Drug General Information (ID: DDIW7BX2SI)
Drug Name			Cyclosporine		Drug Info		Triamterene		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Diuretics
Structure

Mechanism of Cyclosporine-Triamterene Interaction (Severity Level: Moderate)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Triamterene
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Cyclosporine and Triamterene

Recommended Action
Management		The concomitant use of potassium-sparing diuretics and cyclosporine should be avoided. A different class of antihypertensive should be considered.

References
1	Marcy TR, Ripley TL "Aldosterone antagonists in the treatment of heart failure." Am J Health Syst Pharm 63 (2006): 49-58. [PMID: 16373465]
2	Product Information. Neoral Oral Solution (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
3	Product Information. Neoral Soft Gelatin Capsules (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
4	Perazella MA "Drug-induced hyperkalemia: old culprits and new offenders." Am J Med 109 (2000): 307-14. [PMID: 10996582]