Details of Drug

Drug General Information (ID: D0106)
Drug Name	Armodafinil
Drug Type	Small molecule
Drug Synonymous	Nuvigil; 112111-43-0; (R)-Modafinil; (R)-(-)-Modafinil; CEP-10953; UNII-V63XWA605I; CRL 40982; CEP 10953; V63XWA605I; CHEMBL1201192; CHEBI:77590; 2-[(R)-(Diphenylmethyl)sulfinyl]acetamide; (-)-2-((R)-(Diphenylmethyl)sulfinyl)acetamide; (-)-2-[(r)-(diphenylmethyl)sulfinyl]acetamide; Armodafinil [USAN:INN]; armodafinilo; armodafinilum; l-Modafinil; Nuvigil (TN); (-)-(R)-modafinil; Armodafinil (USAN/INN); SCHEMBL34489; ZINC6156; ACE037; Armodafinil, > YFGHCGITMMYXAQ-LJQANCHMSA-N Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Cns Stimulants
Structure
Structure	3D Structure		2D Structure
Formula	C15H15NO2S
InChI	1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1
InChIKey	YFGHCGITMMYXAQ-LJQANCHMSA-N
Canonical SMILES	C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
External Link
	Pubchem ID	9690109
	CAS Number	112111-43-0
	CHEBI ID	77590
	TTD ID	D0J5RN
	INTEDE ID	DR0137
	VARIDT ID	DR00998

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM041 Additive hypertensive effects BM078 Increased risk of rapid heart rate
Relation Graph

Full list of drugs interacting with Armodafinil
Affected cellular transport
	Transporter inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[61]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[81]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[90]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[91]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[95]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 74
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[13], [14], [15]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[4], [36], [34], [35], [37]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[4], [36], [34], [35], [37]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[4], [34], [35], [42], [37], [43]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[47]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[4], [134], [34], [35], [37]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[135], [136], [137], [138], [139], [140], [141], [142], [143]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[144]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[4], [36], [34], [35], [37]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[4], [134], [34], [35], [37]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[4], [36], [34], [35], [37]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[4], [134], [34], [35], [37]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[34], [42], [37]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[4], [36], [34], [35], [37]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[4], [34], [37]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[8], [4], [6], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[4], [134], [34], [35], [37]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [134], [34], [35], [37]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[4], [36], [34], [35], [37]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[204]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[4], [134], [34], [35], [37]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[4], [36], [34], [35], [37]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[4], [134], [34], [35], [37]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[4], [134], [34], [35], [37]
D1350		Proguanil	C11H16ClN5	6178111	Moderate		Inter Info	[4], [134], [34], [35], [37]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [134], [34], [35], [37]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[4], [36], [34], [35], [37]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[4], [134], [34], [35], [37]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[4], [36], [34], [35], [37]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[4], [34], [35], [42], [37], [43]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[4], [34], [35]
D0100		Aprepitant	C23H21F7N4O3	135413536	Minor		Inter Info	[4], [34], [35]
D0192		Boceprevir	C27H45N5O5	10324367	Minor		Inter Info	[4], [34], [35]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Minor		Inter Info	[4], [34], [35]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Minor		Inter Info	[4], [34], [35]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[4], [34], [35]
D0735		Goldenseal	NA	NA	Minor		Inter Info	[4], [34], [35]
D0789		Idelalisib	C22H18FN7O	11625818	Minor		Inter Info	[4], [34], [35]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Minor		Inter Info	[4], [34], [35]
D0869		Ivacaftor	C24H28N2O3	16220172	Minor		Inter Info	[4], [34], [35]
D0906		Letermovir	C29H28F4N4O4	45138674	Minor		Inter Info	[4], [34], [35]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[4], [34], [35]
D1232		Pazopanib	C21H23N7O2S	10113978	Minor		Inter Info	[4], [34], [35]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[4], [34], [35]
D1524		Suvorexant	C23H23ClN6O2	24965990	Minor		Inter Info	[4], [34], [35]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[4], [34], [35]
D1660		Tucatinib	C26H24N8O2	51039094	Minor		Inter Info	[4], [34], [35]
D0208		Brivaracetam	C11H20N2O2	9837243	Minor		Inter Info	[6], [244]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[4], [34], [35]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[4], [34], [35]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[4], [34], [35]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[4], [34], [35]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[4], [34], [35]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[4], [34], [35]
D0413		Dalfopristin	C34H50N4O9S	6323289	Minor		Inter Info	[4], [34], [35]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[4], [34], [35]
D0426		Darunavir	C27H37N3O7S	213039	Minor		Inter Info	[4], [34], [35]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[4], [34], [35]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[4], [34], [35]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Minor		Inter Info	[4], [34], [35]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[4], [34], [35]
D0793		Imatinib	C29H31N7O	5291	Minor		Inter Info	[4], [34], [35]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[4], [34], [35]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[4], [34], [35]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[4], [34], [35]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[4], [34], [35]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[4], [34], [35]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[4], [34], [35]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[4], [34], [35]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[4], [34], [35]
D1541		Telaprevir	C36H53N7O6	3010818	Minor		Inter Info	[4], [34], [35]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[4], [34], [35]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[4], [34], [35]
	CYP450 enzyme induction					Drug Num: 304
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[1], [2], [3]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[4], [6], [7]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[8], [4], [6], [9], [10], [11], [1], [2], [3], [12]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[8], [4], [6], [9], [10], [11], [1], [2], [3], [12]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[8], [4], [6], [9], [10], [11], [1], [2], [3], [12]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[8], [4], [6], [9], [10], [11], [1], [2], [3], [12]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[18], [19]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[20]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[8], [4], [6], [9], [10], [11], [1], [2], [3], [12]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[33]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[34], [35]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[34], [35]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[38], [39], [34], [35], [37], [40], [41]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[48]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[49]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[50]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[4], [6], [51]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[6], [52]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[53], [54]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[6], [55], [56]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[57]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[4], [6], [58]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[59], [60]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[62]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[8], [4], [6], [63], [64], [65], [66]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[67]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[6], [68]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[69]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[70], [34], [35]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[71], [72]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[73]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[4], [74]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[75]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[76]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[77]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[78]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[79]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[80]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[34], [35]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[82]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[83]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[84]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[85]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[86]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[6], [87]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[34], [35]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[88]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[4], [6], [89]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[92]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[34], [35], [93]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[34], [35]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[94]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[96]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[34], [35]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[34], [35], [93]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[4], [6], [97]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[98]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[99]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[100], [101]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[4], [102], [34], [35], [103], [37]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[104]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[105]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[4], [6], [106]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[107]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[6], [108]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[109]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[4], [6], [110]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[4], [111], [6], [112]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[4], [113]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[114]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[6], [115]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[116]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[34], [35], [93]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[34], [35]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[117]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[6], [63], [118]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[119]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[120]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[6], [121]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[8], [6], [122], [123], [124]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[125]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[6], [126]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[127]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[128]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[129]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[38], [39], [34], [35], [37], [40], [41]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[34], [35]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[34], [35]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[130], [131], [132]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[34], [35]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[34], [35]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[4], [6], [34], [35]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[6], [133]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[34], [35]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[164]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[4], [39], [34], [35], [37]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[4], [6], [165]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[34], [35]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[34], [35], [166], [37]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[34], [35]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[4], [6], [167]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[168], [169], [170], [171], [172]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[173]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[4], [102], [34], [35], [103], [37]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[171]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[4], [6], [167]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[4], [6], [167]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[70], [34], [35]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[4], [102], [34], [35], [103], [37]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[4], [6], [184]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[185]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[34], [35]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[186]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[38], [39], [34], [35], [37], [40], [41]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[34], [35]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[6], [187], [188]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[38], [39], [34], [35], [37], [40], [41]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[190], [191], [196]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[4], [102], [34], [35], [103], [37]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[34], [40], [41]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[4], [205]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[206], [207], [208]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[4], [6], [167]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[34], [35], [93]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[4], [6], [167]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[209], [210], [211], [212]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[34], [35]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[34], [35]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[38], [39], [34], [35], [37], [40], [41]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[34], [35]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[70], [34], [35]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[70], [34], [35]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[34], [35]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[34], [35]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[34], [35]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[34], [35]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[213]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[214], [4], [215], [216]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[34], [35]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[217]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[218], [219], [220]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[34], [35]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[34], [35], [93]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[34], [35]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[34], [35]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[38], [39], [34], [35], [37], [40], [41]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[34], [35]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[4], [6], [221]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[4], [6], [222], [223]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[34], [35], [93]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[224]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[34], [35]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[34], [35]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[4], [6], [225]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[4], [6], [222], [223]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[226], [227], [228], [229]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[6], [230]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[231], [4], [6], [227], [232]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[6], [233], [234]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[34], [35], [103], [37]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[34], [35]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [39], [34], [35], [103], [37]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[6], [235], [236], [237]
D0028		Albendazole	C12H15N3O2S	2082	Minor		Inter Info	[39], [34], [35], [103], [37]
D0035		Alfentanil	C21H32N6O3	51263	Minor		Inter Info	[39], [34], [35], [103], [37]
D0036		Alfuzosin	C19H27N5O4	2092	Minor		Inter Info	[39], [34], [35], [103], [37]
D0041		Almotriptan	C17H25N3O2S	123606	Minor		Inter Info	[39], [34], [35], [103], [37]
D0045		Alprazolam	C17H13ClN4	2118	Minor		Inter Info	[39], [34], [35], [103], [37]
D0053		Ambrisentan	C22H22N2O4	6918493	Minor		Inter Info	[39], [34], [35], [103], [37]
D0069		Amlodipine	C20H25ClN2O5	2162	Minor		Inter Info	[39], [34], [35], [103], [37]
D0099		Apremilast	C22H24N2O7S	11561674	Minor		Inter Info	[39], [34], [35], [103], [37]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Minor		Inter Info	[39], [34], [35], [103], [37]
D0096		Apixaban	C25H25N5O4	10182969	Minor		Inter Info	[39], [34], [35], [103], [37]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Minor		Inter Info	[39], [34], [35], [103], [37]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Minor		Inter Info	[39], [34], [35], [103], [37]
D0227		Cabazitaxel	C45H57NO14	9854073	Minor		Inter Info	[39], [34], [35], [103], [37]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[39], [34], [35], [103], [37]
D0605		Esterified estrogens	NA	NA	Minor		Inter Info	[39], [34], [35], [103], [37]
D0655		Fesoterodine	C26H37NO3	6918558	Minor		Inter Info	[39], [34], [35], [103], [37]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[238]
D0785		Ibrutinib	C25H24N6O2	24821094	Minor		Inter Info	[39], [34], [35], [103], [37]
D0866		Istradefylline	C20H24N4O4	5311037	Minor		Inter Info	[39], [34], [35], [103], [37]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Minor		Inter Info	[39], [34], [35], [103], [37]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Minor		Inter Info	[39], [34], [35], [103], [37]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[239]
D1101		Naldemedine	C32H34N4O6	54732242	Minor		Inter Info	[39], [34], [35], [103], [37]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[39], [34], [35], [103], [37]
D1124		Neratinib	C30H29ClN6O3	9915743	Minor		Inter Info	[39], [34], [35], [103], [37]
D1313		Ponatinib	C29H27F3N6O	24826799	Minor		Inter Info	[39], [34], [35], [103], [37]
D1408		Riociguat	C20H19FN8O2	11304743	Minor		Inter Info	[39], [34], [35], [103], [37]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[39], [34], [35], [103], [37]
D1600		Tofacitinib	C16H20N6O	9926791	Minor		Inter Info	[39], [34], [35], [103], [37]
D1666		Upadacitinib	C17H19F3N6O	58557659	Minor		Inter Info	[39], [34], [35], [103], [37]
D1696		Vilazodone	C26H27N5O2	6918314	Minor		Inter Info	[39], [34], [35], [103], [37]
D0115		Astemizole	C28H31FN4O	2247	Minor		Inter Info	[39], [34], [35], [103], [37]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[39], [34], [35], [103], [37]
D0128		Avanafil	C23H26ClN7O3	9869929	Minor		Inter Info	[39], [34], [35], [103], [37]
D0170		Bepridil	C24H34N2O	2351	Minor		Inter Info	[39], [34], [35], [103], [37]
D0172		Betamethasone	C22H29FO5	9782	Minor		Inter Info	[39], [34], [35], [103], [37]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[6], [240], [241], [242], [243]
D0219		Buprenorphine	C29H41NO4	644073	Minor		Inter Info	[39], [34], [35], [103], [37]
D0223		Busulfan	C6H14O6S2	2478	Minor		Inter Info	[39], [34], [35], [103], [37]
D0268		Caspofungin	C52H88N10O15	2826718	Minor		Inter Info	[39], [34], [35], [103], [37]
D0303		Cerivastatin	C26H34FNO5	446156	Minor		Inter Info	[39], [34], [35], [103], [37]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[39], [34], [35], [103], [37]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Minor		Inter Info	[39], [34], [35], [103], [37]
D0362		Clonazepam	C15H10ClN3O3	2802	Minor		Inter Info	[39], [34], [35], [103], [37]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Minor		Inter Info	[39], [35], [103]
D0379		Codeine	C18H21NO3	5284371	Minor		Inter Info	[39], [34], [35], [103], [37]
D0380		Colchicine	C22H25NO6	6167	Minor		Inter Info	[39], [34], [35], [103], [37]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Minor		Inter Info	[39], [34], [35], [103], [37]
D0398		Cyclobenzaprine	C20H21N	2895	Minor		Inter Info	[39], [34], [35], [103], [37]
D0419		Dapsone	C12H12N2O2S	2955	Minor		Inter Info	[39], [34], [35], [103], [37]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[245], [246], [247]
D0424		Darifenacin	C28H30N2O2	444031	Minor		Inter Info	[39], [34], [35], [103], [37]
D0476		Diclofenac	C14H11Cl2NO2	3033	Minor		Inter Info	[39], [34], [35], [103], [37]
D0487		Diethylstilbestrol	C18H20O2	448537	Minor		Inter Info	[39], [34], [35], [103], [37]
D0493		Dihydrocodeine	C18H23NO3	5284543	Minor		Inter Info	[39], [35], [103]
D0508		Disopyramide	C21H29N3O	3114	Minor		Inter Info	[39], [34], [35], [103], [37]
D0511		Docetaxel	C43H53NO14	148124	Minor		Inter Info	[39], [34], [35], [103], [37]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[39], [34], [35], [103], [37]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[39], [34], [35], [103], [37]
D0528		Doxorubicin	C27H29NO11	31703	Minor		Inter Info	[39], [34], [35], [103], [37]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Minor		Inter Info	[39], [35], [103]
D0533		Dronabinol	C21H30O2	16078	Minor		Inter Info	[39], [34], [35], [103], [37]
D0542		Dutasteride	C27H30F6N2O2	6918296	Minor		Inter Info	[39], [34], [35], [103], [37]
D0557		Eletriptan	C22H26N2O2S	77993	Minor		Inter Info	[39], [34], [35], [103], [37]
D0585		Eplerenone	C24H30O6	443872	Minor		Inter Info	[39], [34], [35], [103], [37]
D0595		Erlotinib	C22H23N3O4	176870	Minor		Inter Info	[39], [34], [35], [103], [37]
D0604		Estazolam	C16H11ClN4	3261	Minor		Inter Info	[39], [34], [35], [103], [37]
D0606		Estradiol	C18H24O2	5757	Minor		Inter Info	[39], [34], [35], [103], [37]
D0609		Estrone	C18H22O2	5870	Minor		Inter Info	[39], [34], [35], [103], [37]
D0610		Estrone sulfate	C18H22O5S	3001028	Minor		Inter Info	[39], [35], [103]
D0612		Eszopiclone	C17H17ClN6O3	969472	Minor		Inter Info	[39], [34], [35], [103], [37]
D0620		Ethosuximide	C7H11NO2	3291	Minor		Inter Info	[39], [34], [35], [103], [37]
D0627		Etoposide	C29H32O13	36462	Minor		Inter Info	[39], [34], [35], [103], [37]
D0671		Fludrocortisone	C21H29FO5	31378	Minor		Inter Info	[39], [34], [35], [103], [37]
D0679		Flurazepam	C21H23ClFN3O	3393	Minor		Inter Info	[39], [34], [35], [103], [37]
D0713		Gefitinib	C22H24ClFN4O3	123631	Minor		Inter Info	[39], [34], [35], [103], [37]
D0738		Granisetron	C18H24N4O	5284566	Minor		Inter Info	[39], [34], [35], [103], [37]
D0748		Halazepam	C17H12ClF3N2O	31640	Minor		Inter Info	[39], [34], [35], [103], [37]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Minor		Inter Info	[39], [34], [35], [103], [37]
D0750		Haloperidol	C21H23ClFNO2	3559	Minor		Inter Info	[39], [34], [35], [103], [37]
D0751		Halothane	C2HBrClF3	3562	Minor		Inter Info	[39], [34], [35], [103], [37]
D0773		Hydrocortisone	C21H30O5	5754	Minor		Inter Info	[39], [34], [35], [103], [37]
D0870		Ivermectin	C48H74O14	6321424	Minor		Inter Info	[39], [34], [35], [103], [37]
D0873		Ixabepilone	C27H42N2O5S	6445540	Minor		Inter Info	[39], [34], [35], [103], [37]
D0907		Letrozole	C17H11N5	3902	Minor		Inter Info	[39], [34], [35], [103], [37]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[248]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[249], [250], [251], [252]
D0950		Loratadine	C22H23ClN2O2	3957	Minor		Inter Info	[39], [34], [35], [103], [37]
D0993		Megestrol acetate	C24H32O4	11683	Minor		Inter Info	[39], [35], [103]
D1041		Methylprednisolone	C22H30O5	6741	Minor		Inter Info	[39], [34], [35], [103], [37]
D1143		Nitisinone	C14H10F3NO5	115355	Minor		Inter Info	[39], [34], [35], [103], [37]
D1181		Ondansetron	C18H19N3O	4595	Minor		Inter Info	[39], [34], [35], [103], [37]
D1202		Oxybutynin	C22H31NO3	4634	Minor		Inter Info	[39], [34], [35], [103], [37]
D1212		Paclitaxel	C47H51NO14	36314	Minor		Inter Info	[39], [34], [35], [103], [37]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Minor		Inter Info	[39], [35], [103]
D1292		Pimozide	C28H29F2N3O	16362	Minor		Inter Info	[39], [34], [35], [103], [37]
D1294		Pioglitazone	C19H20N2O3S	4829	Minor		Inter Info	[39], [34], [35], [103], [37]
D1332		Prednisolone	C21H28O5	5755	Minor		Inter Info	[39], [34], [35], [103], [37]
D1334		Prednisone	C21H26O5	5865	Minor		Inter Info	[39], [34], [35], [103], [37]
D1348		Progesterone	C21H30O2	5994	Minor		Inter Info	[39], [34], [35], [103], [37]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[39], [34], [35], [103], [37]
D1368		Quetiapine	C21H25N3O2S	5002	Minor		Inter Info	[39], [34], [35], [103], [37]
D1370		Quinestrol	C25H32O2	9046	Minor		Inter Info	[39], [34], [35], [103], [37]
D1371		Quinidine	C20H24N2O2	441074	Minor		Inter Info	[39], [34], [35], [103], [37]
D1372		Quinine	C20H24N2O2	3034034	Minor		Inter Info	[39], [34], [35], [103], [37]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Minor		Inter Info	[39], [34], [35], [103], [37]
D1449		Saxagliptin	C18H25N3O2	11243969	Minor		Inter Info	[39], [34], [35], [103], [37]
D1465		Sildenafil	C22H30N6O4S	135398744	Minor		Inter Info	[39], [34], [35], [103], [37]
D1491		Solifenacin	C23H26N2O2	154059	Minor		Inter Info	[39], [34], [35], [103], [37]
D1512		Sufentanil	C22H30N2O2S	41693	Minor		Inter Info	[39], [34], [35], [103], [37]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[39], [34], [35], [103], [37]
D1549		Temsirolimus	C56H87NO16	6918289	Minor		Inter Info	[39], [34], [35], [103], [37]
D1551		Teniposide	C32H32O13S	452548	Minor		Inter Info	[39], [34], [35], [103], [37]
D1558		Testosterone	C19H28O2	6013	Minor		Inter Info	[39], [34], [35], [103], [37]
D1559		Testosterone (topical)	C19H28O2	6013	Minor		Inter Info	[39], [35], [103]
D1578		Tiagabine	C20H25NO2S2	60648	Minor		Inter Info	[39], [34], [35], [103], [37]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[39], [34], [35], [103], [37]
D1624		Trazodone	C19H22ClN5O	5533	Minor		Inter Info	[39], [34], [35], [103], [37]
D1626		Tretinoin	C20H28O2	444795	Minor		Inter Info	[39], [34], [35], [103], [37]
D1628		Triamcinolone	C21H27FO6	31307	Minor		Inter Info	[39], [34], [35], [103], [37]
D1674		Valdecoxib	C16H14N2O3S	119607	Minor		Inter Info	[39], [34], [35], [103], [37]
D1682		Vardenafil	C23H32N6O4S	135400189	Minor		Inter Info	[39], [34], [35], [103], [37]
D1697		Vinblastine	C46H58N4O9	13342	Minor		Inter Info	[39], [34], [35], [103], [37]
D1698		Vincristine	C46H56N4O10	5978	Minor		Inter Info	[39], [34], [35], [103], [37]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Minor		Inter Info	[39], [35], [103]
D1700		Vinorelbine	C45H54N4O8	5311497	Minor		Inter Info	[39], [34], [35], [103], [37]
D1721		Zileuton	C11H12N2O2S	60490	Minor		Inter Info	[39], [34], [35], [103], [37]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[39], [34], [35], [103], [37]
D1730		Zonisamide	C8H8N2O3S	5734	Minor		Inter Info	[39], [34], [35], [103], [37]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[4], [5]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[6], [16], [17]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[6], [16], [17]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[44], [45], [46]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[44], [45], [46]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[44], [45], [46]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[44], [45], [46]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[44], [45], [46]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[44], [45], [46]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[44], [45], [46]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[44], [45], [46]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[44], [45], [46]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[44], [45], [46]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[44], [45], [46]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[44], [45], [46]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[44], [45], [46]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[44], [45], [46]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[44], [45], [46]

References
1	Product Information. Mycobutin (rifabutin). Pharmacia and Upjohn, Kalamazoo, MI.
2	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
3	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
4	Cerner Multum, Inc. "Australian Product Information.".
5	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
6	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
7	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
8	Canadian Pharmacists Association.
9	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
10	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
11	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
12	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
13	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
14	Priskorn M, Larsen F, Segonzac A, Moulin M "Pharmacokinetic interaction study of citalopram and cimetidine in healhy subjects." Eur J Clin Pharmacol 52 (1997): 241-2. [PMID: 9218934]
15	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
16	Thevasagyam M, Jindal M, Allsop P, Oates J "Does epinephrine infiltration in septoplasty make any difference?" Eur Arch Otorhinolaryngol 264 (2007): 1175-8.[PMID: 17530270]
17	Product Information. Cocaine Hydrochloride (cocaine topical). Mallinckrodt Medical Inc, St. Louis, MO.
18	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
19	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
20	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
21	Altice FL, Friedland GH, Cooney EL "Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone." AIDS 13 (1999): 957-62. [PMID: 10371177]
22	Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
23	Bending MR, Skacel PO "Rifampicin and methadone withdrawal." Lancet 1 (1977): 1211. [PMID: 68314]
24	Finelli PF "Phenytoin and methadone tolerance." N Engl J Med 294 (1976): 227. [PMID: 1244546]
25	Holmes VF "Rifampin-induced methadone withdrawal in AIDS." J Clin Psychopharmacol 10 (1991): 443-4. [PMID: 2286719]
26	Kreek MJ, Garfield JW, Gutjahr CL, Giusti LM "Rifampin-induced methadone withdrawal." N Engl J Med 294 (1976): 1104-6. [PMID: 1256526]
27	Liu S-J, Wang RI "Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome." Am J Psychiatry 141 (1984): 1287-8. [PMID: 6486271]
28	Otero MJ, Fuertes A, Sanchez R, Luna G "Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert." AIDS 13 (1999): 1004-5. [PMID: 10371190]
29	Pinzani V, Faucherre V, Peyriere H, Blayac JP "Methadone withdrawal symptoms with nevirapine and efavirenz." Ann Pharmacother 34 (2000): 405-7. [PMID: 10917395]
30	Product Information. Diskets (methadone). Cebert Pharmaceuticals Inc, Birmingham, AL.
31	Raistrick D, Hay A, Wolff K "Methadone maintenance and tuberculosis treatment." BMJ 313 (1996): 925-6. [PMID: 8876100]
32	Tong TG, Pond SM, Kreek MJ, et al "Phenytoin-induced methadone withdrawal." Ann Intern Med 94 (1981): 349-51. [PMID: 7224382]
33	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
34	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
35	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
36	Grozinger M, Hartter S, Hiemke C, Griese EU, Roschke J "Interaction of modafinil and clomipramine as comedication in a narcoleptic patient." Clin Neuropharmacol 21 (1998): 127-9. [PMID: 9579300]
37	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
38	Barry M, Gibbons S, Back D, Mulcahy F "Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations." Clin Pharmacokinet 32 (1997): 194-209. [PMID: 9084959]
39	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
40	Sommadossi JP "HIV protease inhibitors: pharmacologic and metabolic distinctions." AIDS 13 (1999): s29-40. [PMID: 10546783]
41	Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9. [PMID: 10930147]
42	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers." J Clin Pharmacol 42 (2002): 205-14. [PMID: 11831544]
43	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
44	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
45	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
46	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
47	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
48	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
49	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
50	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
51	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
52	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
53	Pithavala YK, Tortorici M, Toh M, et al "Effect of rifampin on the pharmacokinetics of axitinib (AG-013736) in Japanese and Caucasian healthy volunteers." Cancer Chemother Pharmacol 65 (2010): 563-70. [PMID: 19603168]
54	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
55	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
56	Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
57	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
58	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
59	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
60	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
61	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
62	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
63	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
64	Product Information. Genvoya (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
65	Product Information. Tybost (cobicistat). Gilead Sciences, Foster City, CA.
66	Smith DS, Fujimoto JM "Alterations produced by novobiocin during biliary excretion of morphine, morphine-3-glucuronide and other compounds." J Pharmacol Exp Ther 188 (1974): 504-15. [PMID: 4273910]
67	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
68	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
69	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
70	Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
71	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
72	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
73	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
74	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
75	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
76	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
77	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
78	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
79	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
80	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
81	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
82	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
83	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
84	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
85	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
86	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
87	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
88	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
89	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
90	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
91	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
92	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
93	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
94	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
95	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
96	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
97	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
98	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
99	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
100	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
101	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
102	Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
103	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
104	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
105	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
106	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
107	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
108	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
109	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
110	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
111	Cerner Multum, Inc. "Canadian Product Information.".
112	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
113	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
114	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
115	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
116	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
117	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
118	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
119	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
120	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
121	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
122	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
123	Teng R, Mitchell P, Butler K "Effect of rifampicin on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy subjects." Eur J Clin Pharmacol 69 (2013): 877-83. [PMID: 23093043]
124	Weeks P, Sieg A, Vahdat K, Raissi F, Nathan S "Improved ticagrelor antiplatelet effect on discontinuation of phenytoin." Ann Pharmacother 48 (2014): 644-7. [PMID: 24477376]
125	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
126	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
127	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
128	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
129	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
130	Kivisto KT, Lamberg TS, Neuvonen PJ "Interactions of buspirone with itraconazole and rifampicin: Effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone." Pharmacol Toxicol 84 (1999): 94-7. [PMID: 10068153]
131	Lamberg TS, Kivisto KT, Neuvonen PJ "Concentrations and effects of buspirone are considerably reduced by rifampicin." Br J Clin Pharmacol 45 (1998): 381-5. [PMID: 9578186]
132	Product Information. Buspar (buspirone). Bristol-Myers Squibb, Princeton, NJ.
133	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
134	Dequardo JR "Modafinil-associated clozapine toxicity." Am J Psychiatry 159 (2002): 1243-1244. [PMID: 12091210]
135	Hedaya MA, El-Afify DR, El-Maghraby GM "The effect of ciprofloxacin and clarithromycin on sildenafil oral bioavailability in human volunteers." Biopharm Drug Dispos 27 (2006): 103-10. [PMID: 16372380]
136	Herrlin K, Segerdahl M, Gustafsson LL, Kalso E "Methadone, ciprofloxacin, and adverse drug reactions." Lancet 356 (2000): 2069-70. [PMID: 11145498]
137	McLellan RA, Drobitch RK, Monshouwer M, Renton KW "Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human." Drug Metab Dispos 24 (1996): 1134-8. [PMID: 8894516]
138	Product Information. Pletal (cilostazol). Otsuka American Pharmaceuticals, Rockville, MD.
139	Sawant RD "Rhabdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin." Can J Clin Pharmacol 16 (2009): e78-9. [PMID: 19151423]
140	Shahzadi A, Javed I, Aslam B, et al. "Therapeutic effects of ciprofloxacin on the pharmacokinetics of carbamazepine in healthy adult male volunteers." Pak J Pharm Sci 24 (2011): 63-8. [PMID: 21190921]
141	Sriwiriyajan S, Samaeng M, Ridtitid W, Mahatthanatrakul W, Wongnawa M "Pharmacokinetic interactions between ciprofloxacin and itraconazole in healthy male volunteers." Biopharm Drug Dispos 32 (2011): 168-74. [PMID: 21360715]
142	Suri A, Bramer SL "Effect of omeprazole on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 53-9. [PMID: 10702887]
143	Suri A, Forbes WP, Bramer SL "Effects of CYP3A inhibition on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 61-8. [PMID: 10702888]
144	Product Information. Onfi (clobazam). Lundbeck Inc, Deerfield, IL.
145	Collet JP, Hulot JS, Pena A, et al. "Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study." Lancet 373 (2009): 309-17. [PMID: 19108880]
146	Frere C, Cuisset T, Morange PE, et al. "Effect of Cytochrome P450 Polymorphisms on Platelet Reactivity After Treatment With Clopidogrel in Acute Coronary Syndrome." Am J Cardiol 101 (2008): 1088-1093. [PMID: 18394438]
147	Gilard M, Arnaud B, Cornily JC, et al "Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study." J Am Coll Cardiol 51 (2008): 256-60. [PMID: 18206732]
148	Gilard M, Arnaud B, Le Gal G, Abgrall JF, Boschat J "Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin." J Thromb Haemost 4 (2006): 2508-9. [PMID: 16898956]
149	Hulot JS, Bura A, Villard E, et al. "Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects." Blood (2006):. [PMID: 16772608]
150	Juurlink DN, Gomes T, Ko DT, et al "A population-based study of the drug interaction between proton pump inhibitors and clopidogrel." CMAJ 180 (2009): 713-8. [PMID: 19176635]
151	Lau WC, Gurbel PA "The drug-drug interaction between proton pump inhibitors and clopidogrel." CMAJ 180 (2009): 699-700. [PMID: 19332744]
152	Li XQ, Andersson TB, Ahlstrom M, Weidolf L "Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities." Drug Metab Dispos 32 (2004): 821-7. [PMID: 15258107]
153	Mega JL, Close SL, Wiviott SD, et al. "Cytochrome p-450 polymorphisms and response to clopidogrel." N Engl J Med 360 (2009): 354-62. [PMID: 19106084]
154	Moayyedi P, Sadowski DC "Proton pump inhibitors and clopidogrel -- hazardous drug interaction or hazardous interpretation of data?" Can J Gastroenterol 23 (2009): 251-2. [PMID: 19373416]
155	Ohyama K, Nakajima M, Suzuki M, Shimada N, Yamazaki H, Yokoi T "Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions." Br J Clin Pharmacol 49 (2000): 244-53. [PMID: 10718780]
156	Pezalla E, Day D, Pulliadath I "Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors." J Am Coll Cardiol 52 (2008): 1038-9. [PMID: 18786491]
157	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
158	Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
159	Product Information. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ.
160	Siller-Matula JM, Spiel AO, Lang IM, Kreiner G, Christ G, Jilma B "Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel." Am Heart J 157 (2009): 148.e1-5. [PMID: 19081411]
161	Simon T, Verstuyft C, Mary-Krause M, et al "Genetic determinants of response to clopidogrel and cardiovascular events." N Engl J Med 360 (2009): 363-75. [PMID: 19106083]
162	Small DS, Farid NA, Payne CD, et al. "Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel." J Clin Pharmacol 48 (2008): 475-84. [PMID: 18303127]
163	Varenhorst C, Janes S, Erlinge D, et al "Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease." Eur Heart J 30 (2009): 1744-52. [PMID: 19429918]
164	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
165	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
166	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
167	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
168	Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6. [PMID: 1558427]
169	Lledo P, Abrams SM, Johnston A, Patel M, Pearson RM, Turner P. Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine. Eur J Clin Pharmacol. 1993;44(1):63-67. [PMID: 8436157]
170	Product Information. Cardizem (diltiazem). Hoechst Marion-Roussel Inc, Kansas City, MO.
171	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
172	Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8. [PMID: 9385296]
173	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
174	Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5. [PMID: 9861909]
175	Corkeron MA "Serotonin syndrome - a potentially fatal complication of antidepressant therapy." Med J Aust 163 (1995): 481-2. [PMID: 7476638]
176	Laird LK "Issues in the monopharmacotherapy and polypharmacotherapy of obsessive-compulsive disorder." Psychopharmacol Bull 32 (1996): 569-78. [PMID: 8993077]
177	Lane R, Baldwin D "Selective serotonin reuptake inhibitor--induced serotonin syndrome: review." J Clin Psychopharmacol 17 (1997): 208-21. [PMID: 9169967]
178	Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6. [PMID: 8909274]
179	Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763. [PMID: 9330840]
180	Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8. [PMID: 8257462]
181	Nijhawan PK, Katz G, Winter S "Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission." Crit Care Med 24 (1996): 1086-9. [PMID: 8681579]
182	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
183	Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13. [PMID: 2035713]
184	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
185	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
186	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
187	Kiechel JR, Lavene D, Guerret M, Comoy E, Godin M, Fillastre JP "Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure." Eur J Clin Pharmacol 25 (1983): 463-6. [PMID: 6360692]
188	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
189	Crews KR, Stewart CF, Jones-Wallace D, et al "Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy." Clin Cancer Res 8 (2002): 2202-9. [PMID: 12114421]
190	Di YM, Li CG, Xue CC, Zhou SF "Clinical drugs that interact with St. John's wort and implication in drug development." Curr Pharm Des 14 (2008): 1723-42. [PMID: 18673195]
191	Friedman HS, Petros WP, Friedman AH, et al "Irinotecan therapy in adults with recurrent or progressive malignant glioma." J Clin Oncol 17 (1999): 1516-25. [PMID: 10334539]
192	Innocenti F, Undevia SD, Ramirez J, et al. "A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital." Clin Pharmacol Ther 76 (2004): 490-502. [PMID: 15536463]
193	Kuhn JG "Influence of anticonvulsants on the metabolism and elimination of irinotecan. A North American Brain Tumor Consortium preliminary report." Oncology (Williston Park 16(8 Suppl 7) (2002): 33-40. [PMID: 12199631]
194	Hu ZP, Yang XX, Chen X, et al. A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.?Curr Drug Metab. 2007;8(2):157-171. [PMID: 17305494]
195	Mathijssen RH, Verweij J, De Bruijn P, Loos WJ, Sparreboom A "Effects of St. John's Wort on Irinotecan Metabolism." J Natl Cancer Inst 94 (2002): 1247-9. [PMID: 12189228]
196	Minami H, Lad TE, Nicholas MK, Vokes EE, Ratain MJ "Pharmacokinetics and pharmacodynamics of 9-aminocamptothecin infused over 72 hours in phase II studies." Clin Cancer Res 5 (1999): 1325-30. [PMID: 10389915]
197	Murry DJ, Cherrick I, Salama V, et al. "Influence of phenytoin on the disposition of irinotecan: a case report." J Pediatr Hematol Oncol 24 (2002): 130-3. [PMID: 11990699]
198	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
199	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
200	Hofland KF, Hansen S, Sorensen M, et al. Neoadjuvant bevacizumab and irinotecan versus bevacizumab and temozolomide followed by concomitant chemoradiotherapy in newly diagnosed glioblastoma multiforme: A randomized phase II study.?Acta Oncol. 2014;53(7):939-944. [PMID: 24456504]
201	Santos A, Zanetta S, Cresteil T, et al "Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans." Clin Cancer Res 6 (2000): 2012-20. [PMID: 10815927]
202	Yonemori K, Takeda Y, Toyota E, Kobayashi N, Kudo K "Potential interactions between irinotecan and rifampin in a patient with small-cell lung cancer." Int J Clin Oncol 9 (2004): 206-9. [PMID: 15221608]
203	Zamboni WC, Gajjar AJ, Heideman RL, et al "Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma." Clin Cancer Res 4 (1998): 783-9. [PMID: 9533548]
204	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
205	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
206	Kobayashi K, Mimura N, Fujii H, et al "Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate." Clin Cancer Res 6 (2000): 3297-303. [PMID: 10955816]
207	Product Information. Provera (medroxyprogesterone). Pharmacia and Upjohn, Kalamazoo, MI.
208	Lundgren S, Lonning PE, Aakvaag A, Kvinnsland S, Lnning PE "Influence of aminoglutethimide on the metabolism of medroxyprogesterone acetate and megestrol acetate in postmenopausal patients with advanced breast cancer." Cancer Chemother Pharmacol 27 (1990): 101-5. [PMID: 2249324]
209	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
210	Sitsen JM, Maris FA, Timmer CJ "Drug-drug interaction studies with mirtazapine and carbamazepine in healthy male subjects." Eur J Drug Metab Pharmacokinet 26 (2001): 109-21. [PMID: 11554425]
211	Spaans E, Van Den Heuvel MW, Schnabel PG, et al. "Concomitant use of mirtazapine and phenytoin: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 58 (2002): 423-9. [PMID: 12242602]
212	Timmer CJ, Sitsen JMA, Delbressine LP "Clinical pharmacokinetics of mirtazapine." Clin Pharmacokinet 38 (2000): 461-74. [PMID: 10885584]
213	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
214	Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
215	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
216	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
217	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
218	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
219	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT "Rifampin decreases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 68 (2000): 495-500. [PMID: 11103752]
220	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
221	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
222	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
223	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
224	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
225	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
226	Biochem Pharmacol "Variable contribution of cytochromes P450 2D6, 2C9, and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes." Biochem Pharmacol 53 (1997): 171-8. [PMID: 9037249]
227	Kivisto KT, Villikka K, Nyman L, Anttila M, Neuvonen PJ "Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin." Clin Pharmacol Ther 64 (1998): 648-54. [PMID: 9871429]
228	Lien EA, Anker G, Lonning PE, et al "Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide." Cancer Res 50 (1990): 5851-7. [PMID: 2393854]
229	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
230	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
231	Berthou F, Dreano Y, Belloc C, Kangas L, Gautier JC, Beaune P "Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes." Biochem Pharmacol 47 (1994): 1883-95. [PMID: 8204106]
232	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
233	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
234	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
235	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
236	Villikka K, Kivisto KT, Luurila H, Neuvonen PJ "Rifampin reduces plasma concentrations and effects of zolpidem." Clin Pharmacol Ther 62 (1997): 629-34. [PMID: 9433391]
237	Vlase L, Popa A, Neag M, Muntean D, Baldea I, Leucuta SE "Pharmacokinetic Interaction Between Zolpidem and Carbamazepine in Healthy Volunteers." J Clin Pharmacol (2010):. [PMID: 21098143]
238	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
239	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
240	Hellmann A, Rule S, Walewski J, et al. "Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or Non-Hodgkin's lymphoma." Clin Pharmacokinet 50 (2011): 781-91. [PMID: 22087865]
241	Pekol T, Daniels JS, Labutti J, et al "Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites." Drug Metab Dispos 33 (2005): 771-7. [PMID: 15764713]
242	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
243	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
244	Product Information. Briviact (brivaracetam). UCB Pharma Inc, Smyrna, GA.
245	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
246	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
247	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
248	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
249	Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95. [PMID: 5428253]
250	Perucca E, Richens A "Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients." Br J Clin Pharmacol 8 (1979): 21-31. [PMID: 552293]
251	Perucca E, Ruprah M, Richens A, Park BK, Betteridge DJ, Hedges AM "Effect of low-dose phenobarbitone on five indirect indices of hepatic microsomal enzyme induction and plasma lipoproteins in normal subjects." Br J Clin Pharmacol 12 (1981): 592-6. [PMID: 6117310]
252	Reichel C, Skodra T, Nacke A, Spengler U, Sauerbruch T "The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans." Br J Clin Pharmacol 46 (1998): 535-9. [PMID: 9862241]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence