| Mechanism of Doxepin (topical)-Vilanterol Interaction
(Severity Level: Moderate)
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Additive hypertensive effects
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| Drug Name |
Doxepin (topical) |
Vilanterol |
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Mechanism 1
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Hypertensive effects |
Hypertensive effects |
| Key Mechanism Factor 1 |
| Factor Name |
Hypertensive effects |
| Factor Description |
Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head. |
| Mechanism Description |
- Additive hypertensive effects by the combination of Doxepin (topical) and Vilanterol
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Increased risk of ventricular arrhythmias
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| Drug Name |
Doxepin (topical) |
Vilanterol |
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Mechanism 2
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Cardiac arrhythmias |
Cardiac arrhythmias |
| Key Mechanism Factor 2 |
| Factor Name |
Ventricular arrhythmias |
| Factor Description |
Ventricular arrhythmias are abnormal heart rhythms that cause your heart's lower chambers to pump blood instead of pumping it. This can limit or stop your heart from supplying blood to your body. While some of these arrhythmias are harmless and do not cause symptoms, others can have serious, even fatal, effects on your body. |
| Mechanism Description |
- Increased risk of ventricular arrhythmias by the combination of Doxepin (topical) and Vilanterol
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