Drug General Information (ID: DDIXE09IM2)
Drug Name			Nalidixic acid		Drug Info		Bupropion		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antidepressants
Structure

Mechanism of Nalidixic acid-Bupropion Interaction (Severity Level: Major)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Nalidixic acid				Bupropion
Mechanism		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Nalidixic acid and Bupropion

Recommended Action
Management		Extreme caution is advised if bupropion is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with a history of seizures or other risk factors for seizures (e.g., head trauma brain tumor severe hepatic cirrhosis metabolic disorders CNS infections excessive use of alcohol or sedatives addiction to opiates, cocaine, or stimulants diabetes treated with oral hypoglycemic agents or insulin). Bupropion as well as concomitant medications should be initiated at the lower end of the dosage range and titrated gradually as needed and as tolerated. The maximum recommended dosage for the specific bupropion formulation should not be exceeded. Bupropion should be discontinued and not restarted in patients who experience a seizure during treatment.

References
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