Drug General Information (ID: DDIYA20E4D)
  Drug Name Acetohexamide Drug Info Lactic acid Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidiabetic Agents Topical Agents
  Structure

 Mechanism of Acetohexamide-Lactic acid Interaction (Severity Level: Minor)
     Altered urine pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Acetohexamide Lactic acid
      Mechanism Urine pH sensitive Urine alkalinizer
      Key Mechanism Factor 1
Factor Name Urine pH
Factor Description The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
      Mechanism Description
  • Altered elimination of Acetohexamide caused by Lactic acid mediated altered urine pH

References
1 Kivisto KT, Neuvonen PJ "Differential effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide." Eur J Clin Pharmacol 40 (1991): 383-6. [PMID: 1646724]
2 Neuvonen PJ, Karkkainen S "Effects of charcoal, sodium bicarbonate, and ammonium chloride on chlorpropamide kinetics." Clin Pharmacol Ther 33 (1983): 386-93. [PMID: 6297841]
3 Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]