Details of Drug

Details of Drug

 Drug General Information (ID: D0181)
  Drug Name
Bictegravir
  Drug Type Small molecule
  Drug Synonymous
Bictegravir; 1611493-60-7; GS-9883; GS-9883-01; UNII-8GB79LOJ07; (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide; 8GB79LOJ07; (1S,11R,13R)-5-hydroxy-3,6-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-diene-7-carboxamide; Bictegravir [INN]; Bictegravir [USAN:INN]; bictegravirum; GS 9883; Bictegravir (USAN/INN); CHEMBL3989866; SCHEMBL15914278; GTPL11575; CHEBI:172943; BDBM330048; AMY12383; BCP25703; EX-A3161; GS9883; s5911; DB11799; DT-0020; 2,5-Methanopyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazepine-10-carboxamide, 2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-((2,4,6-trifluorophenyl)methyl)-, (2R,5S,13aR)-; AC-30658; HY-17605; CS-0014685; D10909; N16998; US9663528, 42; A902376; Q27270406; GS-9883; GS 9883; GS9883; GS-9883-01; (1S,11R,13R)-5-hydroxy-3,6-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-12-oxa-2,9-diazatetracyclo[11.2.1.0(2),(1)(1).0?,?]hexadeca-4,7-diene-7-carboxamide; (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2, 1-b][1,3]oxazepine-10-carboxamide
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  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C21H18F3N3O5
  InChI InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10-,11+,16+/m0/s1
  InChIKey SOLUWJRYJLAZCX-LYOVBCGYSA-N
  Canonical SMILES C1C[C@@H]2C[C@H]1N3[C@H](O2)CN4C=C(C(=O)C(=C4C3=O)O)C(=O)NCC5=C(C=C(C=C5F)F)F
  External Link
Pubchem ID 90311989
INTEDE ID DR0212

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
BM003  Complex formation
BM010  Transporter inhibition
BM017  CYP450 enzyme inhibition
BM019  UGT inhibition
BM022  CYP450 enzyme induction
  Relation Graph
 Full list of drugs interacting with Bictegravir
      Affected gastrointestinal absorption
   Complex formation Drug Num:  27
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Major    Inter Info   
[1], [2], [3]
D0125
 
Attapulgite
 
Al2H29Mg2O15Si4-
 
56842194 
Major    Inter Info   
[1], [2], [3]
D0239
 
Calcium glubionate anhydrous
 
C18H32CaO19
 
64776 
Major    Inter Info   
[1], [2], [3]
D0243
 
Calcium lactate
 
C6H10CaO6
 
13144 
Major    Inter Info   
[1], [2], [3]
D0649
 
Ferrous fumarate
 
C4H2FeO4
 
6433164 
Major    Inter Info   
[1], [2], [3]
D0650
 
Ferrous gluconate
 
C12H22FeO14
 
23616740 
Major    Inter Info   
[1], [2], [3]
D0651
 
Ferrous sulfate anhydrous
 
FeO4S
 
24393 
Major    Inter Info   
[1], [2], [3]
D0971
 
Magnesium gluconate
 
C12H22MgO14
 
11418570 
Major    Inter Info   
[1], [2], [3]
D1566
 
Tetraferric tricitrate decahydrate
 
C18H32Fe4O31
 
90478690 
Major    Inter Info   
[1], [2], [3]
D0235
 
Calcium acetate
 
C4H6CaO4
 
6116 
Major    Inter Info   
[1], [2], [3]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Major    Inter Info   
[1], [2], [3]
D0238
 
Calcium citrate
 
C12H10Ca3O14
 
13136 
Major    Inter Info   
[1], [2], [3]
D0241
 
Calcium gluconate
 
C12H22CaO14
 
9290 
Major    Inter Info   
[1], [2], [3]
D0242
 
Calcium glycerophosphate
 
C3H7CaO6P
 
120096 
Major    Inter Info   
[1], [2], [3]
D0244
 
Calcium Phosphate
 
Ca3O8P2
 
24456 
Major    Inter Info   
[1], [2], [3]
D0847
 
Iron
 
Fe
 
23925 
Major    Inter Info   
[1], [2], [3]
D0849
 
Iron protein succinylate
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D0877
 
Kaolin
 
Al2H4O9Si2
 
56841936 
Major    Inter Info   
[1], [2], [3]
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Major    Inter Info   
[1], [2], [3]
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Major    Inter Info   
[1], [2], [3]
D0969
 
Magnesium chloride
 
Cl2H12MgO6
 
643991 
Major    Inter Info   
[1], [2], [3]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Major    Inter Info   
[1], [2], [3]
D0972
 
Magnesium glycinate
 
C4H8MgN2O4
 
84645 
Major    Inter Info   
[1], [2], [3]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Major    Inter Info   
[1], [2], [3]
D0974
 
Magnesium oxide
 
MgO
 
14792 
Major    Inter Info   
[1], [2], [3]
D0975
 
Magnesium sulfate
 
MgO4S
 
24083 
Major    Inter Info   
[1], [2], [3]
D1511
 
Sucralfate
 
C12H54Al9O55S8
 
121494085 
Major    Inter Info   
[1], [2], [3]
      Affected cellular transport
   Transporter inhibition Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[3], [5], [6]
D0568
 
Enasidenib
 
C19H17F6N7O
 
89683805 
Moderate    Inter Info   
[1], [8], [9]
D1539
 
Tedizolid
 
C17H15FN6O3
 
11234049 
Moderate    Inter Info   
[2], [15], [16]
D0408
 
Daclatasvir
 
C40H50N8O6
 
25154714 
Moderate    Inter Info   
[2], [17]
D0412
 
Dalfampridine
 
C5H6N2
 
1727 
Moderate    Inter Info   
[1], [2], [18]
D0561
 
Eltrombopag
 
C25H22N4O4
 
135449332 
Moderate    Inter Info   
[19], [20], [21]
D0745
 
Guanfacine
 
C9H9Cl2N3O
 
3519 
Moderate    Inter Info   
[1], [2], [3]
D1423
 
Rolapitant
 
C25H26F6N2O2
 
10311306 
Moderate    Inter Info   
[26]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Moderate    Inter Info   
[1], [2], [18]
D1919
 
Varenicline
 
C13H13N3
 
170361 
Moderate    Inter Info   
[1], [2], [3]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  42
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Moderate    Inter Info   
[1], [2], [3]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[7]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[1], [2], [3]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[10], [11], [12]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[13]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[14], [12]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Moderate    Inter Info   
[1], [2], [3]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Moderate    Inter Info   
[1], [2], [3]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Moderate    Inter Info   
[1], [2], [3]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[1], [2], [3]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[1], [2], [3]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[1], [2], [3]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Moderate    Inter Info   
[1], [2], [3]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Moderate    Inter Info   
[1], [2], [3]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[1], [2], [3]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Moderate    Inter Info   
[1], [2], [3]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Moderate    Inter Info   
[1], [2], [3]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[1], [2], [3]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[1], [2], [3]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[1], [2], [3]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Moderate    Inter Info   
[1], [2], [3]
D0715
 
Gemfibrozil
 
C15H22O3
 
3463 
Moderate    Inter Info   
[1], [2], [3]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[1], [2], [3]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Moderate    Inter Info   
[1], [2], [3]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Moderate    Inter Info   
[1], [2], [3]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[22], [23], [24]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[1], [2], [3]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Moderate    Inter Info   
[1], [2], [3]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[1], [2], [3]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Moderate    Inter Info   
[1], [2], [3]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Moderate    Inter Info   
[1], [2], [3]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[1], [2], [25]
D1214
 
Palbociclib
 
C24H29N7O2
 
5330286 
Moderate    Inter Info   
[1], [2], [3]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[1], [2], [3]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Moderate    Inter Info   
[1], [2], [3]
D1387
 
Regorafenib
 
C21H15ClF4N4O3
 
11167602 
Moderate    Inter Info   
[1], [2], [3]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[1], [2], [3]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Moderate    Inter Info   
[1], [2], [3]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Moderate    Inter Info   
[1], [2], [3]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[1], [2], [3]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[1], [2], [3]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Moderate    Inter Info   
[1], [2], [3]
   CYP450 enzyme induction Drug Num:  41
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[2], [3], [4]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[2], [3], [4]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Major    Inter Info   
[2], [3], [4]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Major    Inter Info   
[2], [3], [4]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Major    Inter Info   
[2], [3], [4]
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[2], [3], [6]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[2], [3], [6]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Moderate    Inter Info   
[2], [3], [6]
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Moderate    Inter Info   
[2], [3], [6]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[2], [3], [6]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[2], [3], [6]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[2], [3], [6]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[2], [3], [6]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[2], [3], [6]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[2], [3], [6]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[2], [3], [6]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[2], [3], [6]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[2], [3], [6]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[2], [3], [6]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[2], [3], [6]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[2], [3], [6]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[2], [3], [6]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[2], [3], [6]
D0732
 
Glycerol phenylbutyrate
 
C33H38O6
 
10482134 
Moderate    Inter Info   
[2], [3], [6]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[2], [3], [6]
D0905
 
Lesinurad
 
C17H14BrN3O2S
 
53465279 
Moderate    Inter Info   
[2], [3], [6]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[2], [3], [6]
D1050
 
Metreleptin
 
NA
 
NA
Moderate    Inter Info   
[2], [3], [6]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[2], [3], [6]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[2], [3], [6]
D1186
 
Oritavancin
 
C86H97Cl3N10O26
 
16136912 
Moderate    Inter Info   
[2], [3], [6]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[2], [3], [6]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[2], [3], [6]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Moderate    Inter Info   
[2], [3], [6]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Moderate    Inter Info   
[2], [3], [6]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[2], [3], [6]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[2], [3], [6]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[2], [3], [6]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[2], [3], [6]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[2], [3], [6]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[2], [3], [6]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
4 Product Information. Descovy (emtricitabine-tenofovir). Gilead Sciences, Foster City, CA.
5 Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
6 Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
7 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
8 Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
9 Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
10 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
11 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
12 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
13 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
14 Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
15 Product Information. Sivextro (tedizolid). Cubist Pharmaceuticals Inc, Lexington, MA.
16 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
17 Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
18 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
19 Allred AJ, Bowen CJ, Park JW, et al. "Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers." Br J Clin Pharmacol 72 (2011): 321-9. [PMID: 21434975]
20 Canadian Pharmacists Association.
21 Kalliokoski A, Niemi M "Impact of OATP transporters on pharmacokinetics." Br J Pharmacol 158 (2009): 693-705. [PMID: 19785645]
22 Lilja JJ, Kivisto KT, Neuvonen PJ "Grapefruit juice-simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors." Clin Pharmacol Ther 64 (1998): 477-83. [PMID: 9834039]
23 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
24 Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]
25 Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
26 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.