Details of Drug

Drug General Information (ID: D0149)
Drug Name	Bedaquiline
Drug Type	Small molecule
Drug Synonymous	SIRTURO (TN) Click to Show/Hide
Disease Class	MG50-MG52: Antimicrobial drug resistance
Therapeutic Class	Antituberculosis Agents
Structure
Structure	3D Structure		2D Structure
Formula	C32H31BrN2O2
InChI	1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1
InChIKey	QUIJNHUBAXPXFS-XLJNKUFUSA-N
Canonical SMILES	CN(C)CCC(C1=CC=CC2=CC=CC=C21)(C(C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O
External Link
	Pubchem ID	5388906
	CAS Number	843663-66-1
	CHEBI ID	72292
	TTD ID	D0Y4QG

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid
Relation Graph

Full list of drugs interacting with Bedaquiline
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[185]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[3], [190]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[172]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[1]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[197]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[3], [1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[3], [1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[3], [1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[3], [1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[3], [30], [1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[3], [1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[3], [1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[3], [1]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[3], [1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[3], [1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[3], [1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[3], [1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[3], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[3], [1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[3], [1]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[3], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[3], [1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[3], [1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[3], [1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[3], [1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[3], [30], [1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[3], [1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[11], [189]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[196]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[216], [217], [218], [219], [220]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 201
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[34]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[10], [116], [117]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[119]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[123]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[10], [116], [117]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[1]
D0018		Acitretin	C21H26O3	5284513	Moderate		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[1]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[1]
D0065		Aminosalicylic acid	C7H7NO3	4649	Moderate		Inter Info	[1]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[1]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[1]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[1]
D0121		Atovaquone	C22H19ClO3	74989	Moderate		Inter Info	[1]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[1]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[1]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[1]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[1]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[1]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[1]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[1]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[1]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[1]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[191]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[1]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[1]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[1]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[1]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[1]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[1]
D1180		Onasemnogene abeparvovec	NA	NA	Moderate		Inter Info	[1]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[1]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[1]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[1]
D1327		Prasterone enantate	C26H40O3	163331	Moderate		Inter Info	[192], [1]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[11], [3], [193], [194], [195]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[1]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[1]
D1531		Tagraxofusp	NA	NA	Moderate		Inter Info	[1]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[1]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[1]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[192], [1]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[1]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[1]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[1]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[1]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[1]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[1]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[1]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[1]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Moderate		Inter Info	[1]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[1]
D0350		Clavulanic acid	C8H9NO5	5280980	Moderate		Inter Info	[192], [1]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[1]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[1]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[192], [1]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[1]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[1]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[1]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[1]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[1]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[1]
D0566		Emtricitabine	C8H10FN3O3S	60877	Moderate		Inter Info	[1]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[1]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[1]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[1]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[1]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[1]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[1]
D0637		Febuxostat	C16H16N2O3S	134018	Moderate		Inter Info	[1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[1]
D0677		Fluoxymesterone	C20H29FO3	6446	Moderate		Inter Info	[1]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[1]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[1]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[1]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[1]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[192], [1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[1]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[1]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[192], [1]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[1]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[1]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[1]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[1]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[1]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[1]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[1]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[1]
D0889		Lamivudine	C8H11N3O3S	60825	Moderate		Inter Info	[1]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[1]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[1]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[1]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[1]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[192], [1]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[1]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[1]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[1]
D1021		Methimazole	C4H6N2S	1349907	Moderate		Inter Info	[1]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[1]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[1]
D1042		Methyltestosterone	C20H30O2	6010	Moderate		Inter Info	[1]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[1]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[1]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[1]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[1]
D1111		Natalizumab	NA	NA	Moderate		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[1]
D1132		Nicotinamide	C6H6N2O	936	Moderate		Inter Info	[192], [1]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[1]
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[1]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[1]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[1]
D1207		Oxymetholone	C21H32O3	5281034	Moderate		Inter Info	[1]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[1]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[1]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[1]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[1]
D1243		Pemoline	C9H8N2O2	4723	Moderate		Inter Info	[1]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[1]
D1261		Phenazopyridine	C11H11N5	4756	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[1]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[1]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[1]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[1]
D1359		Propylthiouracil	C7H10N2OS	657298	Moderate		Inter Info	[1]
D1364		Pyrazinamide	C5H5N3O	1046	Moderate		Inter Info	[1]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[1]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[1]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[1]
D1405		Riluzole	C8H5F3N2OS	5070	Moderate		Inter Info	[1]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[1]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[1]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[1]
D1503		Stanozolol	C21H32N2O	25249	Moderate		Inter Info	[1]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[1]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[1]
D1514		Sulfadoxine	C12H14N4O4S	17134	Moderate		Inter Info	[1]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[1]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[1]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[1]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[1]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[1]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[1]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[1]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[1]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[192], [1]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[1]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[1]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[192], [1]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[1]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[1]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[1]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[1]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[192], [1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[1]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[1]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[1]
	Increased risk of prolong QT interval					Drug Num: 169
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[10], [11], [3], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[10], [11], [3], [23]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[1]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[28]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[29]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[31]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[32]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[42], [3], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[10], [11], [3], [61], [62], [21], [63]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[10], [11], [3], [64], [21]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[10], [11], [3], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[10], [11], [3], [65]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[10], [11], [3], [66]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[10], [11], [3], [67], [68], [21]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[10], [69], [11], [3], [70], [71], [21]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[73], [74], [75], [10], [11], [3], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[74], [10], [11], [3], [96], [97], [98]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[99], [10], [11], [3], [100], [101], [102], [103], [104]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[10], [11], [3], [105], [106], [107], [108], [109], [110], [21]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[42], [3], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[10], [11], [3], [111]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[10], [11], [3], [112], [21]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [118], [21]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1]
D0948		Lopinavir	C37H48N4O5	92727	Major		Inter Info	[1]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[11], [3], [120]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[10], [11], [3], [121], [21]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[10], [11], [3], [122]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[73], [74], [75], [10], [11], [3], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[10], [11], [3], [124]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[125]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[126], [127], [128], [129], [130], [131], [132], [133]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[10], [11], [3], [134]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[135], [136]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [67], [137], [21]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[10], [11], [3], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[10], [11], [3], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[1]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[10], [11], [3], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[74], [10], [11], [3], [162], [163], [78], [80], [82], [164], [83], [84], [165], [86], [87], [88], [89], [166], [93], [98], [167]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[10], [11], [3], [168], [67], [169], [170], [171], [21]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[10], [11], [3], [172]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[10], [11], [3], [173]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[10], [11], [3], [174]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[10], [11], [3], [67], [175], [21]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[11], [3], [179], [180], [181], [182], [183], [184]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[11], [3], [201]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[202], [203]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[11], [3], [204]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[11], [221], [222], [223]
D1645		Trimethoprim	C14H18N4O3	5578	Minor		Inter Info	[10], [11], [3], [224], [225], [226], [227]
	Increased risk of ventricular arrhythmias					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[22]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[24], [25]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [26], [27]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[33]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Major		Inter Info	[35], [36], [37]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Major		Inter Info	[35], [36], [37]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[11], [38]
D1488		Sodium sulfate	Na2O4S	24436	Major		Inter Info	[35], [36], [37]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[10], [11], [3], [72], [63]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[113], [114], [115]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[113], [114], [115]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[113], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [114], [156], [157], [158], [159], [115], [160], [161]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[113], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [114], [156], [157], [158], [159], [115], [160], [161]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[113], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [176], [177], [150], [151], [152], [153], [154], [178], [155], [114], [156], [157], [158], [159], [115], [160], [161]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[11], [3], [188]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[176], [156], [159]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[113], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [176], [177], [150], [151], [152], [153], [154], [178], [155], [114], [156], [157], [158], [159], [115], [160], [161]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[11], [3], [188]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[176], [156], [159]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[10], [11], [3], [198], [199], [200]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[113], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [176], [177], [150], [151], [152], [153], [154], [178], [155], [114], [156], [157], [158], [159], [115], [160], [161]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[10], [11], [3], [198], [199], [200]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[113], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [176], [177], [150], [151], [152], [153], [154], [178], [155], [114], [156], [157], [158], [159], [115], [160], [161]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[10], [11], [3], [186], [187], [188]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[10], [11], [3], [198], [199], [200]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[142], [148], [153]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[113], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [176], [177], [150], [151], [152], [153], [154], [178], [155], [114], [156], [157], [158], [159], [115], [160], [161]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[11], [3], [215]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[3], [39], [40]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[41]

References
1	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
2	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
5	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
6	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
7	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
8	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
9	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
10	Canadian Pharmacists Association.
11	Cerner Multum, Inc. "Australian Product Information.".
12	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
13	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
14	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
15	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
16	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
17	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
18	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
19	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
20	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
21	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
22	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
23	Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
24	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
25	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
26	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
27	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
28	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
29	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
30	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
31	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
32	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
33	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
34	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
35	Hill AG, Parry BR "Hypokalaemia following bowel cleansing with sodium phosphate." N Z Med J 109 (1996): 347. [PMID: 8862361]
36	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
37	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
38	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
39	UK government "Typhoid.".
40	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
41	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
42	Harper KM, Knapp DJ, Criswell HE, Breese GR "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl) 235 (2018): 3363-79. [PMID: 32936259]
43	Javelot H, El-Hage W, Meyer G, Becker G, Michel B, Hingray C "COVID-19 and (hydroxy)chloroquine-azithromycin combination: should we take the risk for our patients?" Br J Clin Pharmacol Apr 29 (2020): epub ahead of print. [PMID: 32350872]
44	National Institutes of Health (NIH) "Coronavirus Disease 2019 (COVID-19) Treatment Guidelines.".
45	Product Information. Chloroquine Phosphate (chloroquine). West-Ward Pharmaceutical Corporation, Eatontown, NJ.
46	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
47	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
48	Roden DM, Harrington RA, Poppas A, Russo AM "Considerations for drug interactions on QTc in exploratory COVID-19 (Coroanvirus disease 2019) treatment." Heart Rhythm Apr 14 (2020): epub ahead of print. [PMID: 32302703]
49	Sacher F, Fauchier L, Boveda S, et.al "Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection." Arch Cardiovasc Dis Apr 24 (2020): epub ahead of print. [PMID: 32354666]
50	Saleh M, Gabriels J, ChangD, et.al "The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection." Circ Arrhythm Electrophysiol Apr 29 (2020): epub ahead of print. [PMID: 32347743]
51	Sapp JL, Alqarawi W, MacIntyre CJ, et.al "Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: A statement from the Canadian Heart Rhythm Society." Can J Cardiol Apr 8 (2020): epub ahead of print. [PMID: 32299753]
52	Smit C, Peeters MYM, van den Anker JN, Knibbe CAJ "Chloroquine for SARS-CoV-2: Implications of its unique pharmacokinetic and safety properties." Clin Pharmacokinet Ar 18 (2020): epub ahead of print. [PMID: 32306288]
53	Bessiere F, Roccia H, Deliniere A, et.al "Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit." JAMA Cardiol May 1 (2020): epub ahead of print. [PMID: 32936266]
54	Borba MGS, Val FFA, Sampaio VS, et.al "Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 1 (SARS-CoV-2) infection: A randomized clinical trial." JAMA Netw Open Apr 1 (2020): epub ahead of print. [PMID: 32330277]
55	Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ "Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19)" Mayo Clin Proc Apr 7 (2020): epub ahead of print. [PMID: 32359771]
56	Kapoor A, Pandurangi U, Arora V, et.al "Cardiovascular risks of hydroxychloroquine in treatment and prophylaxis of COVID-19 patients: A scientific statement from the Indian Heart Rhythm Society." Indian Pacing Electorphysiol J Apr 8 (2020): epub ahead of print. [PMID: 32278018]
57	Mercuro NJ, Yen CF, Shim DJ, et.al "Risk of QT interval prolongation associated with the use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)" JAMA Cardiol May 1:e201834 (2020): epub ahead of print. [PMID: 32936252]
58	mitra RL, Greenstein SA, Epstein lm "An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin Possible benefits of intravenous lidocaine." HeartRythm Case Rep Apr 1 (2020): epub ahead of print. [PMID: 32363145]
59	US Food and Drug Administration "FACT SHEET FOR HEALTH CARE PROVIDERS EMERGENCY USE AUTHORIZATION (EUA) OF CHLOROQUINE PHOSPHATE SUPPLIED FROM THE STRATEGIC NATIONAL STOCKPILE FOR TREATMENT OF COVID-19 IN CERTAIN HOSPITALIZED PATIENTS. Available from: URL: https://www.fda.gov/media/13653" ([2020, Apr 27]):.
60	US Food and Drug Administration "Hydroxychloroquine or Chloroquine for COVID-19: Drug Safety Communication - FDA Cautions Against Use Outside of the Hospital Setting or a Clinical Trial Due to Risk of Heart Rhythm Problems.".
61	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
62	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
63	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
64	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
65	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
66	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
67	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
68	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
69	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
70	Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
71	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
72	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
73	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
74	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
75	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
76	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
77	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
78	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
79	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
80	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
81	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
82	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
83	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
84	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
85	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
86	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
87	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
88	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
89	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
90	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
91	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
92	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
93	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
94	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
95	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
96	Lode H, Vogel F, Elies W "Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance." Clin Ther 21 (1999): 61-74. [PMID: 10090425]
97	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
98	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
99	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
100	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
101	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
102	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
103	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
104	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]
105	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
106	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
107	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
108	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
109	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
110	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
111	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
112	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
113	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
114	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
115	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
116	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
117	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
118	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
119	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
120	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
121	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
122	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
123	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
124	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
125	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
126	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
127	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
128	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
129	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
130	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
131	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
132	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
133	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
134	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
135	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
136	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
137	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
138	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
139	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
140	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
141	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
142	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
143	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
144	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
145	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
146	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
147	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
148	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
149	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
150	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
151	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
152	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
153	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
154	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
155	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
156	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
157	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
158	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
159	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
160	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
161	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
162	Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
163	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
164	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
165	Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
166	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
167	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
168	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
169	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
170	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
171	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
172	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
173	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
174	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
175	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
176	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
177	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
178	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
179	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
180	Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
181	Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
182	Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
183	Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
184	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
185	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
186	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
187	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
188	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
189	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
190	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
191	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
192	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
193	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
194	Gilead Sciences, Inc "About Remdesivir.".
195	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
196	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
197	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
198	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
199	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
200	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
201	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
202	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
203	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
204	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
205	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
206	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
207	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
208	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
209	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
210	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
211	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
212	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
213	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
214	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
215	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
216	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
217	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
218	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
219	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
220	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
221	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
222	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
223	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
224	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
225	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
226	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
227	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]

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