Drug General Information (ID: DDIZG3JITW)
Drug Name			Primidone		Drug Info		Levoleucovorin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Folate Supplements
Structure

Mechanism of Primidone-Levoleucovorin Interaction (Severity Level: Moderate)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Primidone				Levoleucovorin
Mechanism		Antiepileptic agent				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Primidone when combined with Levoleucovorin

Recommended Action
Management		Caution is advised when folate therapy is coadministered with anticonvulsants. Close monitoring for clinical and laboratory evidence of diminished therapeutic response to both treatments is recommended. Patients should be advised to notify their physician if they experience loss of seizure control.

References
1	Berg MJ, Fischer LJ, Rivey MP, Vern BA, Lantz RK, Schottelius DD "Phenytoin and folic acid interaction: a preliminary report." Ther Drug Monit 5 (1983): 389-94. [PMID: 6659012]
2	Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095. [PMID: 4742232]
3	Furlanut M, Benetello P, Avogaro A, Dainese R "Effects of folic acid on phenytoin kinetics in healthy subjects." Clin Pharmacol Ther 24 (1978): 294-7. [PMID: 688723]