Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIXTA7KD9)
  Drug Name Nortriptyline Drug Info Isoflurane Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidepressants Anesthetics
  Structure

 Mechanism of Nortriptyline-Isoflurane Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nortriptyline Isoflurane
      Mechanism 1 Antihypertensive agent Antihypertensive agent
      Key Mechanism Factor 1
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Nortriptyline and Isoflurane 
      Mechanism 2 Hypotensive effects Antihypertensive agent
      Key Mechanism Factor 2
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Nortriptyline and Isoflurane 
      Mechanism 3 Antihypertensive agent Hypotensive effects
      Key Mechanism Factor 3
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Nortriptyline and Isoflurane 
      Mechanism 4 Hypotensive effects Hypotensive effects
      Key Mechanism Factor 4
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Nortriptyline and Isoflurane 
     Increased risk of ventricular arrhythmias Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nortriptyline Isoflurane
      Mechanism 5 Cardiac arrhythmias Cardiac arrhythmias
      Key Mechanism Factor 5
Factor Name Ventricular arrhythmias
Factor Description Ventricular arrhythmias are abnormal heart rhythms that cause your heart's lower chambers to pump blood instead of pumping it. This can limit or stop your heart from supplying blood to your body. While some of these arrhythmias are harmless and do not cause symptoms, others can have serious, even fatal, effects on your body.
      Mechanism Description
  • Increased risk of ventricular arrhythmias by the combination of Nortriptyline and Isoflurane 

Recommended Action
      Management Close monitoring is recommended when these drugs are used together.

References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".