Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIVREC7WO)
  Drug Name Sotalol Drug Info Doxacurium Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiarrhythmic Agents Analgesics
  Structure

 Mechanism of Sotalol-Doxacurium Interaction (Severity Level: Moderate)
     Additive cardiorespiratory depression effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Sotalol Doxacurium
      Mechanism 1 Cardiorespiratory depression effects Cardiorespiratory depression effects
      Key Mechanism Factor 1
Factor Name Cardiorespiratory depression effects
Factor Description Cardiorespiratory depression is a reduction or inhibition of the normal function of the heart and lungs. The heart and lungs are the most important organs of the body's circulatory system, and when excessively depressed may result in decreased heart rate, decreased blood pressure, heart failure, slowed breathing (little to no visible chest movement), apnea, narrowed or pinpoint pupils, and seizures.
      Mechanism Description
  • Additive cardiorespiratory depression effects by the combination of Sotalol and Doxacurium 
     Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Sotalol Doxacurium
      Mechanism 2 Potentiates neuromuscular blockade Neuromuscular blocking agent
Neuronal acetylcholine receptor  Antagonist
      Key Mechanism Factor 2
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Click to Show/Hide
      Mechanism Description
  • Additive neuromuscular blocking effects by the combination of Sotalol and Doxacurium 

Recommended Action
      Management Clinicians should recognize the potential for altered effects of neuromuscular blocking agents in the presence of beta-blockers. Respiratory and cardiovascular status should be closely monitored.

References
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5 Loan PB, Connolly FM, Mirakhur RK, Kumar N, Farling P "Neuromuscular effects of rocuronium in patients receiving beta-adrenoreceptor blocking, calcium entry blocking and anticonvulsant drugs." Br J Anaesth 78 (1997): 90-1. [PMID: 9059213]
6 Murthy VS, Patel KD, Elangovan RG, Hwang TF, Solochek SM, Steck JD, Laddu AR "Cardiovascular and neuromuscular effects of esmolol during induction of anesthesia." J Clin Pharmacol 26 (1986): 351-7. [PMID: 2871054]
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8 Yate B, Mostafa SM "Drug interaction?" Anaesthesia 39 (1984): 728-9.