Drug General Information (ID: DDIVYAG5JD)
Drug Name			Orlistat		Drug Info		Amiodarone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiobesity Agents				Antiarrhythmic Agents
Structure

Mechanism of Orlistat-Amiodarone Interaction (Severity Level: Moderate)
Altered Fat-soluble drugs absorption Click to Show/Hide Mechanism Graph
Drug Name		Orlistat				Amiodarone
Mechanism		Decrease fat-soluble agent absorption				Fat-soluble agent
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased absorption of Amiodarone caused by Orlistat

Recommended Action
Management		Caution is advised when amiodarone is used with orlistat. The possibility of diminished therapeutic effects of amiodarone should be considered. Patients should be monitored more closely following the addition or withdrawal of orlistat, and the amiodarone dosage adjusted as needed.

References
1	Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.
2	Zhi J, Moore R, Kanitra L, Mulligan TE "Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin) in healthy volunteers." J Clin Pharmacol 43 (2003): 428-35. [PMID: 12723464]