Details of Drug

Details of Drug

 Drug General Information (ID: D0065)
  Drug Name
Aminosalicylic acid
  Drug Type Small molecule
  Drug Synonymous
4-Aminosalicylic acid; 65-49-6; Aminosalicylic acid; P-AMINOSALICYLIC ACID; Rezipas; Aminopar; Pamisyl; Parasalindon; Ferrosan; Deapasil; Apacil; Parasal; Paser; Paramycin; Gabbropas; Parasalicil; Pasnodia; Osacyl; Aminox; Pasolac; Pasmed; Propasa; Pasalon; Entepas; Pasdium; Pasara; Pamacyl; Pasem; Pasa; 2-Hydroxy-4-aminobenzoic acid; PASK; APAS; Para-Pas; Sanipirol-4; Hellipidyl; Pascorbic; PAS-C; Benzoic acid, 4-amino-2-hydroxy-; PAS (acid); Aminosalicylic Acid Resin Complex; Aminosalicylate Sodium
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  Disease Class 1B10-1B12: Tuberculosis; DD72: Indeterminate colitis
  Therapeutic Class Aminosalicylates
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C7H7NO3
  InChI 1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
  InChIKey WUBBRNOQWQTFEX-UHFFFAOYSA-N
  Canonical SMILES C1=CC(=C(C=C1N)O)C(=O)O
  External Link
Pubchem ID 4649
CAS Number 65-49-6
CHEBI ID 27565
TTD ID D01WJL
INTEDE ID DR1748
VARIDT ID DR01160

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM009  Altered absorption (Unspecific)
BM014  Interference of cell/tissue uptake
BM028  Competitive inhibition of renal tubular secretion
BM050  Increased risk of bleeding
BM055  Increased risk of hepatotoxicity
BM071  Increased risk of methemoglobinemia
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Aminosalicylic acid
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0395
 
Cyanocobalamin
 
C63H88CoN14O14P
 
5311498 
Minor    Inter Info   
[49], [50], [51], [52], [53]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[32]
      Affected excretion pathways
   Competitive inhibition of renal tubular secretion Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0576
 
Entecavir
 
C12H15N5O3
 
135398508 
Moderate    Inter Info   
[29]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[39]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Major    Inter Info   
[1], [2]
   Increased risk of hepatotoxicity Drug Num:  20
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Major    Inter Info   
[3], [4], [5]
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Major    Inter Info   
[6]
D1073
 
Mipomersen
 
C230H324N67O122P19S19
 
118984467 
Major    Inter Info   
[7]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Major    Inter Info   
[11]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Major    Inter Info   
[3], [4], [5]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Moderate    Inter Info   
[22]
D0199
 
Brentuximab vedotin
 
NA
 
NA
Moderate    Inter Info   
[24]
D0248
 
Cannabidiol
 
C21H30O2
 
644019 
Moderate    Inter Info   
[14], [25]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[26]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[27], [28]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[13], [14], [30]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[31]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[14], [33]
D1106
 
Naltrexone
 
C20H23NO4
 
5360515 
Moderate    Inter Info   
[34]
D1239
 
Peginterferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[35], [36], [37], [38]
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[13], [14], [43], [44], [45]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[46], [47]
D1615
 
Trabectedin
 
C39H43N3O11S
 
108150 
Moderate    Inter Info   
[14], [48]
D0826
 
Interferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[35], [36], [37], [38]
D0827
 
Interferon beta-1b
 
NA
 
NA
Moderate    Inter Info   
[35], [36], [37], [38]
   Increased risk of methemoglobinemia Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1148
 
Nitrous acid
 
HNO2
 
24529 
Major    Inter Info   
[8], [9], [10]
D1337
 
Prilocaine
 
C13H20N2O
 
4906 
Major    Inter Info   
[12], [13], [14], [15], [16], [17], [18]
D0163
 
Benzocaine (topical)
 
C9H11NO2
 
2337 
Moderate    Inter Info   
[14], [15], [23]
D0339
 
Cinchocaine (topical)
 
C20H29N3O2
 
3025 
Moderate    Inter Info   
[14], [15], [23]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[14], [15], [23]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[14], [15], [23]
D1835
 
Lidocaine (ophthalmic)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[14], [15], [23]
D0928
 
Lidocaine (topical)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[14], [15], [23]
D1852
 
Oxybuprocaine (ophthalmic)
 
C17H28N2O3
 
4633 
Moderate    Inter Info   
[14], [15], [23]
D1904
 
Tetracaine (ophthalmic)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[14], [15], [23]
D1562
 
Tetracaine (topical)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[14], [15], [23]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[14], [19], [20]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[21]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[40], [41], [42]
References
1 Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
2 Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
3 Canadian Pharmacists Association.
4 EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
5 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
6 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
7 Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
8 Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
9 Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
10 Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
11 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
12 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
13 Cerner Multum, Inc. "Australian Product Information.".
14 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
15 Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
16 Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
17 Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
18 Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
19 UK government "Typhoid.".
20 American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
21 Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
22 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
23 Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
24 Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
25 Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
26 Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
27 Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
28 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
29 Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
30 Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
31 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
32 Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
33 Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
34 Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
35 Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
36 Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
37 Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
38 Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
39 Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
40 Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
41 MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
42 Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
43 European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
44 Gilead Sciences, Inc "About Remdesivir.".
45 US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
46 Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
47 Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
48 Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
49 Halsted CH, McIntyre PA "Intestinal malabsorption caused by aminosalicylic acid therapy." Arch Intern Med 130 (1972): 935-9. [PMID: 5082475]
50 Heinivaara O "Malabsorption of vitamin B112 during treatment with para-aminosalicylic acid: a preliminary report." Acta Med Scand 175 (1964): 469-71. [PMID: 14149652]
51 Levine RA, "Steatorrhea induced by para-aminosalicylic acid." Ann Intern Med 68 (1968): 1265. [PMID: 4871323]
52 Palva IP, Rytkonen U, Slatulkkila M, Palva M "Drug-induced malabsorption of vitamin B12." Scand J Haematol 9 (1972): 5-7. [PMID: 5056480]
53 Product Information. Paser Granules (aminosalicylic acid). Jacobus Pharmaceutical Company, Princeton, NJ.