Drug General Information (ID: DDIW75ZV9E)
Drug Name			Methadone		Drug Info		Monopotassium phosphate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Minerals And Electrolytes
Structure

Mechanism of Methadone-Monopotassium phosphate Interaction (Severity Level: Minor)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Methadone				Monopotassium phosphate
Mechanism		Urine pH sensitive				Urine acidifier Increase the renal excretion
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Methadone caused by Monopotassium phosphate mediated altered urine pH

References
1	Benmebarek M, Devaud C, Gex-Fabry M, et al. "Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone." Clin Pharmacol Ther 76 (2004): 55-63
2	Nilsson M-I, Widerlov E, Meresaar U, Anggard E "Effect of urinary pH on the disposition of methadone in man." Eur J Clin Pharmacol 22 (1982): 337-42
3	Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32