Drug General Information (ID: DDIZQ5G6CV)
Drug Name			Meclofenamic acid		Drug Info		Potassium citrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Minerals And Electrolytes
Structure

Mechanism of Meclofenamic acid-Potassium citrate Interaction (Severity Level: Moderate)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Meclofenamic acid				Potassium citrate
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Meclofenamic acid and Potassium citrate

Recommended Action
Management		Closely monitor potassium levels in patients receiving both potassium salts and NSAID therapy, especially those with renal impairment, diabetes, older age, severe or worsening heart failure, dehydration, or concomitant therapy with other agents that increase serum potassium (e.g., beta-blockers, cyclosporine, heparin, tacrolimus, and trimethoprim). Patients should be advised to seek medical attention if they experience signs and symptoms of hyperkalemia such as nausea, vomiting, weakness, listlessness, tingling of the extremities, paralysis, confusion, weak pulse, and a slow or irregular heartbeat.

References
1	Product Information. K-Phos Original (potassium acid phosphate). Beach Pharmaceuticals, Tampa, FL.
2	Product Information. Potassium Chloride ER (potassium chloride). Zydus Pharmaceuticals (USA) Inc, Princeton, NJ.
3	Cerner Multum, Inc. "Australian Product Information.".