Drug General Information (ID: DDIZSPEFA2)
  Drug Name Metaraminol Drug Info Maprotiline Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Antidepressants
  Structure

 Mechanism of Metaraminol-Maprotiline Interaction (Severity Level: Minor)
     Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Metaraminol Maprotiline
      Mechanism Sympathomimetic amine Blunt the pressor effect of some sympathomimetics
      Key Mechanism Factor 1
Factor Name Pharmacodynamics
Factor Description Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
      Mechanism Description
  • Attenuated pharmacological effects of  Metaraminol when combined with Maprotiline 

References
1 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
3 Briant RH, George CF "The assessment of potential drug interactions with a new tricyclic antidepressant drug." Br J Clin Pharmacol 1 (1974): 113-8