Drug General Information (ID: DDIWTRZPOY)
Drug Name			Acetazolamide		Drug Info		Lithium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Antimanic Agents
Structure

Mechanism of Acetazolamide-Lithium carbonate Interaction (Severity Level: Minor)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Acetazolamide				Lithium carbonate
Mechanism		Urine alkalinizer				Urine pH sensitive
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Lithium carbonate caused by Acetazolamide mediated altered urine pH

References
1	Davidson SI "Drug interactions in ophthalmology." Trans Ophthalmol Soc U K 95 (1975): 277-80. [PMID: 1064225]
2	Horowitz LC, Fisher GU "Acute lithium toxicity." N Engl J Med 281 (1970): 1369. [PMID: 5355447]
3	Keogh A, Esmore D, Spratt P, Savdie E, McCluskey P, Chang V "Acetazolamide and cyclosporine." Transplantation 46 (1988): 478-9. [PMID: 3047945]