Details of Drug-Drug Interaction
| Drug General Information (ID: DDIULGPTM4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Octreotide | Drug Info | Dotatate | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Somatostatin/Somatostatin Analogs | Diagnostic Agents | |||||||
| Structure | |||||||||
| Mechanism of Octreotide-Dotatate Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph | |||||||||
 |
|||||||||
| Drug Name | Octreotide | Dotatate | |||||||
| Mechanism | Interfere with the uptake of Ga-68 dotatate into neuroendocrine tumors | Ga-68 dotatate | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetics | ||||||||
| Factor Description | Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
|
||||||||
| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | The manufacturer recommends imaging patients with gallium Ga-68 dotatate positron emission tomography (PET) just prior to dosing with long-acting somatostatin analogs. Short-acting formulations of somatostatin analogs can be used up to 24 hours before imaging with gallium Ga-68 dotatate. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Product Information. Netspot (dotatate). Advanced Accelerator Applications, New York, NY. | ||||||||||||||||||