Drug General Information (ID: DDIU2QCKV4)
  Drug Name Etoposide Drug Info Doxorubicin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antineoplastics Antineoplastics
  Structure

 Mechanism of Etoposide-Doxorubicin Interaction (Severity Level: Minor)
     Increased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Etoposide Doxorubicin
      Mechanism Increase the plasma clearance and urinary excretion of doxorubicin Doxorubicin
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Increased renal excretion of Doxorubicin caused by Etoposide 

References
1 Cummings J, Forrest GJ, Cunningham D, Gilchrist NL, Soukop M "Influence of polysorbate 80 (tween 80) and etoposide (VP-16-213 on the pharmacokinetics and urinary excretion of adriamycin and its metabolites in cancer patients." Cancer Chemother Pharmacol 17 (1987): 80-4. [PMID: 3698181]