Drug General Information (ID: DDIV2KTPQU)
Drug Name			Mepenzolate		Drug Info		Tapentadol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Parasympatholytics				Narcotic Analgesics
Structure

Mechanism of Mepenzolate-Tapentadol Interaction (Severity Level: Moderate)
Additive antimotility effects Click to Show/Hide Mechanism Graph
Drug Name		Mepenzolate				Tapentadol
Mechanism 1		Decrease gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Antimotility effects
		Factor Description		Antimotility drugs reduce bowel movements and increase contractions of intestinal segments for treatment of acute diarrhea. Excessive inhibition of intestinal motility can cause bloating and flatulence, increase abdominal cramps, and cause constipation at various times after treatment.
Mechanism Description		Additive antimotility effects by the combination of Mepenzolate and Tapentadol
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Mepenzolate				Tapentadol
Mechanism 2		CNS depression effects				CNS depression effects
Key Mechanism Factor 2
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Mepenzolate and Tapentadol

Recommended Action
Management		Caution and close monitoring of central nervous system, gastrointestinal, and genitourinary adverse effects are recommended when opioids are used with anticholinergic agents. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination.

References
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3	Product Information. Exalgo (hydromorphone). Covidien, Mansfield, MA.
4	Product Information. Kadian (morphine). Zeneca Pharmaceuticals, Wilmington, DE.
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6	Product Information. DepoDur (morphine liposomal). Endo Laboratories LLC, Chadds Ford, PA.
7	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
8	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
9	Product Information. Tylenol with Codeine (acetaminophen-codeine). Janssen Pharmaceuticals, Raritan, NJ.
10	Product Information. Opana (oxymorphone). Endo Laboratories LLC, Chadds Ford, PA.
11	Product Information. Demerol (meperidine). Sanofi Winthrop Pharmaceuticals, New York, NY.
12	Product Information. Levorphanol Tartrate (levorphanol). Sentynl Therapeutics, Solana Beach, CA.
13	Product Information. Belbuca (buprenorphine). Endo Pharmaceuticals Solutions Inc, Malvern, PA.
14	Product Information. SUFentanil Citrate (SUFentanil). Akorn Inc, Buffalo Grove, IL.
15	Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
16	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
17	Product Information. Dolophine (methadone). Lilly, Eli and Company, Indianapolis, IN.
18	Product Information. Alfentanil Hydrochloride (alfentanil). Akorn Inc, Buffalo Grove, IL.
19	Cerner Multum, Inc. "UK Summary of Product Characteristics.".