Drug General Information (ID: DDIVJIWBX6)
Drug Name			Polymyxin B		Drug Info		Vibrio cholerae CVD 103-HgR strain live antigen (live)		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antibiotics				Vaccines

Mechanism of Polymyxin B-Vibrio cholerae CVD 103-HgR strain live antigen (live) Interaction (Severity Level: Major)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Polymyxin B				Vibrio cholerae CVD 103-HgR strain live antigen (live)
Mechanism		Impairs immunomodulatory bacterial infective agent				Immunomodulatory infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Vibrio cholerae CVD 103-HgR strain live antigen (live) when combined with Polymyxin B

Recommended Action
Management		Live, attenuated cholera vaccine should not be administered during or for at least 14 days after treatment with systemic antibiotics.

References
1	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.