Drug General Information (ID: DDIX7Y6H4R)
Drug Name			Cyclosporine		Drug Info		Metoclopramide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antiemetics
Structure

Mechanism of Cyclosporine-Metoclopramide Interaction (Severity Level: Moderate)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Metoclopramide
Mechanism		Absorption is influenced by gastrointestinal motility				Increase gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Cyclosporine due to GI dynamics variation caused by Metoclopramide

Recommended Action
Management		Cyclosporine levels and renal function, including serum creatinine, should be carefully monitored, during concurrent therapy. Cyclosporine dosage should be adjusted as needed. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References
1	Greiff JMC, Rowbotham D "Pharmacokinetic drug interactions with gastrointestinal motility modifying agents." Clin Pharmacokinet 27 (1994): 447-61. [PMID: 7882635]
2	Morse GD, Holdsworth MT, Venuto RC, Gerbasi J, Walshe JJ "Pharmacokinetics and clinical tolerance of intravenous and oral cyclosporine in the immediate postoperative period." Clin Pharmacol Ther 44 (1988): 654-64. [PMID: 3058372]
3	Product Information. Sandimmune (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
4	Wadhwa NK, Schroeder TJ, O'Flaherty E, Pesce AJ, Myre SA, First MR "The effect of oral metoclopramide on the absorption of cyclosporine." Transplantation 43 (1987): 211-3. [PMID: 3544377]
5	Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (part II)." Clin Pharmacokinet 19 (1990): 400-15. [PMID: 2268987]