Drug General Information (ID: DDIWVQR0PC)
Drug Name			Sevoflurane		Drug Info		Aloe Vera Leaf		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Anesthetics				Herbal Products
Structure

Mechanism of Sevoflurane-Aloe Vera Leaf Interaction (Severity Level: Moderate)
Increased risk of bleeding Click to Show/Hide Mechanism Graph
Drug Name		Sevoflurane				Aloe Vera Leaf
Mechanism		Risk of bleeding Antiplatelet/anticoagulant effects				Risk of bleeding Antiplatelet effects
Key Mechanism Factor 1
		Factor Name		Bleeding
		Factor Description		Patients may be at risk for bleeding when the outcome of a disease or disease treatment confounds the standard mechanisms for maintaining hemostasis. Signs or symptoms of abnormal bleeding include: bleeding that takes a long time to stop (including nosebleeds, bleeding gums, bleeding from cuts and abrasions, and menstrual bleeding); severe unexplained bruising, or bruising that becomes larger; blood in the urine or stool, etc.
Mechanism Description		Increased risk of bleeding by the combination of Sevoflurane and Aloe Vera Leaf

Recommended Action
Management		Patients should consult a healthcare provider before taking any herbal or alternative medicine. Until more data are available, consumption of aloe vera should preferably be avoided approximately 2 weeks prior to surgery. In patients who have used this herb extensively before surgery, the potential for an interaction with sevoflurane should be considered, and substitution with isoflurane may be appropriate if bleeding is a concern.

References
1	Lee A, Chui PT, Aun CS, Gin T, Lau AS "Possible interaction between sevoflurane and Aloe vera." Ann Pharmacother 38 (2004): 1651-4. [PMID: 15292490]