Drug General Information (ID: DDIZNJUFL1)
  Drug Name Mycophenolate mofetil Drug Info Azathioprine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Immunosuppressive Agents Immunosuppressive Agents
  Structure

 Mechanism of Mycophenolate mofetil-Azathioprine Interaction (Severity Level: Moderate)
     Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Mycophenolate mofetil Azathioprine
      Mechanism 1 Immunosuppressive effects Immunosuppressive effects
      Key Mechanism Factor 1
Factor Name Immunosuppressive effects
Factor Description Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
      Mechanism Description
  • Additive immunosuppressive effects by the combination of Mycophenolate mofetil and Azathioprine 
     Additive myelosuppressive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Mycophenolate mofetil Azathioprine
      Mechanism 2 Myelosuppressive effects Myelosuppressive effects
      Key Mechanism Factor 2
Factor Name Myelosuppressive effects
Factor Description Myelosuppression, also known as bone marrow suppression, is a decrease in bone marrow activity that leads to a decrease in the production of blood cells. Some blood cell disorders include: erythrocytopenia (anemia), leukopenia (neutropenia), and thrombocytopenia (thrombocytopenia).
      Mechanism Description
  • Additive myelosuppressive effects by the combination of Mycophenolate mofetil and Azathioprine 

Recommended Action
      Management Due to their similar mechanism of action, concomitant administration of mycophenolic acid and azathioprine is not recommended.

References
1 Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.