Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIZQ9XKEJ)
  Drug Name Succinylcholine Drug Info Vecuronium Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Analgesics
  Structure

 Mechanism of Succinylcholine-Vecuronium Interaction (Severity Level: Moderate)
     Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Succinylcholine Vecuronium
      Mechanism Neuromuscular blocking agent
Acetylcholinesterase  Substrate 		Neuromuscular blocking agent
Neuronal acetylcholine receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Acetylcholinesterase
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Structure Sequence
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
Gene Name ACHE
Uniprot ID ACES_HUMAN
KEGG Pathway hsa:43
Protein Family Type-B carboxylesterase/lipase family
Protein Function
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.
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      Key Mechanism Factor 2
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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      Mechanism Description
  • Additive neuromuscular blocking effects by the combination of Succinylcholine and Vecuronium 

Recommended Action
      Management Excessive neuromuscular blockade may be anticipated if these agents are coadministered and patients should be closely monitored.

References
1 Product Information. Norcuron (vecuronium). Organon, West Orange, NJ.
2 Shanks AB, Long T, Aitkenhead AR "Prolonged neuromuscular blockade following vecuronium. A case report." Br J Anaesth 57 (1985): 807-10
3 Nishizawa M, Goto H, Otagiri T, Nakajima K, Harashima N, Sakaki J "Effect of prior administration of succinylcholine on duration of action of vecuronium during enflurane anaesthesia." Acta Anaesthesiol Scand 38 (1994): 380-3