21], [2], [46]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[21], [2], [46]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[21], [2], [46]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[21], [2], [46]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[21], [2], [46]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[21], [2], [46]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[21], [2], [46]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[21], [2], [46]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[21], [2], [46]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[21], [2], [46]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[21], [2], [46]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[21], [2], [46]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[21], [2], [46]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[21], [2], [46]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[21], [2], [46]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[21], [2], [46]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[64]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[21], [2], [46]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[21], [2], [46]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[21], [2], [46]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[21], [2], [46]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[21], [2], [46]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[21], [2], [46]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[21], [2], [46]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[21], [2], [46]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[21], [2], [46]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[21], [2], [46]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[21], [2], [46]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[21], [2], [46]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[21], [2], [46]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[21], [2], [46]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[21], [2], [46]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[21], [2], [46]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[21], [2], [46]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[21], [2], [46]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[21], [2], [46]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[21], [2], [46]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[21], [2], [46]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[21], [2], [46]
	Transporter induction					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[21], [2], [46], [47]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[21], [2], [46], [47]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[21], [2], [46], [47]
Affected intra/extra-hepatic metabolism
	UGT inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[21], [2], [46]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[21], [2], [46]
	CYP450 enzyme induction					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[21], [2], [46], [47]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[21], [2], [46], [47]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[21], [2], [46], [47]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[21], [2], [46], [47]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[21], [2], [46], [47]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[21], [2], [46], [47]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[21], [2], [46], [47]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[21], [2], [46], [47]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[21], [2], [46], [47]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[21], [2], [46], [47]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[2], [46], [47]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[21], [2], [46], [47]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[21], [2], [46], [47]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
	Increased risk of bleeding					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2], [3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[2], [4], [5]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[4]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[7]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[8]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[4], [9]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[10]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[11]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[12], [13], [2], [14]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[4], [20]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[21], [2], [22]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[23]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[24]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[2], [25], [26]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[43]
D1613		Tositumomab	NA	NA	Major		Inter Info	[44], [45]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[44], [45]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[15], [16], [17]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[18]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[19]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[15], [16], [17]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[48]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[21], [2], [49], [50], [51]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[52]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[2], [53]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[54], [55]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[21], [2], [56]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[57]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[58], [59], [60], [61]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[58], [59], [60], [61]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[2], [62]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[63]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[58], [59], [60], [61]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[65], [66]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [67]

References
1	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
4	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
5	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
6	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
7	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
8	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
9	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
10	Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
11	Product Information. In-111 Zevalin (ibritumomab). IDEC Pharmaceuticals Corporation, San Diego, CA.
12	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
13	Cerner Multum, Inc. "Canadian Product Information.".
14	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
15	Canadian Pharmacists Association.
16	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
17	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
18	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
19	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
20	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
21	Cerner Multum, Inc. "Australian Product Information.".
22	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
23	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
24	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
25	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
26	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
27	Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
28	Bennett CL, Schumock GT, Desai AA, et al "Thalidomide-associated deep vein thrombosis and pulmonary embolism." Am J Med 113 (2002): 603-6. [PMID: 12459408]
29	Cavo M, Zamagni E, Cellini C, et al. "Deep-vein thrombosis in patients with multiple myeloma receiving first-line thalidomide-dexamethasone therapy." Blood 100 (2002): 2272-3. [PMID: 12229885]
30	Escudier B, Lassau N, Leborgne S, Angevin E, Laplanche A "Thalidomide and venous thrombosis." Ann Intern Med 136 (2002): 711. [PMID: 11992318]
31	Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]
32	Fine HA, Wen PY, Maher EA, et al. "Phase II Trial of Thalidomide and Carmustine for Patients With Recurrent High-Grade Gliomas." J Clin Oncol 21 (2003): 2299-304. [PMID: 12805330]
33	Lee CK, Barlogie B, Munshi N, et al "DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma." J Clin Oncol 21 (2003): 2732-9. [PMID: 12860952]
34	Osman K, Comenzo R, Rajkumar SV "Deep venous thrombosis and thalidomide therapy for multiple myeloma." N Engl J Med 344 (2001): 1951-2. [PMID: 11419443]
35	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
36	Rajkumar SV, Hayman S, Gertz MA, et al. "Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma." J Clin Oncol 20 (2002): 4319-23. [PMID: 12409330]
37	Urbauer E, Kaufmann H, Nosslinger T, Raderer M, Drach J "Thromboembolic events during treatment with thalidomide." Blood 99 (2002): 4247-8. [PMID: 12043695]
38	Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R "Thalidomide alone or with dexamethasone for previously untreated multiple myeloma." J Clin Oncol 21 (2003): 16-9. [PMID: 12506164]
39	Zangari M, Anaissie E, Barlogie B, et al "Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy." Blood 98 (2001): 1614-5. [PMID: 11520815]
40	Zangari M, Barlogie B, Anaissie E, et al "Deep vein thrombosis in patients with mutiple myeloma treated with thalidomide and chemotherapy: effects of prophylactic and therapeutic anticoagulation." Br J Haematol 126 (2004): 715-21. [PMID: 15327525]
41	Zangari M, Siegel E, Barlogie B, et al "Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy." Blood 100 (2002): 1168-71. [PMID: 12149193]
42	Desai AA, Vogelzang NJ, Rini BI, Ansari R, Krauss S, Stadler WM "A high rate of venous thromboembolism in a multi-institutional Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma." Cancer 95 (2002): 1629-36. [PMID: 12365009]
43	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
44	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
45	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
46	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
47	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
48	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
49	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
50	Gilead Sciences, Inc "About Remdesivir.".
51	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
52	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
53	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
54	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
55	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
56	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
57	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
58	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
59	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
60	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
61	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
62	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
63	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
64	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
65	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
66	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
67	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence