Drug General Information (ID: DDIVAZQDHN)
Drug Name			Activated charcoal		Drug Info		Ipecac		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidotes				Emetic Agents

Mechanism of Activated charcoal-Ipecac Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Activated charcoal				Ipecac
Mechanism		Activated charcoal				Adsorbed by activated charcoal
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Ipecac due to adsorption of Activated charcoal

Recommended Action
Management		Ipecac and activated charcoal are generally not administered together routinely although the prior administration of one agent should not be considered a contraindication to the administration of the other agent if it is deemed necessary by the attending physician. If both agents are used to treat a patient, the ipecac is generally given first and the charcoal is given after vomiting has stopped.

References
1	Bond GR "The role of activated charcoal and gastric emptying in gastrointestinal decontamination: A state-of-the-art review." Ann Emerg Med 39 (2002): 273-86. [PMID: 11867980]
2	Chyka PA, Seger D "Position statement: single-dose activated charcoal. American Academy of Clinical Toxicology European Association of Poisons Centres an Clinical Toxicologists." J Toxicol Clin Toxicol 35 (1997): 721-41. [PMID: 9482427]
3	Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):.
4	Krenzelok EP, McGuigan M, Lheur P "Position statement: ipecac syrup. American Academy of Clinical Toxicology European Association of Poisons Centres and Clinica Toxicologists." J Toxicol Clin Toxicol 35 (1997): 699-709. [PMID: 9482425]