Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIZ64H5FV)
  Drug Name Colistimethate Drug Info Doxacurium Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antibiotics Analgesics
  Structure

 Mechanism of Colistimethate-Doxacurium Interaction (Severity Level: Major)
     Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Colistimethate Doxacurium
      Mechanism Neuromuscular blocking effects Neuromuscular blocking agent
Neuronal acetylcholine receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Click to Show/Hide
      Mechanism Description
  • Additive neuromuscular blocking effects by the combination of Colistimethate and Doxacurium 

Recommended Action
      Management Patients should be closely monitored for prolonged neuromuscular blockade. Intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases.

References
1 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2 Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
3 Cerner Multum, Inc. "Australian Product Information.".
4 Cerner Multum, Inc. "Canadian Product Information.".
5 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6 Huang KC, Heise A, Shrader AK, Tsueda K "Vancomycin enhances the neuromuscular blockade of vecuronium." Anesth Analg 71 (1990): 194-6. [PMID: 1973882]
7 Kronenfeld MA, Thomas SJ, Turndorf H "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology 65 (1986): 93-4. [PMID: 2873764]
8 Product Information. Coly-Mycin M Parenteral (colistimethate). Parke-Davis, Morris Plains, NJ.
9 Product Information. Rocuronium Bromide (rocuronium). Hospira Inc, Lake Forest, IL.
10 Product Information. Vecuronium Bromide (vecuronium). Hospira Inc, Lake Forest, IL.