Drug General Information (ID: DDIYE5UJ3R)
  Drug Name Desmopressin Drug Info Felbamate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidiuretic Hormones Anticonvulsants
  Structure

 Mechanism of Desmopressin-Felbamate Interaction (Severity Level: Moderate)
     Increased risk of hyponatremia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Desmopressin Felbamate
      Mechanism Hyponatremia Hyponatremia
      Key Mechanism Factor 1
Factor Name Hyponatremia
Factor Description Hyponatremia is a condition in which the amount of sodium in the blood is lower than normal. Symptoms of hyponatremia may include: nausea and vomiting, fatigue, headache or confusion, muscle cramps, weakness, irritability and restlessness.
      Mechanism Description
  • Increased risk of hyponatremia by the combination of Desmopressin and Felbamate 

Recommended Action
      Management Caution is advised when vasopressin or desmopressin is used in combination with drugs that can cause fluid retention or SIADH. Some authorities recommend adjusting vasopressin dosage as needed. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated therefore, early treatment is important to help prevent progression to seizures, coma, respiratory arrest, and death.

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