Drug General Information (ID: DDIXSK041E)
Drug Name			Nicardipine		Drug Info		Vecuronium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Analgesics
Structure

Mechanism of Nicardipine-Vecuronium Interaction (Severity Level: Moderate)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Nicardipine				Vecuronium
Mechanism		Reduce the renal excretion of vecuronium				Vecuronium
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Vecuronium caused by Nicardipine

Recommended Action
Management		Patients should be monitored for excessive and prolonged neuromuscular blockade. One study concluded that a clinical dose of nicardipine reduces vecuronium dosage requirements by as much as 53%.

References
1	Bailey DG, Kreeft JH, Munoz C, Freeman DJ, Bend JR "Grapefruit juice felodipine interaction: Effect of naringin and 6',7'-dihydroxybergamottin in humans." Clin Pharmacol Ther 64 (1998): 248-56. [PMID: 9757148]
2	Grapefruit juice interactions with drugs. Med Lett Drugs Ther 37 (1995): 73-4. [PMID: 7630329]
3	Kawabata K, Sumikawa K, Kamibayashi T, et al "Decrease in vecuronium infusion dose requirements by nicardipine in humans." Anesth Analg 79 (1994): 1159-64