Drug General Information (ID: DDIYCUW3VH)
Drug Name			Triamterene		Drug Info		Lithium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Antimanic Agents
Structure

Mechanism of Triamterene-Lithium carbonate Interaction (Severity Level: Major)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Triamterene				Lithium carbonate
Mechanism		Reduced renal clearance of lithium				Lithium salt
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Lithium carbonate caused by Triamterene

Recommended Action
Management		Concurrent use of diuretics and lithium should generally be avoided. Extreme caution is recommended if they must be used together. Lithium levels should be monitored daily and lithium dose reductions may be required. Patients should be advised to notify their physician if they experience drowsiness, dizziness, weakness, ataxia, vomiting, diarrhea, tinnitus,tremor, thirst, blurry vision, or increased urination.

References
1	Product Information. Aldactone (spironolactone). Searle, Skokie, IL.
2	Product Information. Eskalith (lithium). SmithKline Beecham, Philadelphia, PA.
3	Vipond AJ, Bakewell S, Telford R, Nicholls AJ "Lithium toxicity." Anaesthesia 51 (1996): 1156-8. [PMID: 9038456]