Details of Drug

Drug General Information (ID: D0051)
Drug Name	Amantadine
Drug Type	Small molecule
Drug Synonymous	Adamantamine; Adamantanamine; Adamantylamine; Amant; Amantadina; Amantadinum; Amantidine; Aminoadamantane; Endantadine; Mantadine; Symadine; Wiregyt; Amantadine Base; BIA4304; OR14310; Amantadina [INN-Spanish]; Amantadine (INN); Amantadine [INN:BAN]; Amantadinum [INN-Latin]; Gen-Amantadine; Pk-merz; Symmetrel (TN); TCMDC-125869; ADAMANTANE,1-AMINO; Adamantan-1-amine; Adamantan-1-ylamine; Tricyclo[3.3.1.1^3,7]decan-1-amine; Tricyclo(3.3.1.13,7)decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-ylamine; Tricyclo[3.3.1.1(3,7)]decane-1-amine; Tricyclo[3.3.1.1(sup3,7)]decan-1-amine; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine; Tricyclo(3.3.1.1(sup 3.7))decan-1-amine; Tricyclo[3.3.1.1~3,7~]decan-1-amine; Tricyclo(3.3.1.1(3,7))-decan-1-amine; 1-Adamantamine; 1-Adamantanamine; 1-Adamantanamine (8CI); 1-Adamantylamine; 1-Aminoadamantane; 1-Aminotricyclo(3.3.1.1(sup 3,7))decane Click to Show/Hide
Disease Class	1E30-1E32: Influenza
Therapeutic Class	Antiviral Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H17N
InChI	1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
InChIKey	DKNWSYNQZKUICI-UHFFFAOYSA-N
Canonical SMILES	C1C2CC3CC1CC(C2)(C3)N
External Link
	Pubchem ID	2130
	CAS Number	768-94-5
	CHEBI ID	2618
	TTD ID	D02KRS
	INTEDE ID	DR2259
	VARIDT ID	DR00040

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM033 Additive anticholinergic effects BM038 Additive CNS depression effects BM040 Additive dopaminergic effects BM069 Increased risk of lowers seizure threshold BM093 Antagonize the effect of dopaminergic agents
Relation Graph

Full list of drugs interacting with Amantadine
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[20], [18], [40]
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 82
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[12], [13]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[12], [13], [14]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[12], [13]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[12], [13]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[12], [13]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[12], [13]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[12], [13]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[12], [13]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[12], [13]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[12], [13]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[12], [13]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[12], [13]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[12], [13]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[12], [13]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[12], [13]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[12], [13], [14]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[12], [13]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[12], [13], [14]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[12], [13]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[12], [13]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[12], [13]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[12], [13]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[12], [13]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[12], [13], [14]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[12], [13]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[12], [13]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[12], [13]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[12], [13]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[12], [13]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[12], [13]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[12], [13]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[12], [13]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[12], [13], [14]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[12], [13]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[12], [13]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[12], [13]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[12], [13]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[12], [13]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[12], [13]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[12], [13]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[12], [13]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[12], [13]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[12], [13], [14]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[12], [13]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[12], [13]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[12], [13]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[12], [13]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[12], [13]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[12], [13]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[12], [13]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[12], [13]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[12], [13]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[12], [13]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[12], [13]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[12], [13]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[12], [13]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[12], [13]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[12], [13]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[12], [13]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[12], [13]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[12], [13]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[12], [13]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[12], [13]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[12], [13]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[12], [13]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[12], [13]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[12], [13]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[12], [13]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[12], [13]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[12], [13]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[12], [13]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[12], [13]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[12], [13]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[12], [13]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[12], [13]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[12], [13]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[12], [13]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[12], [13]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[12], [13]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[12], [13]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[12], [13]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[12], [13]
	Additive CNS depression effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[17], [18], [19]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[20], [21]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[22]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[31], [14], [32]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[17], [18], [19]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[17], [18], [19]
	Additive dopaminergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[36]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[4], [5], [6], [7], [8]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[4], [5], [6], [7], [8]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[9], [10], [3], [11]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[15], [16]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[34], [35], [18]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[34], [35], [18]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[34], [35], [18]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[37], [38], [39]
Pharmacodynamic antagonistic effects
	Antagonize the effect of dopaminergic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[33], [13]

References
1	Johnston JA, Lineberry CG, Ascher JA, et al. "A 102-center prospective study of seizure in association with bupropion." J Clin Psychiatry 52 (1991): 450-6. [PMID: 1744061]
2	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
3	Rosenstein DL, Nelson JC, Jacobs SC "Seizures associated with antidepressants: a review." J Clin Psychiatry 54 (1993): 289-99. [PMID: 8253696]
4	Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
5	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
6	Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]
7	Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
8	Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
9	Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
10	Pisani F, Spina E, Oteri G "Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice." Epilepsia 40(Suppl 10) (1999): S48-56. [PMID: 10609604]
11	Gardiner JS, Blough D, Drinkard CR, et al. "Tramadol and seizures: a surveillance study in a managed care population." Pharmacotherapy 20 (2000): 1423-31. [PMID: 11130214]
12	Postma JU, van Tilburg W "Visual hallucinations and delirium during treatment with amantadine (Symmetrel)." J Am Geriatr Soc 23 (1975): 212-5. [PMID: 123540]
13	Product Information. Symmetrel (amantadine). DuPont Pharmaceuticals, Wilmington, DE.
14	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
15	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
16	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
17	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
18	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
19	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
20	Cerner Multum, Inc. "Australian Product Information.".
21	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
22	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
23	Kajiyama Y, Fujii K, Takeuchi H, Manabe Y "Ginkgo seed poisoning." Pediatrics 109 (2002): 325-7. [PMID: 11826216]
24	Granger AS "Ginkgo biloba precipitating epileptic seizures." Age Ageing 30 (2001): 523-5. [PMID: 11742783]
25	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
26	Spinella M "Herbal medicines and epilepsy: the potential for benefit and adverse effects." Epilepsy Behav 2 (2001): 524-32. [PMID: 12609386]
27	Gregory PJ "Seizure associated with Ginkgo biloba?." Ann Intern Med 134 (2001): 344. [PMID: 11182853]
28	Harms SL, Garrard J, Schwinghammer P, Eberly LE, Chang Y, Leppik IE "Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder." Epilepsia 47 (2006): 323-9. [PMID: 16499756]
29	Miwa H, Iijima M, Tanaka S, Mizuno Y "Generalized convulsions after consuming a large amount of Gingko nuts." Epilepsia 42 (2001): 280-1. [PMID: 11240603]
30	Kupiec T, Raj V "Fatal seizures due to potential herb-drug interactions with Ginkgo biloba." J Anal Toxicol 29 (2005): 755-8. [PMID: 16419414]
31	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
32	Simonian NA, Gilliam FG, Chiappa KH "Ifosfamide causes a diazepam-sensitive encephalopathy." Neurology 43 (1993): 2700-2
33	Product Information. Reglan (metoclopramide). Wyeth-Ayerst Laboratories, Philadelphia, PA.
34	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
35	Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
36	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.
37	Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
38	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
39	Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
40	Product Information. Bactrim (trimethoprim-sulfamethoxazole). Roche Laboratories, Nutley, NJ.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence