Drug General Information (ID: DDIZQ264PX)
Drug Name			Tacrolimus		Drug Info		Valganciclovir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Immunosuppressive Agents				Antiviral Agents
Structure

Mechanism of Tacrolimus-Valganciclovir Interaction (Severity Level: Moderate)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Tacrolimus				Valganciclovir
Mechanism 1		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Tacrolimus and Valganciclovir
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Tacrolimus				Valganciclovir
Mechanism 2		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 2
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Tacrolimus and Valganciclovir

Recommended Action
Management		Some authorities advise that these medicines should be coadministered only if the benefits are anticipated to outweigh the potential risks. If concomitant use is required, close clinical and laboratory monitoring of renal and neurologic function and drug serum concentrations (if clinically appropriate) as well as for the development of severe hematologic adverse effects is recommended.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".