Details of Drug

Drug General Information (ID: D0052)
Drug Name	Ambenonium
Drug Type	Small molecule
Drug Synonymous	Ambenonum; Ambenonium Base; Ambenonium kation; Mytelase (TN); (2-chlorophenyl)methyl-[2-[[2-[2-[(2-chlorophenyl)methyl-diethylazaniumyl]ethylamino]-2-oxoacetyl]amino]ethyl]-diethylazanium; 2,2'-[(1,2-dioxoethane-1,2-diyl)diimino]bis[n-(2-chlorobenzyl)-n,n-diethylethanaminium] Click to Show/Hide
Disease Class	8C6Y: Myasthenia gravis
Therapeutic Class	Antiarrhythmic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C28H42Cl2N4O2+2
InChI	1S/C28H40Cl2N4O2/c1-5-33(6-2,21-23-13-9-11-15-25(23)29)19-17-31-27(35)28(36)32-18-20-34(7-3,8-4)22-24-14-10-12-16-26(24)30/h9-16H,5-8,17-22H2,1-4H3/p+2
InChIKey	OMHBPUNFVFNHJK-UHFFFAOYSA-P
Canonical SMILES	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl
External Link
	Pubchem ID	2131
	CAS Number	7648-98-8
	CHEBI ID	2627
	TTD ID	D06IAQ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM037 Additive cholinergic effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM081 Increased risk of ventricular arrhythmias BM091 Antagonize the effect of cholinergic agents
Relation Graph

Full list of drugs interacting with Ambenonium
Pharmacodynamic additive effects
	Additive cholinergic effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[5], [6]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[19], [20], [21]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[19], [20], [21]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[19], [20], [21]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[19], [20], [21]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[19], [20], [21]
	Increased risk of bradycardia					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[1], [2]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[3], [4]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[8]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[12], [13], [14]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[15], [16]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[1], [17]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[18]
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[1], [12], [22]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[7]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[9], [10], [11]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[9], [10], [11]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[9], [10], [11]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[9], [10], [11]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[7]
D0759		Homatropine	C16H21NO3	5282593	Moderate		Inter Info	[7]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[7]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[7]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[7]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[9], [10], [11]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[7]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[7]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[9], [10], [11]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[7]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[7]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[7]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[7]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[7]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[7]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[9], [10], [11]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[7]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[7]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[9], [10], [11]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[7]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[9], [10], [11]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[9], [10], [11]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[7]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[7]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[7]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[7]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[7]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[9], [10], [11]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[9], [10], [11]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[7]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[7]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
3	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
4	Product Information. Alecensa (alectinib). Genentech, South San Francisco, CA.
5	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
6	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
7	Product Information. Mestinon (pyridostigmine). ICN Pharmaceuticals Inc, Cost Mesa, CA.
8	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
9	Brunner NG, Namba T, Grob D "Corticosteroids in management of severe, generalized myasthenia gravis." Neurology 22 (1972): 603-10
10	Namba T "Corticotropin therapy in patients with myasthenia gravis." Arch Neurol 26 (1972): 144-50
11	Patten BM, Oliver KL, Engel WK "Adverse interaction between steroid hormones and anticholinesterase drugs." Neurology 24 (1974): 442-9
12	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
14	Canadian Pharmacists Association "e-CPS."
15	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
16	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
17	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
18	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
19	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
20	Product Information. Cognex (tacrine). Parke-Davis, Morris Plains, NJ.
21	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
22	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.

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