Drug General Information (ID: DDIZCLFV0O)
Drug Name			Valproic acid		Drug Info		Phenylacetic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Antihyperammonia Agents
Structure

Mechanism of Valproic acid-Phenylacetic acid Interaction (Severity Level: Major)
Antagonize the effect of anti-hyperammonemia agents Click to Show/Hide Mechanism Graph
Drug Name		Valproic acid				Phenylacetic acid
Mechanism		Hyperammonemia				Anti-hyperammonemia agent
Key Mechanism Factor 1
		Factor Name		Anti-hyperammonemia agents
		Factor Description		Anti-hyperammonemic agents may be less effective in acute hyperammonemia, leading to the development of hyperammonemic encephalopathy, which can sometimes be fatal.
Mechanism Description		Antagonize the effect of Valproic acid when combined with Phenylacetic acid

Recommended Action
Management		The use of valproic acid is contraindicated in patients with known urea cycle disorders.

References
1	Product Information. Ammonul (sodium benzoate-sodium phenylacetate). Ucyclyd Pharma, Scottsdale, AZ.
2	Product Information. Depakene (valproic acid). Abbott Pharmaceutical, Abbott Park, IL.
3	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.