Details of Drug

Details of Drug

 Drug General Information (ID: D0124)
  Drug Name
Atropine (ophthalmic)
  Drug Type Small molecule
  Drug Synonymous
dl-Hyoscyamine; Atropin; Atropen; dl-Tropyltropate; Atropinol; Atropina; Eyesules; Troyl tropate; Isopto-atropine; Atropin [German]; Atropina [Italian]; Atropin-flexiolen; (+,-)-Tropyl tropate; 51-55-8; DL-Tropyl tropate; Tropine, tropate (ester); Tropic acid, ester with tropine; Atropine sulfate; CCRIS 3080; Atropine (USP); Isopto Atropine; Tropic acid, 3-alpha-tropanyl ester; Atropt; HSDB 2199; DL-Tropanyl; Anaspaz; Atropair; Atrosulf; Belladenal; Cytospaz; Minims; Tropanol; Urised; Atropine Care; Atropine [BAN]; Atropinium cation; Hyoscyamine sulfate; Minims Atropine; OR22908; Atropen (TN); Bellergal-S; D1-hyoscyamine; Dl-Hyoscyamine; Dl-Tropyltropate; I-Tropine; NP-010662; Neo-Diophen; Ocu-Tropine; Protamine & Atropine; Atropinium(1+); Tropan-3alpha-ol; Tropan-3beta-ol; Atropine Sulfate SOP; DL-Tropanyl 2-hydroxy-1-phenylpropionate; Beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; Beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; Tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; Endo-8-methyl-8-azabicyclo[321]octan-3-ol; B eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[321]oct-3-yl ester; [(1R,5S)-8-methyl-8-azabicyclo[321]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[321]oct-3-yl] 3-hydroxy-2-phenyl-propanoate; Endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[321]oct-3-yl ester; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(321)oct-3-yl ester; (3-endo)-8-methyl-8-azabicyclo[321]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[321]oct-3-yl 3-hydroxy-2-phenylpropanoate; (3-endo)-8-methyl-8-azabicyclo[321]oct-3-yl tropate; (3-endo)-8-methyl-8-azabicyclo[321]octan-3-ol; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[321]octane; (3-exo)-8-methyl-8-azabicyclo[321]octan-3-ol; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester); 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); 1alphaH,5alphaH-Tropan-3alpha-ol; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); 1alphaH,5alphaH-Tropan-3beta-ol; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; 8-Methyl-8-azabicyclo[321]oct-3-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[321]oct-3-yl tropate; 8-Methyl-8-azabicyclo[321]octan-3-yl 3-hydroxy-2-phenylpropionate
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  Disease Class NE6Z: Unspecific substance harmful effect
  Therapeutic Class Antiarrhythmic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C17H23NO3
  InChI 1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
  InChIKey RKUNBYITZUJHSG-PJPHBNEVSA-N
  Canonical SMILES CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
  External Link
Pubchem ID 174174
CAS Number 51-55-8
CHEBI ID 16684
TTD ID D0RG3O
VARIDT ID DR00665

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM041  Additive hypertensive effects
BM091  Antagonize the effect of cholinergic agents
  Relation Graph
 Full list of drugs interacting with Atropine (ophthalmic)
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1276
 
Phenylephrine
 
C9H13NO2
 
6041 
Moderate    Inter Info   
[8], [9], [10]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of cholinergic agents Drug Num:  15
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0015
 
Acetylcholine
 
C7H16NO2+
 
187 
Moderate    Inter Info   
[1], [2]
D0175
 
Bethanechol
 
C7H17N2O2+
 
2370 
Moderate    Inter Info   
[3], [4]
D0440
 
Demecarium (ophthalmic)
 
C32H52N4O4+2
 
5966 
Moderate    Inter Info   
[1], [2]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Moderate    Inter Info   
[5], [6], [7]
D0546
 
Echothiophate (ophthalmic)
 
C9H23NO3PS+
 
10548 
Moderate    Inter Info   
[1], [2]
D0707
 
Galantamine
 
C17H21NO3
 
9651 
Moderate    Inter Info   
[5], [6], [7]
D0856
 
Isoflurophate (ophthalmic)
 
C6H14FO3P
 
5936 
Moderate    Inter Info   
[1], [2]
D1285
 
Physostigmine
 
C15H21N3O2
 
5983 
Moderate    Inter Info   
[5], [6], [7]
D1286
 
Physostigmine (ophthalmic)
 
C15H21N3O2
 
5983 
Moderate    Inter Info   
[1], [2]
D1288
 
Pilocarpine
 
C11H16N2O2
 
5910 
Moderate    Inter Info   
[3], [4]
D1289
 
Pilocarpine (ophthalmic)
 
C11H16N2O2
 
5910 
Moderate    Inter Info   
[1], [2]
D1418
 
Rivastigmine
 
C14H22N2O2
 
77991 
Moderate    Inter Info   
[5], [6], [7]
D0256
 
Carbamoylcholine (ophthalmic)
 
C6H15N2O2+
 
2551 
Moderate    Inter Info   
[1], [2]
D0308
 
Cevimeline
 
C10H17NOS
 
83898 
Moderate    Inter Info   
[3], [4]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[5], [6], [7]
References
1 Multum Information Services, Inc. Expert Review Panel.
2 Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
3 Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
4 Product Information. Salagen Tablets (pilocarpine). Boehringer-Ingelheim, Ridgefield, CT.
5 Katz IR, Sands LP, Bilker W, DiFilippo S, Boyce A, D'Angelo K "Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride." J Am Geriatr Soc 46 (1998): 8-13. [PMID: 9434659]
6 Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
7 Roe CM, Anderson MJ, Spivack B "Use of anticholinergic medications by older adults with dementia." J Am Geriatr Soc 50 (2002): 836-42. [PMID: 12028169]
8 Levine MA, Leenen FH "Role of vagal activity in the cardiovascular responses to phenylephrine in man." Br J Clin Pharmacol 33 (1992): 333-6
9 Daelman F, Andrejak M, Rajaonarivony D, Bryselbout E, Jezraoui P, Ossart M "Phenylephrine eyedrops, systemic atropine and cardiovascular adverse events." Therapie 49 (1994): 467
10 Lai YK "Adverse effect of intraoperative phenylephrine 10%: case report." Br J Ophthalmol 73 (1989): 468-9