Details of Drug

Drug General Information (ID: D0098)
Drug Name	Apraclonidine
Drug Type	Small molecule
Drug Synonymous	Aplonidine; Apraclonidina; Apraclonidinum; Iopidine; Iopidine Eye; ALO 2145; Apraclonidina [INN-Spanish]; Apraclonidine (INN); Apraclonidine [INN:BAN]; Apraclonidinum [INN-Latin]; Iopidine (TN); P-aminoclonidine; Para-aminoclonidine; 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; 2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; 2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride; 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine; 4-Aminoclonidine Click to Show/Hide
Disease Class	9C40: Optic nerve disorder
Therapeutic Class	Ophthalmic Glaucoma Agents
Structure
Structure	3D Structure		2D Structure
Formula	C9H10Cl2N4
InChI	1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)
InChIKey	IEJXVRYNEISIKR-UHFFFAOYSA-N
Canonical SMILES	C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl
External Link
	Pubchem ID	2216
	CAS Number	66711-21-5
	CHEBI ID	2788
	TTD ID	D0MT0M

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects
Relation Graph

Full list of drugs interacting with Apraclonidine
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 201
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[4], [5], [6]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[4], [5], [6]
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[4], [5], [6]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[2], [8], [9]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[2], [8], [9]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[4], [5], [6]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[4], [5], [6]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[4], [5], [6]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[4], [5], [6]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[4], [5], [6]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[4], [5], [6]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[4], [5], [6]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[4], [5], [6]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[4], [5], [6]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[4], [5], [6]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[4], [5], [6]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [5], [6]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[4], [5], [6]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[4], [5], [6]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[4], [5], [6]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[4], [5], [6]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[4], [5], [6]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[4], [5], [6]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[4], [5], [6]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[2], [8], [9]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[4], [5], [6]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[4], [5], [6]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[4], [5], [6]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[2], [8], [9]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[4], [5], [6]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[4], [5], [6]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[4], [5], [6]
D0488		Difenoxin	C28H28N2O2	34328	Moderate		Inter Info	[4], [5], [6]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[4], [5], [6]
D0504		Diphenoxylate	C30H32N2O2	13505	Moderate		Inter Info	[4], [5], [6]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[4], [5], [6]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[4], [5], [6]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[4], [5], [6]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[4], [5], [6]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[4], [5], [6]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[4], [5], [6]
D0698		Fospropofol	C13H21O5P	3038498	Moderate		Inter Info	[4], [5], [6]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[4], [5], [6]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[4], [5], [6]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[4], [5], [6]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[4], [5], [6]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[4], [5], [6]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[4], [5], [6]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[4], [5], [6]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[4], [5], [6]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[4], [5], [6]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[4], [5], [6]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[4], [5], [6]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[4], [5], [6]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[4], [5], [6]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[4], [5], [6]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[4], [5], [6]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[4], [5], [6]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[4], [5], [6]
D1183		Opium	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[4], [5], [6]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[4], [5], [6]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[4], [5], [6]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[4], [5], [6]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[4], [5], [6]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[4], [5], [6]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[4], [5], [6]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[4], [5], [6]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[4], [5], [6]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[4], [5], [6]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[4], [5], [6]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[4], [5], [6]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[4], [5], [6]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[4], [5], [6]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[4], [5], [6]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[4], [5], [6]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[4], [5], [6]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[4], [5], [6]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[4], [5], [6]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[4], [5], [6]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[4], [5], [6]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[4], [5], [6]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[4], [5], [6]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[4], [5], [6]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[4], [5], [6]
D1675		Valerian	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[4], [5], [6]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[4], [5], [6]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[4], [5], [6]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[4], [5], [6]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[4], [5], [6]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[4], [5], [6]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[4], [5], [6]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[4], [5], [6]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[4], [5], [6]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[4], [5], [6]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[4], [5], [6]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[4], [5], [6]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[4], [5], [6]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[4], [5], [6]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[4], [5], [6]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[4], [5], [6]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[4], [5], [6]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[4], [5], [6]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[4], [5], [6]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[4], [5], [6]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[4], [5], [6]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[4], [5], [6]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[4], [5], [6]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[4], [5], [6]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[4], [5], [6]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[4], [5], [6]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[4], [5], [6]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[4], [5], [6]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[4], [5], [6]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[4], [5], [6]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[4], [5], [6]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[4], [5], [6]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[4], [5], [6]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[4], [5], [6]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[4], [5], [6]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[4], [5], [6]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[4], [5], [6]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[4], [5], [6]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[4], [5], [6]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[4], [5], [6]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[4], [5], [6]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[4], [5], [6]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[4], [5], [6]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[4], [5], [6]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[4], [5], [6]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[4], [5], [6]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[2], [8], [9]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[4], [5], [6]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[4], [5], [6]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[4], [5], [6]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[4], [5], [6]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[4], [5], [6]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[4], [5], [6]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[4], [5], [6]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[4], [5], [6]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[4], [5], [6]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[4], [5], [6]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[4], [5], [6]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[4], [5], [6]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[4], [5], [6]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [5], [6]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[4], [5], [6]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[4], [5], [6]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[4], [5], [6]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[4], [5], [6]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[4], [5], [6]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[4], [5], [6]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[2], [8], [9]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[4], [5], [6]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[4], [5], [6]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[4], [5], [6]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[4], [5], [6]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[4], [5], [6]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[4], [5], [6]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[4], [5], [6]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[4], [5], [6]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [5], [6]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[4], [5], [6]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[4], [5], [6]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[4], [5], [6]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[4], [5], [6]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[4], [5], [6]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[4], [5], [6]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[4], [5], [6]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[4], [5], [6]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[2], [8], [9]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[4], [5], [6]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[4], [5], [6]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[4], [5], [6]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[4], [5], [6]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[4], [5], [6]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[4], [5], [6]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[4], [5], [6]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[4], [5], [6]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[4], [5], [6]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[4], [5], [6]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[4], [5], [6]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[4], [5], [6]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[4], [5], [6]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[4], [5], [6]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[4], [5], [6]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[4], [5], [6]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[4], [5], [6]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[4], [5], [6]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[4], [5], [6]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[4], [5], [6]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[4], [5], [6]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[2], [8], [9]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[4], [5], [6]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[4], [5], [6]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[4], [5], [6]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[4], [5], [6]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[4], [5], [6]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[4], [5], [6]
	Additive hypertensive effects					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1], [2], [3]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[1], [2], [3]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [2], [3]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1], [2], [3]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[1], [2], [3]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[1], [2], [3]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[1], [2], [3]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[1], [2], [3]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[1], [2], [3]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[1], [2], [3]
	Additive hypotensive effects					Drug Num: 105
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[4], [6], [7]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[4], [6], [7]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[4], [6], [7]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[4], [6], [7]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[4], [6], [7]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[4], [6], [7]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[4], [6], [7]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[4], [6], [7]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[4], [6], [7]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4], [6], [7]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[4], [6], [7]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[4], [6], [7]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[4], [6], [7]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[4], [6], [7]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[4], [6], [7]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[4], [6], [7]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[4], [6], [7]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[4], [6], [7]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4], [6], [7]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[4], [6], [7]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[4], [6], [7]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[4], [6], [7]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[4], [6], [7]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[4], [6], [7]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[4], [6], [7]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[4], [6], [7]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[4], [6], [7]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[4], [6], [7]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[4], [6], [7]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[4], [6], [7]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[4], [6], [7]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[4], [6], [7]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[4], [6], [7]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[4], [6], [7]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[4], [6], [7]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[4], [6], [7]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [6], [7]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[4], [6], [7]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[4], [6], [7]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[4], [6], [7]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[4], [6], [7]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[4], [6], [7]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[4], [6], [7]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[4], [6], [7]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[4], [6], [7]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[4], [6], [7]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[4], [6], [7]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[4], [6], [7]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[4], [6], [7]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[4], [6], [7]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[4], [6], [7]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[4], [6], [7]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[4], [6], [7]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[4], [6], [7]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[4], [6], [7]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[4], [6], [7]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[4], [6], [7]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[4], [6], [7]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[4], [6], [7]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[4], [6], [7]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[4], [6], [7]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[4], [6], [7]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[4], [6], [7]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[4], [6], [7]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[4], [6], [7]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[4], [6], [7]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[4], [6], [7]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[4], [6], [7]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[4], [6], [7]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[4], [6], [7]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[4], [6], [7]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[4], [6], [7]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4], [6], [7]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[4], [6], [7]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[4], [6], [7]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[4], [6], [7]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[4], [6], [7]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[4], [6], [7]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[4], [6], [7]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[4], [6], [7]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[4], [6], [7]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[4], [6], [7]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[4], [6], [7]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[4], [6], [7]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[4], [6], [7]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[4], [6], [7]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[4], [6], [7]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [6], [7]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[4], [6], [7]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[4], [6], [7]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[4], [6], [7]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[4], [6], [7]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[4], [6], [7]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[4], [6], [7]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[4], [6], [7]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[4], [6], [7]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[4], [6], [7]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[4], [6], [7]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[10], [11], [7]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[4], [6], [7]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[4], [6], [7]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[4], [6], [7]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[4], [6], [7]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[4], [6], [7]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [6], [7]

References
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6	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
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11	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.

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