Details of Drug Interaction | MecDDI

Drug General Information (ID: DDIZ2P68FH)
Drug Name			Triamterene		Drug Info		Apomorphine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Triamterene-Apomorphine Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph

Drug Name		Triamterene				Apomorphine
Mechanism 1		Antihypertensive agent Amiloride-sensitive sodium channel Blocker				Antihypertensive agent
Key Mechanism Factor 1
		Factor Name		Amiloride-sensitive sodium channel				Structure Sequence
		Protein Family		Amiloride-sensitive sodium channel (TC 1.A.6) family
		Protein Function		Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Triamterene and Apomorphine
Mechanism 2		Antihypertensive agent Amiloride-sensitive sodium channel Blocker				Hypotensive effects
Key Mechanism Factor 2
		Factor Name		Amiloride-sensitive sodium channel				Structure Sequence
		Protein Family		Amiloride-sensitive sodium channel (TC 1.A.6) family
		Protein Function		Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Triamterene and Apomorphine

Recommended Action
Management		Caution and close monitoring for altered efficacy and safety are recommended if patients receive apomorphine with an antihypertensive agent or vasodilator. Patients should be made aware of the possible side effects (e.g., dizziness, lightheadedness, orthostasis) and be cautioned about driving, operating machinery, or performing other hazardous tasks. They should also be advised to avoid rising abruptly from a sitting or recumbent position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.

References
1	Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
2	Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
3	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.