Drug General Information (ID: DDIXD98C40)
Drug Name			Coccidioides immitis spherule		Drug Info		Avapritinib		Drug Info
Drug Type		Allergenics				Small molecule
Therapeutic Class		Allergy Test				Multikinase Inhibitors

Mechanism of Coccidioides immitis spherule-Avapritinib Interaction (Severity Level: Moderate)
Diminish the response to diagnostic skin test antigens Click to Show/Hide Mechanism Graph
Drug Name		Coccidioides immitis spherule				Avapritinib
Mechanism		Diagnostic skin test antigens				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Diagnostic skin test antigens
		Factor Description		The efficacy of diagnostic skin test antigens may be reduced, leading to falsely insignificant or false-negative results may occur in such patients.
Mechanism Description		Reduced reactions to diagnostic skin test antigens for Coccidioides immitis spherule when combined with Avapritinib

Recommended Action
Management		Clinicians should be aware of the potential for falsely insignificant or false-negative results when administering diagnostic skin test antigens to patients treated with immunosuppressive agents.

References
1	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
2	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
3	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.