Drug General Information (ID: DDIUEQAPLR)
Drug Name			Nalidixic acid		Drug Info		Sodium citrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Minerals And Electrolytes
Structure

Mechanism of Nalidixic acid-Sodium citrate Interaction (Severity Level: Moderate)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Nalidixic acid				Sodium citrate
Mechanism		Urine pH sensitive				Urine alkalinizer Increase the risk of crystalluria
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Nalidixic acid caused by Sodium citrate mediated altered urine pH

Recommended Action
Management		Concomitant use should generally be avoided. Patients receiving this combination should be monitored for signs of renal toxicity and crystalluria.

References
1	Multum Information Services, Inc. Expert Review Panel.
2	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.