Details of Drug-Drug Interaction
| Drug General Information (ID: DDIXHPG7BW) | |||||||||
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| Drug Name | Ertapenem | Drug Info | Valproic acid | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antibiotics | Anticonvulsants | |||||||
| Structure | |||||||||
| Mechanism of Ertapenem-Valproic acid Interaction (Severity Level: Major) | |||||||||
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| Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ertapenem | Valproic acid | |||||||
| Mechanism | Lower seizure threshold | Antiepileptic agent | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Antiepileptic agents | ||||||||
| Factor Description | The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Concomitant use of valproic acid with carbapenem antibiotics is generally not recommended. Use of alternative antibiotics should be considered in patients whose seizures are well controlled on valproic acid therapy. If coadministration is required, supplemental anticonvulsant therapy may be advisable, since increasing the valproic acid dose alone may not be sufficient to overcome the interaction. Nevertheless, pharmacologic response and serum valproate levels should be monitored closely following the addition or withdrawal of carbapenem treatment, and the dosage adjusted as necessary. | ||||||||