Drug General Information (ID: DDIZSRF07D)
Drug Name			Amiodarone		Drug Info		Oxygen		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Nutritional Supplements
Structure

Mechanism of Amiodarone-Oxygen Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Amiodarone				Oxygen
Mechanism		Amiodarone				Increase the risk of amiodarone-associated adult respiratory distress syndrome
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Amiodarone and Oxygen

Recommended Action
Management		Until more information is available, it is recommended that oxygenation parameters (e.g., Fi02, SaO2, and PaO2) should be closely monitored in amiodarone-treated patients. The risks and benefits of surgery should be evaluated for patients who have preexisting respiratory dysfunction. Some experts recommend the use of the lowest possible concentrations of oxygen to maintain oxygenation.

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Libersa CC, Brique SA, Motte KB, et al. "Dramatic inhibition of amiodarone metabolism induced by grapefruit juice." Br J Clin Pharmacol 49 (2000): 373-8. [PMID: 10759694]