Drug General Information (ID: DDIUPR9GMY)
Drug Name			Acetazolamide		Drug Info		Triazolam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Acetazolamide-Triazolam Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Acetazolamide				Triazolam
Mechanism		Carbonic anhydrase inhibitor				Counteract the beneficial effects of carbonic anhydrase inhibitor by inhibiting respiratory responses to hypoxia
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Acetazolamide when combined with Triazolam

Recommended Action
Management		Caution is recommended if a CAI and a benzodiazepine must be used together. Until more information is available, it may be prudent to avoid the concurrent use of triazolam and acetazolamide at extreme altitudes.

References
1	Hukkinen SK, Varhe A, Olkkola KT, Neuvonen PJ "Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice." Clin Pharmacol Ther 58 (1995): 127-31. [PMID: 7648762]
2	Kupferschmidt HHT, Ha HR, Ziegler WH, Meier PJ, Krahenbuhl S "Interaction between grapefruit juice and midazolam in humans." Clin Pharmacol Ther 58 (1995): 20-8. [PMID: 7628179]
3	Masuyama S, Hirata K, Saito A ""Ondine's curse": side effect of acetazolamide?" Am J Med 86 (1989): 637