Details of Drug-Drug Interaction
| Drug General Information (ID: DDIVUZF1NR) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Propranolol | Drug Info | Ethinylestradiol | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antianxiety Agents | Estrogens | |||||||
| Structure | |||||||||
| Mechanism of Propranolol-Ethinylestradiol Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interference with first-pass metabolism Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Propranolol | Ethinylestradiol | |||||||
| Mechanism | Extensive first-pass metabolism | Interference with first pass metabolism | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | First-pass metabolism | ||||||||
| Factor Description | First-pass metabolism is a drug metabolism phenomenon in which the concentration of a drug, especially when administered orally, is greatly reduced before it reaches the systemic circulation. Interfering with the first-pass metabolism of a drug may affect the total amount of drug reaching the systemic circulation. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Pharmacologic effects including blood pressure and heart rate changes should be monitored more closely when metoprolol, oxprenolol, and propranolol are coadministered with ethinyl estradiol oral contraceptives, and dosage adjustments made as necessary. | ||||||||